A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx

Kim, D.Y.; Kim, J.Y.; Kim, T.G.; Kwon, Ji Eun; Sohn, Hong Gyoo; Park, J.; Lim, Beom Jin; Oh, Sang‐Hwan

doi:10.1111/jdv.12203

Cited by 10 publications

(11 citation statements)

References 34 publications

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“…This confirms our previous RT-PCR findings in patients with PPP/PPPP which showed an increase in IL-17 gene expression without an increase in IL-23 [ 5 ]. Increase in IL-17 in PPP/PPPP has also been reported by others [ 14 – 16 ]. In addition, there was no significant difference in CXCL9 and OAS2 (not shown) which are both induced by interferon-gamma.…”

Section: Discussionsupporting

confidence: 84%

Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris

Bissonnette¹,

Suárez‐Fariñas²,

Li³

et al. 2016

PLoS ONE

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IntroductionThere is a controversy surrounding the existence of palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) as separate clinical entities or as variants of the same clinical entity. We used gene expression microarray to compare gene expression in PPP and PPPP.Methodology/Principal findingsSkin biopsies from subjects with PPP (3), PPPP (6), psoriasis vulgaris (10) and acral skin from normal subjects (7) were analyzed using gene expression microarray. Principal component analysis showed that PPP and PPPP were different from psoriasis vulgaris and normal acral skin. However gene expression of PPP and PPPP clustered together and could not be used to differentiate PPP from PPPP. Gene-wise comparison between PPP and PPPP found no gene to be differentially expressed at a false discovery rate lower than 0.05. Surprisingly we found a higher expression of several genes involved in neural pathways (e.g. GPRIN and ADAM23) in PPP/PPPP as compared to psoriasis vulgaris and normal acral skin. Immunohistochemistry confirmed those findings and showed a keratinocyte localization for those proteins.Conclusion significancePPP and PPPP could not be differentiated using gene expression microarray suggesting that they are not distinct clinical entities. Increased expression of GPRIN1, and ADAM23 in keratinocytes suggests that these proteins could be new therapeutic targets for PPP/PPPP.

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Section: Discussionsupporting

confidence: 84%

Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris

Bissonnette¹,

Suárez‐Fariñas²,

Li³

et al. 2016

PLoS ONE

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“…The principal differential diagnosis, both clinically and histopathologically, is pompholyx, which has two phases: vesicle and pustule [50]. A few studies have been published on histopathological differences between PPP and pompholyx [50][51][52][53]. It has also been suggested that the acrosyringium (i.e., intraepidermal duct of the eccrine glands) is the primary site of vesicle/pustule formation in PPP, in comparison with pompholyx, where the acrosyringium is damaged and rupture is secondary to inflammation [51].…”

Section: Histologymentioning

confidence: 99%

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

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Palmoplantar pustulosis (PPP) is a chronic, recurrent skin disease belonging to the spectrum of psoriasis. It is characterized by an eruption of sterile pustules on the palms and soles. Recent studies in PPP have focused on genetic differences between pustular phenotypes and the role of the innate immunological system and the microbiome in the etiopathogenesis of the disease. Mutations in IL36RN (a major predisposing factor for generalized pustular psoriasis) were found in selected patients with PPP and were associated with earlier disease onset. Studies have shown that the interleukin (IL)-17 and IL-36 pathways might be involved in the pathogenesis of PPP. A microbiome has been demonstrated in the vesicopustules of PPP, and an abundance of Staphylococcus appears to be increased by smoking. Improved understanding of the underlying etiopathogenesis of PPP has led to advances in treatment options, and targeted therapies for PPP have been evaluated or are under evaluation against more than 12 molecules in ongoing clinical trials.

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“… 98 The inflammation is further driven by the proliferation of inflammatory cytokines such as IL-8 and IL-17. 94 IL-17A is highly expressed in the palms and soles of patients with PPP in comparison to healthy subjects, 89 while interestingly, IL-12 and IL-23 are not significantly expressed in these areas of patients with PPP. These findings imply a more central role for IL-17A in the inflammatory process for PPP compared to IL-12/IL-23, a difference which could have important implications for treatment.…”

Section: Localized Pustular Psoriasismentioning

confidence: 90%

“…Sensitivities to metals have also been cited as precipitating factors in PPP. 90 , 94 The most common metal sensitivity described is to nickel and occurs in 3% of patients with PPP. 83 Other metal allergies described include chrome and cobalt.…”

Section: Localized Pustular Psoriasismentioning

confidence: 99%

Pustular psoriasis: pathophysiology and current treatment perspectives

Benjegerdes¹,

Hyde²,

Kivelevitch³

et al. 2016

PTT

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Psoriasis vulgaris is a chronic inflammatory disease that classically affects skin and joints and is associated with numerous comorbidities. There are several clinical subtypes of psoriasis including the uncommon pustular variants, which are subdivided into generalized and localized forms. Generalized forms of pustular psoriasis include acute generalized pustular psoriasis, pustular psoriasis of pregnancy, and infantile and juvenile pustular psoriasis. Localized forms include acrodermatitis continua of Hallopeau and palmoplantar pustular psoriasis. These subtypes vary in their presentations, but all have similar histopathologic characteristics. The immunopathogenesis of each entity remains to be fully elucidated and some debate exists as to whether these inflammatory pustular dermatoses should be classified as entities distinct from psoriasis vulgaris. Due to the rarity of these conditions and the questionable link to the common, plaque-type psoriasis, numerous therapies have shown variable results and most entities remain difficult to treat. With increasing knowledge of the pathogenesis of these variants of pustular psoriasis, the development and use of biologic and other immunomodulatory therapies holds promise for the future of successfully treating pustular variants of psoriasis.

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A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx

Cited by 10 publications

References 34 publications

Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris

Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

Pustular psoriasis: pathophysiology and current treatment perspectives

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