Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids

Lee, Sang‐Hee; Mendoza, Theresa R; Burner, Danielle; Muldong, Michelle; Wu, Christina; Arreola-Villanueva, Catalina; Zuniga, Abril; Greenburg, Olga; Zhu, William; Murtadha, Jamillah; Koutouan, Evodie; Pineda, Naomi; Pham, Hao; Kang, Sung-Gu; Kim, Hyun Tae; Pineda, Gabriel; Lennon, Kathleen M.; Cacalano, Nicholas A.; Kane, Christopher J.; Kulidjian, Anna; Gaasterland, Terry; Jamieson, Christina

doi:10.3390/ijms23063203

Cited by 8 publications

(3 citation statements)

References 94 publications

(160 reference statements)

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“…Cellular plasticity and clonality can not only be influenced by the microenvironment, but also by specific therapies [241]. To investigate resistance mechanisms of androgen pathway directed therapy, Lee et al generated tumoroids from patient-derived xenograft models of bone metastatic PCa.…”

Section: Cellular Plasticity and Metastasismentioning

confidence: 99%

“…To investigate resistance mechanisms of androgen pathway directed therapy, Lee et al generated tumoroids from patient-derived xenograft models of bone metastatic PCa. Androgen ablation led to the development of reversibly dormant basal-luminal-like hybrid cells, highlighting how some cancer therapies might even support the progression of the disease, thus suggesting that treatment regimens might have to be reviewed [241]. Apart from tumor case study showed that drug testing using xenografted PDTs is feasible in real time and can lead to beneficial results for patients [108].…”

Section: Cellular Plasticity and Metastasismentioning

confidence: 99%

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A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine

Kalla,

Pfneissl,

Mair

et al. 2024

Cell Oncol.

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Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy efficacy and outcome for cancer patients, more representative and patient-specific preclinical models are needed. Organoids and tumoroids are 3D cell culture models that typically retain the genetic and epigenetic characteristics, as well as the morphology, of their tissue of origin. Thus, they can be used to understand the underlying mechanisms of cancer initiation, progression, and metastasis in a more physiological setting. Additionally, co-culture methods of tumoroids and cancer-associated cells can help to understand the interplay between a tumor and its tumor microenvironment. In recent years, tumoroids have already helped to refine treatments and to identify new targets for cancer therapy. Advanced culturing systems such as chip-based fluidic devices and bioprinting methods in combination with tumoroids have been used for high-throughput applications for personalized medicine. Even though organoid and tumoroid models are complex in vitro systems, validation of results in vivo is still the common practice. Here, we describe how both animal- and human-derived tumoroids have helped to identify novel vulnerabilities for cancer treatment in recent years, and how they are currently used for precision medicine.

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Section: Cellular Plasticity and Metastasismentioning

confidence: 99%

Section: Cellular Plasticity and Metastasismentioning

confidence: 99%

A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine

Kalla,

Pfneissl,

Mair

et al. 2024

Cell Oncol.

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show abstract

“…Animal models of skeletal metastasis are essential for understanding the pathogenesis of cancer bone metastases. There has been an increased interest in generating new threedimensional (3D) in vitro models including patient-derived xenograft models, organoid, and scaffold models that can mimic native bone microenvironment [176][177][178][179][180][181][182][183][184][185]. In addition, numerous new compounds have been evaluated for their effect and therapeutic potential on metastatic bone disease [186,187,[196][197][198][188][189][190][191][192][193][194][195].…”

Section: Novel Approaches To Treat Bone Metastasesmentioning

confidence: 99%

Muscle and Bone Defects in Metastatic Disease

Pauk

Saito

Hesse

et al. 2022

Curr Osteoporos Rep

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Purpose of Review The present review addresses most recently identified mechanisms implicated in metastasis-induced bone resorption and muscle-wasting syndrome, known as cachexia. Recent Findings Metastatic disease in bone and soft tissues is often associated with skeletal muscle defects. Recent studies have identified a number of secreted molecules and extracellular vesicles that contribute to cancer cell growth and metastasis leading to bone destruction and muscle atrophy. In addition, alterations in muscle microenvironment including dysfunctions in hepatic and mitochondrial metabolism have been implicated in cancer-induced regeneration defect and muscle loss. Moreover, we review novel in vitro and animal models including promising new drug candidates for bone metastases and cancer cachexia. Summary Preservation of bone health could be highly beneficial for maintaining muscle mass and function. Therefore, a better understanding of molecular pathways implicated in bone and muscle crosstalk in metastatic disease may provide new insights and identify new strategies to improve current anticancer therapeutics.

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Organoids of the male reproductive system: Challenges, opportunities, and their potential use in fertility research

Patrício

Santiago

Mano

et al. 2022

WIREs Mechanisms of Disease

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Organoids are units of function of a given organ able to reproduce, in culture, a biological structure similar in architecture and function to its counterpart in vivo. Today, it is possible to develop an organoid from a fragment of tissue, a stem cell located in an adult organ, an embryonic stem cell, or an induced pluripotent stem cell. In the past decade, many organoids have been developed which mimic stomach, pancreas, liver and brain tissues, optic cups, among many others. Additionally, different male reproductive system organs have already been developed as organoids, including the prostate and testis. These 3D cultures may be of great importance for urological cancer research and have the potential to be used in fertility research for the study of spermatozoa production and maturation, germ cells–somatic cells interactions, and mechanisms of disease. They also provide an accurate preclinical pipeline for drug testing and discovery, as well as for the study of drug resistance. In this work, we revise the current knowledge on organoid technology and its use in healthcare and research, describe the male reproductive system organoids and other biomaterials already developed, and discuss their current application. Finally, we highlight the research gaps, challenges, and opportunities in the field and propose strategies to improve the use of organoids for the study of male infertility situations. This article is categorized under: Reproductive System Diseases > Stem Cells and Development Reproductive System Diseases > Biomedical Engineering

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Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids

Cited by 8 publications

References 94 publications

A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine

A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine

Muscle and Bone Defects in Metastatic Disease

Organoids of the male reproductive system: Challenges, opportunities, and their potential use in fertility research

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