Novel design of sodium alginate based absorbable stent for the use in urethral stricture disease

Klekiel, Tomasz; Mackiewicz, Agnieszka; Kaczmarek-Pawelska, Agnieszka; Skonieczna, Joanna; Kurowiak, Jagoda; Piasecki, Tomasz; Noszczyk-Nowak, Agnieszka; Będziński, R.

doi:10.1016/j.jmrt.2020.06.047

Cited by 14 publications

(16 citation statements)

References 36 publications

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“…Currently, the most popular treating method used for the narrowing of the urethral canal is stenting, which has systematically been improved by introducing new solutions. Until now, metal or aluminum stents have been the most commonly used [ 15 , 16 , 17 ], but, today, researchers are looking for better solutions, including those based on the stents from biodegradable materials [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. The evolution of stents dedicated to the genitourinary system for both the ureter and the urethra has been very intense.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Selected Properties of Sodium Alginate-Based Hydrogel Material—Mechanical Strength, μDIC Analysis and Degradation

et al. 2022

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The search for ideal solutions for the treatment of urethral stenosis continues. This includes developing the material, design, while maintaining its optimal and desired properties. This paper presents the results of the research conducted on sodium alginate-based hydrogel material (AHM), which may be used as a material for stents dedicated to the treatment of pathologies occurring in the genitourinary system. In order to determine the selected parameters of the AHM samples, strength and degradation tests, as well as analysis of the micro changes occurring on the surface of the material using a digital image correlation (µDIC) system, were performed. This study shows that the material possessed good mechanical strength parameters, the knowledge of which is particularly important from the point of view of the stent–tissue interaction. The degradation analysis performed showed that the AHM samples degrade in an artificial urine environment, and that the degradation time mainly depends on the chemical composition of the material. The novel µDIC method performed allowed us to characterize the homogeneity of the material structure depending on the cross-linking agent used.

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Section: Introductionmentioning

confidence: 99%

“…One of the bioresorbable materials of urological stents is sodium alginate (SA) [ 3 , 21 , 22 , 35 , 36 ]. Hydrogel materials based on sodium alginate are primarily bio- and cytocompatible, biodegradable and exhibit antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Selected Properties of Sodium Alginate-Based Hydrogel Material—Mechanical Strength, μDIC Analysis and Degradation

et al. 2022

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“…In these studies, the analysis of mechanical characteristics of a normal urethra was carried out in order to determine the constitutive relationships between the material and deformability. This knowledge became essential for the proper development of a numerical model of the tissue–stent interaction [ 28 ]. Fragments of the urethra (in axial and radial direction) or the entire urethra of a horse were used for the testing purposes.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, a too rigid and nondeformable stent construction may cause too much pressure on the urethra walls. In consequence, it will cause local overload leading to fibrosis [ 28 ]. In order to develop the optimal solution, it is first necessary to know the actual deformation characteristics of the organ itself, i.e., the urethra under conditions of static and flow.…”

Section: Introductionmentioning

confidence: 99%

Determination of Stent Load Conditions in New Zealand White Rabbit Urethra

Mackiewicz

Klekiel

Kurowiak

et al. 2020

JFB

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Background: Frequency of urethral stenosis makes it necessary to develop new innovative methods of treating this disease. This pathology most often occurs in men and manifests itself in painful urination, reduced urine flow, or total urinary retention. This is a condition that requires immediate medical intervention. Methods: Experimental tests were carried out on a rabbit in order to determine the changes of pressure in the urethra system and to estimate the velocity of urine flow. For this purpose, a measuring system was proposed to measure the pressure of a fluid-filled urethra. A fluoroscope was used to observe the deformability of the bladder and urethra canal. Results: Based on these tests, the range of changes in the urethra tube diameter, the pressures inside the system, and the flow velocity during micturition were determined. Conclusions: The presented studies allowed determining the behavior of the urethra under the conditions of urinary filling. The fluid-filled bladder and urethra increased their dimensions significantly. Such large changes require that the stents used for the treatment of urethral stenosis should not have a fixed diameter but should adapt to changing urethral dimensions.

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“…After the preliminary study, a corresponding study was performed on canine CT. After collecting each heart, the mitral valve was dissected and rinsed with Biolasol solution (Biochefa, Sosnowiec, Poland), and CT were collected for further analysis. The Biolasol solution preserves the tissue and does not change its mechanical properties [26][27][28][29]. At least two CT from each valve leaflet were collected for histopathological examination and fixed with 7% buffered formalin solution for 24 h. The tissues were fixed at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Biomechanical–Structural Correlation of Chordae tendineae in Animal Models: A Pilot Study

Gach

Janus

Mackiewicz

et al. 2021

Animals

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The mitral valve apparatus is a complex structure consisting of the mitral ring, valve leaflets, papillary muscles and chordae tendineae (CT). The latter are mainly responsible for the mechanical functions of the valve. Our study included investigations of the biomechanical and structural properties of CT collected from canine and porcine hearts, as there are no studies about these properties of canine CT. We performed a static uniaxial tensile test on CT samples and a histopathological analysis in order to examine their microstructure. The results were analyzed to clarify whether the changes in mechanical persistence of chordae tendineae are combined with the alterations in their structure. This study offers clinical insight for future research, allowing for an understanding of the process of chordae tendineae rupture that happens during degenerative mitral valve disease—the most common heart disease in dogs.

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Novel design of sodium alginate based absorbable stent for the use in urethral stricture disease

Cited by 14 publications

References 36 publications

Evaluation of Selected Properties of Sodium Alginate-Based Hydrogel Material—Mechanical Strength, μDIC Analysis and Degradation

Evaluation of Selected Properties of Sodium Alginate-Based Hydrogel Material—Mechanical Strength, μDIC Analysis and Degradation

Determination of Stent Load Conditions in New Zealand White Rabbit Urethra

Biomechanical–Structural Correlation of Chordae tendineae in Animal Models: A Pilot Study

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