Novel drug delivery approaches for the management of hair loss

Alsalhi, Waleed; Alalola, Ammar; Gwillim, Eran C.; Tosti, Antonella

doi:10.1080/17425247.2020.1723543

Cited by 40 publications

(41 citation statements)

References 50 publications

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“…The symptoms of hair loss and thinning start as bitemporal recession at the frontal hairline, followed by diffuse thinning over the vertex of the scalp [ 2 ]. The standard treatment for this condition is either hair follicle transplantation or the stimulation of these follicles with topical or oral medication [ 3 , 4 , 5 , 6 ]. However, these methods are not proven to treat hair loss and can have problematic side effects and high costs [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.

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Section: Introductionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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“…However, the US Food and Drug Administration (FDA) has only approved the topical use of minoxidil and the oral use of finasteride as effective therapies for the treatment of androgenetic alopecia 29 . Previous work investigated RF as an approach for increasing drug penetration into the scalp 30 …”

Section: Resultsmentioning

confidence: 99%

Evaluation of the evidence level for the use of radiofrequency in aesthetic treatments: A systematic review and meta‐analysis

Paggiaro

Pinheiro

Soares

et al. 2021

J of Cosmetic Dermatology

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Background Radiofrequency (RF) is a non‐invasive or minimally invasive procedure with a low risk of complications. It has been employed for several aesthetic purposes. Aim This study aimed to conduct a systematic literature review on the use of RF for aesthetic applications and assess the level of accumulated evidence for each condition. Methods Using the MEDLINE/PubMed and EMBASE databases, we searched for articles published from 2009 to 2019 describing the use of RF treatment for aesthetic purposes. Results Our search approach identified 25 randomized clinical trials investigating the efficacy of RF in the following clinical situations: body contour improvement, facial rejuvenation, acne scar treatment, alopecia, and rosacea. There were problems with the quality of the studies, especially regarding selection, performance, and detection bias. Conclusion Our study revealed that RF treatment is potentially promising in all of the evaluated clinical situations; however, we were not able to identify a level of evidence that justifies its use over other therapeutic options currently available on the market.

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“…There is still an unmet need for therapies capable to provide satisfying and long-term results. Recently, Alsalhi and colleagues have been published an interesting review related to the novel drug delivery approaches for the management of hair loss, highlighting the use of the mesotherapy, a minimally invasive and relatively painless procedure [ 23 ]. This technique includes injections of medications and/or vitamin mixture directly into the skin (dermis or subcutaneous layer) for the treatment of lipolysis, skin rejuvenation, pigmentation, and as already mentioned, hair loss.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

Zerbinati

Sommatis

Maccario

et al. 2021

BioMed Research International

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Dermal papilla cells (DPCs) are a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth. The protection from reactive oxygen species (ROS) and the promotion of angiogenesis are considered two of the basal mechanisms to preserve the growth of the hair follicle. In this study, a noncrosslinked hyaluronic acid (HA) filler (HYDRO DELUXE BIO, Matex Lab S.p.A.) containing several amino acids was tested with in vitro assays on human follicle dermal papilla cells (HFDPCs). The experiments were carried out to investigate the possible protection against oxidative stress and the ability to increase the vascular endothelial growth factor (VEGF) release. The results demonstrated the restoration of cell viability against UVB-induced cytotoxicity and an increase in the VEGF secretion. These data demonstrate the capability of the product to modulate human dermal papilla cells, suggesting a future use in mesotherapy, a minimally invasive local intradermal therapy (LIT), after further clinical investigations.

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Novel drug delivery approaches for the management of hair loss

Cited by 40 publications

References 50 publications

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Evaluation of the evidence level for the use of radiofrequency in aesthetic treatments: A systematic review and meta‐analysis

In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

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