Drimia indica: A Plant Used in Traditional Medicine and Its Potential for Clinical Uses

Aswal, Sonali; Kumar, Ankit; Semwal, Ruchi Badoni; Chauhan, Ashutosh; Kumar, Abhimanyu; Lehmann, Jörg; Semwal, Deepak Kumar

doi:10.3390/medicina55060255

Cited by 15 publications

(10 citation statements)

References 37 publications

(47 reference statements)

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“…Deepak et al (2003) have also mentioned that a similar plant is not consumed by either humans or animals due to toxicity. Hence, the oral administration of Drimia indica in any form may be a matter of serious concern, and further toxicity studies are warranted before its use as an oral drug (Aswal et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Toxic effects of Drimia maritima (Asparagaceae) ethanolic extracts on the mortality, development, sexual behaviour and oviposition behaviour of Drosophila melanogaster (Diptera: Drosophilidae)

Saadane

Habbachi

Boublata

et al. 2021

JABB

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Drimia maritima is a toxic Mediterranean plant and is considered a commercially important drug by its medicinal values and pharmacological properties. In this work, we seek to evaluate the direct and delayed effects of the ethanol extracts of this plant on vinegar fly (Drosophila melanogaster), an excellent laboratory model. The treatment was carried out by ingestion on second-stage larvae (L2) and then we evaluated the impact of this treatment on mortality, development, sexual behaviour, on female's oviposition choice, fecundity, and fertility of adults. The results showed that mortality rates can reach 100% after 15 days of treatment as we recorded an acceleration of the flies' development. After treatment, we observed incomplete nuptial courtship and a significant decrease in eggs laid number and larvae number of the first generation treated. This study indicates that D. maritima ethanolic extract has a neurotoxic property, our results confirmed the presence of toxic secondary metabolites in the extract studied.

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Section: Discussionmentioning

confidence: 99%

Toxic effects of Drimia maritima (Asparagaceae) ethanolic extracts on the mortality, development, sexual behaviour and oviposition behaviour of Drosophila melanogaster (Diptera: Drosophilidae)

Saadane

Habbachi

Boublata

et al. 2021

JABB

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“…In animals, intoxication may lead to muscular weakness, paralysis and even fatality caused by heart failure [ 96 ]. A number of studies have reported cardiac glycoside as a major toxic compound produced by Drimia species [ 19 , 99 , 100 , 101 ]. According to Kellerman et al [ 23 ], livestock ingest the flowers, leaves and sometimes the bulb of this plant as substitutes to green grass, and it was found to be toxic to livestock due to cardiac glycoside extracted from the plant’s bulb.…”

Section: Toxicity Of Drimia Sppmentioning

confidence: 99%

Bulbous Plants Drimia: “A Thin Line between Poisonous and Healing Compounds” with Biological Activities

et al. 2021

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Drimia (synonym Urginea) plants are bulbous plants belonging to the family Asparagaceae (formerly the family Hyacinthaceae) and are distinctive, powerful medicinal plants. Just some species are indigenous to South Africa and have been traditionally utilized for centuries to cure various diseases and/or ailments. They have been recognized among the most famous and used medicinal plants in South Africa. Traditionally, the plants are used for various illnesses such as dropsy, respiratory disease, bone and joint complications, skin disorders, epilepsy and cancer. A number of studies have reported biological properties such as antiviral, antibacterial, antioxidant and anti-inflammatory, immunomodulatory, and anticancer activities. Their bulbs are a popular treatment for colds, measles, pneumonia, coughs, fever and headaches. However, some plant species are regarded as one of the six most common poisonous plants in Southern Africa that are toxic to livestock and humans. Due to the therapeutic effects of the Drimia plant bulb, research has focused on the phytochemicals of Drimia species. The principal constituents isolated from this genus are cardiac glycosides. In addition, phenolic compounds, phytosterols and other phytochemical constituents were identified. This study constitutes a critical review of Drimia species’ bioactive compounds, toxicology, biological properties and phytochemistry, advocating it as an important source for effective therapeutic medicine. For this purpose, various scientific electronic databases such as ScienceDirect, Scopus, Google Scholar, PubMed and Web of Science were researched and reviewed to conduct this study. Despite well-studied biological investigations, there is limited research on the toxic properties and the toxic compounds of certain Drimia species. Searching from 2017 to 2021, Google Scholar search tools retrieved 462 publications; however, only 3 investigated the toxicity and safety aspects of Drimia. The aim was to identify the current scientific research gap on Drimia species, hence highlighting a thin line between poisonous and healing compounds, dotted across numerous publications, in this review paper.

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“…This genus (Family: Asparagaceae) is comprised of 99 accepted species. The members of this genus are mostly deciduous and rarely evergreen with an underground bulb [ 6 ]. Ethnomedicinal applications of numerous Drimia species have been widely reported, including the treatment of gout, bronchitis, asthma, and the use as expectorant and emetic agents [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn

Zhang

Zengin

Mahomoodally

et al. 2022

Plants

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Drimia maritima (L.) Stearn (squill), belonging to the Asparagaceae family, is acknowledged as a medicinally valuable species from the Drimia genera. In this study, water, methanol, and ethyl acetate extracts of D. maritima aerial parts and bulbs were investigated for their polyphenols profile and evaluated for their antioxidant and enzyme inhibition properties. Phenolics were profiled through an untargeted metabolomics approach using an ultra-high pressure liquid chromatograph coupled to quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS). This analysis revealed an enrichment of low molecular weight phenolics and flavonoids in the aerial parts of D. maritima, while lignans mainly characterized bulb extracts. Antioxidant capacity was investigated by different assays, including phosphomolybdenum assays, radical scavenging (DPPH: 2,2-diphenyl-1-picrylhydrazyl; ABTS: 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), as well as reducing ability (CUPRAC: cupric reducing antioxidant capacity; FRAP: ferric reducing antioxidant power), and metal chelating. In radical scavenging and reducing power assays, the water extract of aerial parts exhibited the strongest ability (DPPH: 36.99 mg trolox equivalent (TE)/g; ABTS: 85.96 mg TE/g; CUPRAC: 87.37 mg TE/g; FRAP: 55.43 mg TE/g). In general, the ethyl acetate extracts from aerial parts and bulbs provided the weakest antioxidant capacity. Concerning enzyme inhibitory activities, the water extracts of the bulb were poorly active, while the ethyl acetate extracts from both plant portions displayed the best α-amylase inhibitory abilities. The best acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) abilities were recorded by ethyl acetate extract of aerial parts (2.36 mg galantamine equivalent (GALAE)/g) and bulbs (5.10 mg GALAE/g), respectively. Overall, these results support the medicinal aptitude of D. maritima and its possible use as a natural source of antioxidants and enzyme inhibitors with functional potential.

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Drimia indica: A Plant Used in Traditional Medicine and Its Potential for Clinical Uses

Cited by 15 publications

References 37 publications

Toxic effects of Drimia maritima (Asparagaceae) ethanolic extracts on the mortality, development, sexual behaviour and oviposition behaviour of Drosophila melanogaster (Diptera: Drosophilidae)

Toxic effects of Drimia maritima (Asparagaceae) ethanolic extracts on the mortality, development, sexual behaviour and oviposition behaviour of Drosophila melanogaster (Diptera: Drosophilidae)

Bulbous Plants Drimia: “A Thin Line between Poisonous and Healing Compounds” with Biological Activities

Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn

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