Novel diagnostic options for endometriosis – Based on the glycome and microbiome

Kovács, Zsuzsanna; Glover, Louise; Reidy, Fiona; MacSharry, John; Saldova, Radka

doi:10.1016/j.jare.2021.01.015

Cited by 24 publications

(30 citation statements)

References 145 publications

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“…There are no biomarkers in blood with sufficient efficacy to diagnose all forms of endometriosis ( 31 ). The only endometriosis-related blood test highlighted by a patient in this cohort was a test for elevated CA-125.…”

Section: Resultsmentioning

confidence: 99%

The experiences of endometriosis patients with diagnosis and treatment in New Zealand

Ellis

Munro

Wood

2022

Front. Glob. Womens Health

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Endometriosis is a chronically painful, invasive, inflammatory disease, with limited treatment options and long delays to diagnosis, which impacts 10% of females in New Zealand.IntroductionAs part of a larger group discussion study, this paper covers three themes associated with endometriosis patient experiences: intensity of pain, diagnostic tool shortcomings and perspectives of treatment options.Materials and methodsThe goal of this research was the inclusion of patient voices to guide research priorities. In early 2022, 50 New Zealand endometriosis patients participated in anonymous, asynchronous, text-based group discussions on the VisionsLive platform. The patients ranged in age from 18–48. The patients answered 50 questions, 23 text-based and 27 quantitative, and then took part in online group discussions.Results and discussionThe average age of symptom onset was 15.3 years, while the average delay from symptom onset to a working or surgically confirmed diagnosis was 7.91 years. The top five reported symptoms within the cohort were pain-based, and the participants discussed the many impacts of this pain on their work and education. The four main diagnostic tools employed on this cohort were abdominal ultrasound (72%), transvaginal ultrasound (68%), laparoscopy (82%) and sharing their symptom history with a medical practitioner (88%). The most common emotions patients experienced following receiving a diagnosis of endometriosis were relief (86%), feeling overwhelmed (54%), and anger (32%). The main treatments offered to this cohort were pain relief (96%), laparoscopic surgery (84%) and the combined oral contraceptive pill (80%). Of these three treatments, only laparoscopic surgery was viewed positively by the majority of users, with 67% considering laparoscopy an effective treatment, compared to 46% of users for pain relief, and 25% of users for the combined oral contraceptive pill.ConclusionsGathering the voice of patients revealed that long delays to diagnosis and dismissal by medical practitioners frequently manifests as a reaction of relief by patients once diagnosed. Results also showed treatment options such as pain relief and hormonal medications were often considered ineffective, but were routinely offered as the first, or only, options for patients. It is therefore important that both quicker routes to diagnosis and more effective treatment options be developed.

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Section: Resultsmentioning

confidence: 99%

The experiences of endometriosis patients with diagnosis and treatment in New Zealand

Ellis

Munro

Wood

2022

Front. Glob. Womens Health

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“…Relations between gut microbiota and diseases have gained more and more attention in recent decades ( Han et al., 2020 ; Kovács et al., 2021 ; Khoshkam et al., 2021 ; Walton et al., 2021 ). The significant changes of gut microbiota in MDD patients have been found in many studies ( Naseribafrouei et al., 2014 ; Jiang et al., 2015 ), including ours ( Zheng et al., 2016 ; Chen et al., 2018 ; Chen et al., 2020 ; Bai et al., 2021b ).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Bai

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveAlthough many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression.MethodsMajor depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors.ResultsFinally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs.ConclusionsOur results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression via affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.

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“…Gut microbiota plays an important role in maintaining the host’s health, and many researchers pay attention to the cross talk between the gut and brain ( Han et al., 2020 ; Qiao et al., 2020 ; Kovács et al., 2021 ; Khoshkam et al., 2021 ). Mounting evidence shows that gut microbiota can affect the host’s brain functions and behaviors via the “microbiota–gut–brain” axis ( Chen et al., 2021 ; Rajput et al., 2021 ; Ding et al., 2021 ; Dong et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Zhong

Chen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveIncreasing evidence shows a close relationship between gut microbiota and major depressive disorder (MDD), but the specific mechanisms remain unknown. This study was conducted to explore differential gut microbiota compositions related to the severity of MDD.MethodsHealthy controls (HC) (n = 131) and MDD patients (n = 130) were included. MDD patients with Hamilton Depression Rating Scale (HDRS) score <25 and ≥25 were assigned into moderate (n = 72) and severe (n = 58) MDD groups, respectively. Univariate and multivariate analyses were used to analyze the gut microbiota compositions at the genus level.ResultsThirty-six and 27 differential genera were identified in moderate and severe MDD patients, respectively. The differential genera in moderate and severe MDD patients mainly belonged to three (Firmicutes, Actinobacteriota, and Bacteroidota) and two phyla (Firmicutes and Bacteroidota), respectively. One specific covarying network from phylum Actinobacteriota was identified in moderate MDD patients. In addition, five genera (Collinsella, Eggerthella, Alistipes, Faecalibacterium, and Flavonifractor) from the shared differential genera by two MDD groups had a fair efficacy in diagnosing MDD from HC (AUC = 0.786).ConclusionsOur results were helpful for further exploring the role of gut microbiota in the pathogenesis of depression and developing objective diagnostic methods for MDD.

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Novel diagnostic options for endometriosis – Based on the glycome and microbiome

Cited by 24 publications

References 145 publications

The experiences of endometriosis patients with diagnosis and treatment in New Zealand

The experiences of endometriosis patients with diagnosis and treatment in New Zealand

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

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