Novel effects of Rosa damascena extract on patients with neurocognitive disorder and depression: A clinical trial study

Abstract

Background:Dementia as a major cognitive neurological disorder is defined as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patient's independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the efficacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia.Methods:This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 2015–2016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil and R. damascena capsules, and in control group, placebo capsule instead of R. damascena added on donepezil. Four test was filled three times at the study initiation, after month one and also after month three: Mini–Mental State Examination (MMSE) and Addenbrooke's Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered, and checklist of memory and behavioral disorders were filled.Results:The results showed add-on donepezil and R. damascena versus placebo improved cognitive impairment based on MMSE with P = 0.002, ACE-R with total P = 0.001, depression (P = 0.012), behavioral disorders (P < 0.001), and daily activity (P < 0.001).Conclusions:The R. damascena extract affected cognitive impairment of dementia patients significantly and also have significant effects on improving depression and behavioral problems.

The effect of the rose essential oil aroma on university students’ learning and short-term memory: A randomized controlled trial

“…Rosa damascena extract has been reported to significantly reduce dementia patients' cognitive impairment [8].…”

“…Aromatherapy is usually administered through inhalation because essential oils vaporize easily [1]. Many studies have shown the positive effects of pure essential oils on attention span [2], recall speed and quality [3], memory performance [4,5], short-term memory [6], image memory [7] in healthy individuals and on memory and moods in the cognitive disorders of dementia [8]. These effects occur due to the connections of the tractus olfactorius to the limbic system and the hypothalamus [9,10,11].…”

A mini review of neuropharmacological effects of Rosa damascena Herrm.

“…It has been suggested that these effects may be due to the inhibition of serotonine reuptake. 32 The Anti-anxiety and anti-depressive effects of R. damascena were shown in Table 1.…”

Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Furthermore, oral administration of Jollab (an extract of RDM) significantly reduced depression amongst patients suffering from functional dyspepsia (Pasalar et al, 2015). Other RCTs also reported the effects of RDM on anxiety or depression induced by labor (Hamdamian et al, 2018;Kheirkhah, Setayesh Valipour, Nisani, & Haghani, 2014), HD (Barati, Nasiri, Akbari, & Sharifzadeh, 2016), burn dressing (Daneshpajooh, Najafi Ghezeljeh, & Haghani, 2019;Sadeghi, Azizi, Asgari, & Mohammadi, 2020), surgery (Amini & Alizadeh, 2018;Bastani, Samady Kia, & Haghani, 2020;Najafi, Sajjadi, Nasirzadeh, & Jeddi, 2020;Noorian, Madadkar Dehkordi, Doosti Irani, & Azari, 2020;Seyyed-Rasooli, Amiri, Zamanzadeh, Peron, & Aghakeshizadeh, 2014), menstruation (Jamilian, Jamilian, & Mirzaie, 2013), job (Gholami, Teymouri, Farsi, & Rajai, 2019), hospitalization (Hashemi Siyavoshani, Fallahi Arezodar, Pishgooei, & Jadid Milani, 2020;Jodaki et al, 2021), and dementia (Esfandiary et al, 2018).…”