Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Zhong, Qi; Chen, Jianjun; Wang, Ying; Shao, Wei; Zhou, Chanjuan; Xie, Peng

doi:10.3389/fcimb.2022.907239

Cited by 18 publications

(15 citation statements)

References 64 publications

(96 reference statements)

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“…If microbiota factors contribute to depression in people, then the microbiome (a genetic census of the microbiota) of depressed patients may display distinct signatures from that of healthy controls. Indeed, by comparing the microbiome of depressed patients versus healthy controls, changes in the abundance of certain bacteria taxa have been reported in many studies (Jiang et al, 2015;McGuinness et al, 2022;Radjabzadeh et al, 2022;Zhong et al, 2022). In agreement with the discovery of metagenomic signatures of depression, metaproteomics and metabolomics studies in mice and men also reveal significant depression-associated differences at the level of microbial-associated peptides and metabolites, the classes of compounds that interface microbe-host interactions (Yu et al, 2017;Chen et al, 2018;Valles-Colomer et al, 2019;Wu et al, 2020).…”

Section: Microbial Factors In Depressionmentioning

confidence: 72%

The microbiota-gut-brain axis in stress and depression

Tan

2023

Front. Neurosci.

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Humans and animals are evolved to have instinctive physiological responses to threats. The perception of threat by the brain triggers a multitude of changes across the brain and body. A large body of research have demonstrated that our hardwired survival instinct, the stress response, can become maladaptive and promote major depressive disorders and other neuropsychiatric impairments. However, gaps in our understanding of how chronic stress contributes to depression and mental disorders suggest that we also need to consider factors beyond the biology of the host. The unravelling of the structure and function of microorganisms that humans and animals are host to have driven a paradigm shift in understanding the individual as a collective network composed of the host plus microbes. Well over 90% of bacteria in the body reside in the large intestines, and these microbes in the lower gut function almost like an organ in the body in the way it interacts with the host. Importantly, bidirectional interactions between the gut microbiota and the brain (i.e., the two-way microbiota-gut-brain axis) have been implicated in the pathophysiology of mental disorders including depression. Here, in summarizing the emerging literature, we envisage that further research particularly on the efferent brain-gut-microbiota axis will uncover transformative links in the biology of stress and depression.

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Section: Microbial Factors In Depressionmentioning

confidence: 72%

The microbiota-gut-brain axis in stress and depression

Tan

2023

Front. Neurosci.

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“…At the genus level, the abundance of Alistipes , Alloprevotella , and Lleibacterium decreased significantly, and these changes were also observed in mice receiving FMT treatment. Alistipes , belonging to the family Rikenellaceae , has been shown to be significantly associated with depression ( Jiang et al, 2015 ; Zhong et al, 2022 ). Alistipes has also been linked to depression-like phenotypes in other mood disorders ( Domènech et al, 2022 ; Zhang et al, 2022a ).…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway

Liu

et al. 2023

Front. Microbiol.

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IntroductionDepression is a common mental disorder that affects approximately 350 million people worldwide. Much remains unknown about the molecular mechanisms underlying this complex disorder. Sigma-1 receptor (Sig-1R) is expressed at high levels in the central nervous system. Increasing evidence has demonstrated a close association between the Sig-1R and depression. Recently, research has suggested that the gut microbiota may play a crucial role in the development of depression.MethodsMale Sig-1R knockout (Sig-1R KO) and wild-type (WT) mice were used for this study. All transgenic mice were of a pure C57BL/6J background. Mice received a daily gavage of vancomycin (100 mg/kg), neomycin sulfate (200 mg/kg), metronidazole (200 mg/kg), and ampicillin (200 mg/kg) for one week to deplete gut microbiota. Fecal microbiota transplantation (FMT) was conducted to assess the effects of gut microbiota. Depression-like behaviors was evaluated by tail suspension test (TST), forced swimming test (FST) and sucrose preference test (SPT). Gut microbiota was analyzed by 16s rRNA and hippocampal transcriptome changes were assessed by RNA-seq.ResultsWe found that Sig-1R knockout induced depression-like behaviors in mice, including a significant reduction in immobility time and an increase in latency to immobility in the FST and TST, which was reversed upon clearance of gut microbiota with antibiotic treatment. Sig-1R knockout significantly altered the composition of the gut microbiota. At the genus level, the abundance of Alistipes, Alloprevotella, and Lleibacterium decreased significantly. Gut microbiota dysfunction and depression-like phenotypes in Sig-1R knockout mice could be reproduced through FMT experiments. Additionally, hippocampal RNA sequencing identified multiple KEGG pathways that are associated with depression. We also discovered that the cAMP/CREB/BDNF signaling pathway is inhibited in the Sig-1R KO group along with lower expression of neurotrophic factors including CTNF, TGF-α and NGF. Fecal bacteria transplantation from Sig-1R KO mice also inhibited cAMP/CREB/BDNF signaling pathway.DiscussionIn our study, we found that the gut-brain axis may be a potential mechanism through which Sig-1R regulates depression-like behaviors. Our study provides new insights into the mechanisms by which Sig-1R regulates depression and further supports the concept of the gut-brain axis.

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“…It is well known that this bacterium is involved in the production of butyric acid, the main SCFA produced by the intestinal flora [ 80 ]. Moreover, in the studies involving patients with major depressive disorder (MDD), this bacterium was identified as a potential MDD biomarker [ 81 ]. Similarly, Zhou et al [ 82 ] showed that both Faecalibacterium and Butyricicoccus may be important in diagnosing and treating patients suffering from postpartum depression.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Diet Enriched with Jerusalem artichoke, Inulin, and Fluoxetine on Cognitive Functions, Neurogenesis, and the Composition of the Intestinal Microbiota in Mice

Szewczyk

Andres-Mach

Zagaja

et al. 2023

CIMB

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The aim of the study was to assess the effect of long-term administration of natural prebiotics: Jerusalem artichoke (topinambur, TPB) and inulin (INU) as well as one of the most popular antidepressants, fluoxetine (FLU), on the proliferation of neural stem cells, learning and memory functions, and the composition of the intestinal microbiota in mice. Cognitive functions were assessed using the Morris Water Maze (MWM)Test. Cells were counted using a confocal microscope and ImageJ software. We performed 16S rRNA sequencing to assess changes in the gut microbiome of the mice. The obtained results showed that the 10-week supplementation with TPB (250 mg/kg) and INU (66 mg/kg) stimulates the growth of probiotic bacteria, does not affect the learning and memory process, and does not disturb the proliferation of neural stem cells in the tested animals. Based on this data, we can assume that both TPB and INU seem to be safe for the proper course of neurogenesis. However, 2-week administration of FLU confirmed an inhibitory impact on Lactobacillus growth and negatively affected behavioral function and neurogenesis in healthy animals. The above studies suggest that the natural prebiotics TPB and INU, as natural supplements, may have the potential to enrich the diversity of intestinal microbiota, which may be beneficial for the BGM axis, cognitive functions, and neurogenesis.

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Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Cited by 18 publications

References 64 publications

The microbiota-gut-brain axis in stress and depression

The microbiota-gut-brain axis in stress and depression

Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway

The Effect of a Diet Enriched with Jerusalem artichoke, Inulin, and Fluoxetine on Cognitive Functions, Neurogenesis, and the Composition of the Intestinal Microbiota in Mice

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