Novel electrochemical synthesis of copper oxide nanoparticles decorated graphene-β-cyclodextrin composite for trace-level detection of antibiotic drug metronidazole

Abstract

Over the past decades, the synthesis of inorganic and organic nanocomposites has received much attention in the range of fields including electroanalysis of organic chemicals. In this regard, we have prepared copper oxide nanoparticle (CuO NPs) decorated graphene/β-cyclodextrin (GR-β-CD) composites using a simple electrochemical methodology, where the CuO NPs are electrodeposited on GR-β-CD composite modified electrodes. A stable GR-β-CD composite was prepared by sonication of GR in β-CD aqueous solution. As-prepared GR-β-CD/CuO NPs composites were characterized by the high-resolution scanning electron microscopy, X-ray diffraction, and Raman spectroscopy. Cyclic voltammetry results reveal that the GR-β-CD/CuO NPs composite modified electrode exhibits an excellent catalytic activity and lower reduction potential towards the electrochemical detection of metronidazole (MTZ) over other modified electrodes including GR, GR-β-CD, and CuO NPs. Under optimized conditions, amperometry was used for the determination of MTZ using GR-β-CD/CuO NPs composite modified electrodes. The response of MTZ using the composite electrodes was linear over the range from 0.002 to 210.0 µM. This sensor showed the lowest limit of detection of 0.6 nM and was much lower than the previously reported MTZ sensors. In addition, the sensor is highly sensitive, selective and durable in the presence of a range of potentially interfering electroactive compounds.

Enhancing the chloramphenicol sensing performance of Cu–MoS2 nanocomposite-based electrochemical nanosensors: roles of phase composition and copper loading amount

“…Copper, a low-cost transition metal, and its oxides have received signicant attention in the scientic community because of their interesting electronic and surface structures, excellent redox, high catalytic activity, as well as antifungal and antifouling properties. [12][13][14][15] With such unique properties, copper-based NMs have been widely used in sensors, 16 photocatalysis, 17 and antimicrobial applications. 15 Copper nanoparticles (Cu-NPs) were developed in electrochemical sensors to take advantage of their inherent merits, such as conductivity, excellent redox, and cost-effectiveness in comparison with other noble metal NPs.…”

“… 16 Cupric oxide nanoparticles (CuO-NPs), as a semiconductor, were used to improve the electrocatalytic activity of graphene-modified electrodes in the electrochemical sensor for the determination of metronidazole. 13 Cuprous oxide nanoparticles (Cu 2 O-NPs), as a typical p-type semiconductor, which integrated with rGO for electrochemical detection of dimetridazole, also showed significant improvement in the electrocatalytic activity towards dimetridazole. 18 The current reviews of NMs-based electrochemical sensors for antibiotics have indicated that hybrid structures, especially the 2D NMs-based hybrid structures, are strong candidates in the development of advanced electrochemical sensors.…”

Chemistry, Structures, and Advanced Applications of Nanocomposites from Biorenewable Resources

“…In recent years, copper oxide nanoparticles doped graphene(GR)-β-CD composites have been reported for the detection of metronidazole as an antibiotic drug (Figure 37). 272 The fabricated electrode displayed a linear electrochemical response between 0.002 and 210.0 µM concentration range and 0.6 nM metronidazole detection limit. The electrochemical results…”

Low-Dimension Nanomaterial-Based Sensing Matrices for Antibiotics Detection: A Mini Review

“…The types of nanomaterials adopted for the determination of antibiotics are as follows. Among them, 0D materials include nanoclusters (Zang et al, 2013 ), nanoparticles (Wu et al, 2018 ), and quantum dots (QDs) (Malik et al, 2019 ); the 1D materials include nanowires (Shad et al, 2019 ), nanotubes (Xiao et al, 2007 ), and nanorods (Roushani and Ghanbari, 2018 ); the 2D materials include nanoflakes (Zeng et al, 2018 ) and nanofilms (Velusamy et al, 2018 ).…”