Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

Betancourt, Sara N. Moya; Cámara, Candelaria Inés; Riva, Julieta Soledad

doi:10.3390/pharmaceutics15020311

Cited by 5 publications

(1 citation statement)

References 34 publications

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“…MIPs have found wide applications for various analytes such as viruses, bacteria, emerging pollutants, pharmaceutical drugs, and pesticides [ 15 , 16 , 17 ]. MIPs are largely used for the preparation of samples and the extraction of target analytes from complex matrices when combined with magnetic nanoparticles (MNPs) [ 18 , 19 , 20 ]. This combination offers several advantages.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Molecularly Imprinted Chitosan Combined with a Paper-Based Analytical Device for the Smartphone Discrimination of Tryptophan Enantiomers

Karrat,

García-Guzmán,

Palacios-Santander

et al. 2023

Biosensors

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The separation of enantiomers plays a critical role in pharmaceutical development, ensuring therapeutic efficacy, safety, and patent protection. It enables the production of enantiopure drugs and enhances our understanding of the properties of chiral compounds. In this study, a straightforward and effective chiral detection strategy was developed for distinguishing between tryptophan (TRP) enantiomers. The approach involved the preparation of a magnetic molecularly imprinted chitosan (MMIC) for preparation of the sample, which was combined with a nitrocellulose membrane (a paper-based analytical device, PAD) integrated with D-TRP covalently grafted with polymethacrylic acid (PAD-PMA_D-TRP). Discriminating between the TRP enantiomers was achieved using AuNPs as a colorimetric probe. Indeed, the presence of D-TRP rapidly induced the aggregation of AuNPs due to its strong affinity to PAD-PMA_D-TRP, resulting in a noticeable change in the color of the AuNPs from red to purple. On the other hand, L-TRP did not induce any color changes. The chiral analysis could be easily performed with the naked eye and/or a smartphone. The developed method exhibited a detection limit of 3.3 µM, and it was successfully applied to detect TRP in serum samples, demonstrating good recovery rates. The proposed procedure is characterized by its simplicity, cost-effectiveness, rapidity, and ease of operation.

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