Novel electrochemical sensing platform for ultrasensitive detection of cardiac troponin I based on aptamer-MoS2 nanoconjugates

Qiao, Xiujuan; Li, Kunxia; Xu, Jinqiong; Ni, Cheng; Sheng, Qinglin; Cao, Wei; Yue, Tianli; Zheng, Jianbin

doi:10.1016/j.bios.2018.05.003

Cited by 78 publications

(33 citation statements)

References 37 publications

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“…Different electrochemical techniques have been used in sensing cardiac biomarkers. The most commonly used techniques are amperometry [11,14], square wave voltammetry (SWV) [15], differential pulse voltammetry (DPV) [5,16], stripping voltammetry [17], and electrochemical impedance spectroscopy (EIS) [1,18].…”

Section: Electrochemical Techniques For Sensing Cardiac Biomarkersmentioning

confidence: 99%

“…The amperometric biosensors are versatile tools for rapid and user-friendly screening detection of biomarkers due to low detection limits, good selectivity and high specificity in analysing complex samples using simple instruments and procedures [19]. Based on those features, biosensors of various cardiac biomarkers such as thrombin [11,20], troponin-I [11,15], heart-type fatty-acid-binding protein [14], etc., were developed.…”

Section: Electrochemical Techniques For Sensing Cardiac Biomarkersmentioning

confidence: 99%

“…It is one of the most sensitive analytical methods used to detect trace analytes [23]. These characteristics lead to the development of electrochemical biosensors for different cardiac biomarkers such as myoglobin [10], troponin I [15], troponin T [2], thrombin [24], Creatine kinase-MB [25], etc.…”

Section: Electrochemical Techniques For Sensing Cardiac Biomarkersmentioning

confidence: 99%

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Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

Nsabimana

Yuan

et al. 2018

Electroanalysis

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The development of the methods for early and accurate diagnosis of acute myocardial infarction are needed to facilitate immediate treatment of patients. One of the ways to achieve that is the detection of cardiac biomarkers for myocardial infarction, such as thrombin, cardiac troponins (I and T), myoglobin, etc. Nanotechnology has played an important role in the development of sensitive and efficient electrochemical sensors for cardiac biomarkers. In this review, we discuss recent progress on nanomaterial‐based electrochemical sensing of various cardiac biomarkers for acute myocardial infarction.

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Section: Electrochemical Techniques For Sensing Cardiac Biomarkersmentioning

confidence: 99%

Section: Electrochemical Techniques For Sensing Cardiac Biomarkersmentioning

confidence: 99%

Section: Electrochemical Techniques For Sensing Cardiac Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

Nsabimana

Yuan

et al. 2018

Electroanalysis

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“…MoS 2 is a typical dichalcogenide, which attracts wide interests in numerous fields, such as hydrogen catalysis and storage, capacitors, and electrochemical device [36] , [37] . However, because the conductivity of MoS 2 is still lower than that of carbon-based materials, little attention has been paid to the application of MoS 2 as an electrode material for sensors [38] .…”

Section: Introductionmentioning

confidence: 99%

An advanced molecularly imprinted electrochemical sensor for the highly sensitive and selective detection and determination of Human IgG

Liang

Hou

Tang

et al. 2021

Bioelectrochemistry

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“…Aptamers can be used as an active ligand and are designed only for a specific target by the use of the systematic evolution of ligands by the exponential enrichment (SELEX) technique. [2] They are great rivals for antibodies, especially about binding affinities, thermal stability, versatility, and ease of modification. [3] Aptasensors, with aptamer as the recognizing element, is used to quantify molecules based on the specificity and the selectivity in an attachment to the aptamer.…”

Section: Introductionmentioning

confidence: 99%

Predicting the Cardiac Troponin I (cTnl) Aptamer/Methylene Blue Configuration Using Computational Modeling Studies: A Screening Search Method for Constructing Aptasensors

et al. 2020

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Acute Myocardial Infarction (AMI) is the most common cause of mortality, and cardiac troponin I (cTnI) is the gold standard for AMI diagnosis. Some aptamers have been reported to detect cTnI, but there is rarely any structural information on their binding with cTnI. There are many studies involving electrochemical aptasensors with methylene blue (MB) as a redox indicator that does not provide any significant new information. Our study, however, involves the computational modeling of the complexes of a documented 40‐mer ssDNA‐cTnI aptamer with its target and MB. Here, MB was used as a model system to investigate the rather complex interaction modes between small redox molecules and a cTnI‐aptamer. Understanding these modes is an important facet in designing electrochemical aptasensors to ascertain the effectiveness of a redox indicator. In our study, docking and molecular dynamics (MD) were used to provide information on the stability, fluctuations, and interaction analysis of the complexes. Based on computational evaluations, we understand how the structure of the cTnI‐aptamer steers the MB releasing after inducing cTnI. In order to evaluate the sensing performance of the cTnI‐aptamer in the presence of MB experimentally, after covalent immobilization of the 5‐amino terminated cTnI‐aptamer at a pre‐functionalized carboxylated multi‐walled carbon nanotube (COOH‐MWCNT) glassy carbon electrode, some techniques including spectroscopy and voltammetry were employed.

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Novel electrochemical sensing platform for ultrasensitive detection of cardiac troponin I based on aptamer-MoS2 nanoconjugates

Cited by 78 publications

References 37 publications

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

Nanomaterials‐based Electrochemical Sensing of Cardiac Biomarkers for Acute Myocardial Infarction: Recent Progress

An advanced molecularly imprinted electrochemical sensor for the highly sensitive and selective detection and determination of Human IgG

Predicting the Cardiac Troponin I (cTnl) Aptamer/Methylene Blue Configuration Using Computational Modeling Studies: A Screening Search Method for Constructing Aptasensors

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