Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: An overview

Thakur, Sourav; Riyaz, Bushra; Patil, Abhinandan; Kaur, Amanjot; Kapoor, Bhupinder; Mishra, Vijay

doi:10.1016/j.biopha.2018.07.027

Cited by 110 publications

(61 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ketoprofen, naproxen sodium or ibuprofen, are among the most frequently used for suppression of PGE 2 and COX-2. In spite of the inflammation relief effect, most of the NSAIDs inhibit also COX-1 enzyme and COX-1-derived prostaglandins, causing gastrointestinal and cardiovascular complications (Thakur et al, 2018). Thus, safe and effective alternatives for treatment of inflammation processes using plant-derived molecules are being continuously sought (Koeberle and Werz, 2018).…”

Section: Discussionmentioning

confidence: 99%

Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils

Amirova

Dimitrova

Marchev

et al. 2019

Food and Chemical Toxicology

View full text Add to dashboard Cite

Clinopodium vulgare L. (wild basil) has a wide range of ethnopharmacological applications and accumulates a broad spectrum of phenolic compounds, recognized for their anti-inflammatory and anticancer properties. The triggered cyclooxygenase-2 (COX-2) expression is creating an immunosuppressive microenvironment in the inflamed tissue and considered to be the main cause of failure of even new anticancer-/immune-therapies. Nowadays, selective and novel plant-derived COX-2 inhibitors with safe profile are subject of profound research interest. This study aimed to analyze the metabolic profile of C. vulgare and search for phenolic molecules with potential biological properties. By application of 1 H and 2D-NMR (Nuclear Magnetic Resonance) profiling, caffeic, chlorogenic acids and catechin were identified along with a bunch of primary and secondary metabolites. Further, the biological effect of C. vulgare extract (CVE) and its constituents on zymosan-induced COX-2 expression and apoptosis of murine neutrophils have been studied. The CVE, caffeic and chlorogenic acids inhibited zymosan-induced COX-2 expression in bone marrow neutrophils, in vitro and in vivo activated. The obtained data indicate that CVE may have a good potential to manipulate neutrophil functions, however, its action may depend on the cellular state, the inflammatory milieu and the relative content of caffeic and chlorogenic acid in the extract.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils

Amirova

Dimitrova

Marchev

et al. 2019

Food and Chemical Toxicology

View full text Add to dashboard Cite

show abstract

“…To circumvent disadvantages of anti-inflammatory therapies based on traditional formulations, different advanced drug delivery systems have been investigated over the past decades. In this aspect, dendrimers, lipid nanoparticles, polymeric nanoparticles, micelles, nanocapsules, nanoemulsions, nanofibers, microparticles, hydrogels, and multi-compartmental delivery systems were examined for delivery of either molecular therapies or therapeutic cells for the treatment of inflammatory diseases [ [33] , [34] , [35] , [36] , [37] , [38] ]. In addition to the totally synthesized vehicles across multiple length scales, some biomimetic particles such as exosomes, cell membrane-based nanovehicles, and cellular carriers have been developed for delivery of anti-inflammatory agents [ [39] , [40] , [41] , [42] ].…”

Section: Introductionmentioning

confidence: 99%

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Ding

et al. 2020

Journal of Controlled Release

107

View full text Add to dashboard Cite

Inflammation is intimately related to the pathogenesis of numerous acute and chronic diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and neurodegenerative diseases. Therefore anti-inflammatory therapy is a very promising strategy for the prevention and treatment of these inflammatory diseases. To overcome the shortcomings of existing anti-inflammatory agents and their traditional formulations, such as nonspecific tissue distribution and uncontrolled drug release, bioresponsive drug delivery systems have received much attention in recent years. In this review, we first provide a brief introduction of the pathogenesis of inflammation, with an emphasis on representative inflammatory cells and mediators in inflammatory microenvironments that serve as pathological fundamentals for rational design of bioresponsive carriers. Then we discuss different materials and delivery systems responsive to inflammation-associated biochemical signals, such as pH, reactive oxygen species, and specific enzymes. Also, applications of various bioresponsive drug delivery systems in the treatment of typical acute and chronic inflammatory diseases are described. Finally, crucial challenges in the future development and clinical translation of bioresponsive anti-inflammatory drug delivery systems are highlighted.

show abstract

“…The non-steroidal anti-inflammatory drug (NSAID) aspirin ( 9 ) and the derivative, salicylic acid ( 8 ) were also chosen as co-formulants. Compounds 8 and 9 were selected because despite effective and widespread use, the associated gastrointestinal and cardiovascular side effects of these drugs have led to the development of topical formulations and drug incorporation into carriers to reduce toxicity [ 25 , 26 ]. To investigate the potential for SSAs to act in this capacity, these drugs have been incorporated with SSAs 2 and 3 (co-formulations g – j ).…”

Section: Introductionmentioning

confidence: 99%

Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles

et al. 2020

View full text Add to dashboard Cite

Herein, we present a series of supramolecular self-associating amphiphilic (SSA) salts and establish the potential for these molecular constructs to act as next-generation solution-state molecular delivery vehicles. We characterise the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, whilst high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-d6/0.5% H2O). However, extended self-associated aggregates are observed to form under aqueous conditions (H2O/5.0% EtOH) in both the absence and presence of these competitive guest species. Finally, through the completion of these studies, we present a framework to support others in the characterisation of such systems.

show abstract

Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: An overview

Cited by 110 publications

References 123 publications

Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils

Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles

Contact Info

Product

Resources

About