Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

“…Additionally, the study of drugs with monolayers of liquids is interesting, since recently, lipid miscellas encapsulating different drugs have been proposed as drug delivery systems. In this context, recent works have proposed Pluronic F127 nanomicelles to encapsulate and control the release of the antineoplastic drug carfilzomib [ 16 ], nanostructures to deliver therapeutic drugs for pancreatic cancer treatment via the EPR-mediated effect [ 17 ] and a pH-sensitive vesicular system of non-ionic surfactants and cholesterol loaded with deferasirox, an iron chelator used for the treatment of transfusional iron [ 18 ].…”

Self-Assembled Immunostimulatory Tetrahedral Framework Nucleic Acid Vehicles for Tumor Chemo-immunotherapy

“…This phenomenon is known as the enhanced permeability and retention (EPR) effect. 6,7 Although the development of drug-loaded nanoparticles has been evolving for decades, they have not yet been widely approved for clinical use due to biosafety concerns. Remarkably, as a kind of framework nucleic acid synthesized from oligonucleotides by Watson−Crick pairing, tFNA, exhibited great potential in drug delivery for its outstanding intrinsic biocompatibility 8 superior membrane permeability.…”

“…Interestingly, the lack of supporting tissues for vasculature encourages the formation of leaky vessels and pores, which facilitate nanoparticles permeation and retention in tumor tissue. This phenomenon is known as the enhanced permeability and retention (EPR) effect. , Although the development of drug-loaded nanoparticles has been evolving for decades, they have not yet been widely approved for clinical use due to biosafety concerns. Remarkably, as a kind of framework nucleic acid synthesized from oligonucleotides by Watson–Crick pairing, tFNA, exhibited great potential in drug delivery for its outstanding intrinsic biocompatibility and superior membrane permeability. − Its extensive biological application in drug or gene-targeted delivery and diagnosis has , has been widely reported. , As a result, the application of tFNA in passive tumor-targeted delivery via EPR was promising because of its special framework morphology and desirable size. − …”

Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs

“…Furthermore, at the molecular level, researchers are examining the evolution and characteristics of HPV infections to gain a better knowledge of the true burden of HPV-related illnesses and their repercussions around the world ( 26 ). This would enable the discovery of novel treatment technologies for the innovation of next-generation anti-viral vaccines, to overcome the drawbacks of the present preventive regimen, including high prices, limited antiviral protective spectrum, and vaccination management ( 27 – 29 ).…”

“…Furthermore, at the molecular level, researchers are examining the evolution and characteristics of HPV infections to gain a better knowledge of the true burden of HPV-related illnesses and their repercussions around the world (26). This would enable the discovery of novel treatment technologies for the innovation of next-generation anti-viral vaccines, to overcome the drawbacks of the present preventive regimen, including high prices, limited antiviral protective spectrum, and vaccination management (27)(28)(29). In the current review, we have drawn a comparison between the currently available vaccines, Cervarix and Gardasil, emphasizing the clinical importance of vaccines that are being produced in recent times and shed light on their ongoing clinical trials.…”