Novel findings of Langerhans cells and interleukin-17 expression in relation to the acrosyringium and pustule in palmoplantar pustulosis

Abstract

Our novel findings indicate that the inflammation in PPP is initiated by the 'stand-by' innate immune system at the acrosyringium.

A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx

“…In our study, the mRNA expression of both IL‐8 and IL‐17A was significantly higher in PPP than in pompholyx, whereas the levels of IL‐22 mRNA did not significantly differ between the two diseases. Hagforsen E et al . previously reported that inflammatory cells located in epidermis and/or in pustules in PPP lesion expressed IL‐17, a cytokine believed to upregulate IL‐8 expression in keratinocytes .…”

Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus

“…However, it has been shown that IL‐17 is not only expressed in inflammatory cells, but also in epidermal sweat ducts in palmar skin in patients with palmoplantar psoriasis, in gluteal skin from patients with psoriasis, and in skin from healthy controls. In addition, IL‐17‐like immunoreactivity has also been found in the stratum granulosum in healthy controls 53 . Therefore, the origin of IL‐17 staining in the epidermis should be a subject for future work to elucidate the pathogenesis of LE, as we focused only on its expression in inflammatory cells.…”

Management of palmoplantar pustulosis: do we need to change?

“…In addition, the pattern of antimicrobial peptide expression was different from that seen in plaque psoriasis. New data describe the involvement of innate immune responses through Langerhans cells and the generation of interleukin (IL)‐17 in relation to the acrosyringium and pustule formation 18 …”