Novel dam-like effect based on piezoelectric energy conversion for drug sustained release of drug-loaded TiO2 @ BaTiO3 coaxial nanotube coating

Wu, Cong; Wei, Xiao-Gang; Zhao, Kang; Jiang, Junyi; Jiao, Mengzhen; Cheng, Junhua; Tang, Zhi; Guo, Zheng; Tang, Yufei

doi:10.1016/j.ceramint.2021.03.073

Cited by 13 publications

(3 citation statements)

References 44 publications

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“…Also, the polarized VMH/TiO 2 @BaTiO 3 co‐axial nanotubes showed long‐term antibacterial efficacy on S. aureus . [ 212 ] The association of BaTiO 3 could be useful in providing additional features like sustained release of drugs, antimicrobial properties to the already existing delivery systems, marking its utility as a potent carrier platform.…”

Section: Batio3 Nanoparticles‐based Nanocomposites and Their Applicat...mentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

Desseigne

Dev

et al. 2022

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Stimulation of cells with electrical cues is an imperative approach to interact with biological systems and has been exploited in clinical practices over a wide range of pathological ailments. This bioelectric interface has been extensively explored with the help of piezoelectric materials, leading to remarkable advancement in the past two decades. Among other members of this fraternity, colloidal perovskite barium titanate (BaTiO3) has gained substantial interest due to its noteworthy properties which includes high dielectric constant and excellent ferroelectric properties along with acceptable biocompatibility. Significant progression is witnessed for BaTiO3 nanoparticles (BaTiO3 NPs) as potent candidates for biomedical applications and in wearable bioelectronics, making them a promising personal healthcare platform. The current review highlights the nanostructured piezoelectric bio interface of BaTiO3 NPs in applications comprising drug delivery, tissue engineering, bioimaging, bioelectronics, and wearable devices. Particular attention has been dedicated toward the fabrication routes of BaTiO3 NPs along with different approaches for its surface modifications. This review offers a comprehensive discussion on the utility of BaTiO3 NPs as active devices rather than passive structural unit behaving as carriers for biomolecules. The employment of BaTiO3 NPs presents new scenarios and opportunity in the vast field of nanomedicines for biomedical applications.

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Section: Batio3 Nanoparticles‐based Nanocomposites and Their Applicat...mentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

Desseigne

Dev

et al. 2022

Small

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“…Based on the chemical composition, the green glaze of all five pieces is identified as a silica-aluminum oxide-lead oxide (SiO 2 -Al 2 O 3 -PbO) low-temperature glaze, with Pb 2+ as the main flux and divalent copper ions (Cu 2+ ) as the main colorant. bond lengths and a larger effective volume, a more open cage structure, and places fewer geometric and energetic restrictions on ion movement and exchange (that is, the electron density and activation energy are lower) [54][55][56]. Therefore, green lead glazes with Cu 2+ as the colorant are more susceptible to corrosion than yellow lead glazes with Fe 3+ as the colorant.…”

Section: Chemical Compositions Of the Pristine Glazesmentioning

confidence: 99%

Corrosion of glaze in the marine environment: study on the green-glazed pottery from the Southern Song “Nanhai I” shipwreck (1127–1279 A.D.)

Zhou

Zhang³

et al. 2023

Herit Sci

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The “Nanhai I” shipwreck is an important discovery in the underwater archaeology of China, and many ceramics have been unearthed. These ceramics are important material artifacts of China’s “Maritime Silk Road” and have considerable significance for the study of foreign trade in the Southern Song Dynasty (1127–1279 A.D.). However, these ceramics have been buried in a marine environment for approximately 800 years and have all been corroded to varying degrees, with green-glazed pottery being the most severely corroded. In this study, the chemical compositions of five samples of green-glazed pottery and the corrosion morphology and mechanism of a representative sample were analyzed by optical microscopy, scanning electron microscopy-energy dispersive X‐ray spectrometry (SEM–EDS), Raman spectroscopy, and X-ray diffraction (XRD). Results: The green glaze is a low-temperature silica-aluminum oxide-lead oxide (SiO2-Al2O3-PbO) glaze with copper ions (Cu2+) as the main colorant. The corrosion morphology is characterized by alternating silicon (Si)- and lead (Pb)-rich layers, a sharp reaction interface between the Si-rich layer and the pristine glaze, and a relatively high porosity of the Si-rich gel layer, which is formed by the accumulation of spherical hydrated silica colloidal particles. These features suggest that the glaze was corroded through an interface-coupled dissolution–precipitation mechanism and that the properties of the gel pores controlled the reaction kinetics. Fluctuations in the solution properties at the reaction interface produced the complex morphology of the gel layer, whereas changes in the dryness and humidity of the environment are not essential factors. The samples have been corroding in the marine environment for nearly a thousand years, and explorations of the corrosion morphology and mechanism could provide reference information on the corrosion of various ancient ceramics and glasses and a basis for scientific conservation of these objects.

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“…Thus, it is not strange that nanomaterials and nanotechnologies have played important roles in modernizing traditional Chinese medicine [29,30]. Among different sorts of nanomaterials, polymer-based medicated films are one of the most popular ones [31][32][33][34], and show some advantages over other nanoproducts such as nanocrystals, nanolipids and inorganic nanocomposites in terms of processability, availability and feasibility [35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Hybrid Films for Fast and Convenient Delivery of Active Herb Extracts

et al. 2022

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Herb medicines are popular for safe application due to being a source of natural herbs. However, how to deliver them in an efficacious and convenient manner poses a big challenge to researchers. In this study, a new concept is demonstrated that the electrospun polymer-based hybrid films can be a platform for promoting the delivery of a mixture of active herb extract, i.e., Lianhua Qingwen Keli (LQK), also a commercial traditional Chinese patent medicine. The LQK can be co-dissolved with the filament-forming polymeric polyvinylpyrrolidone K60 and a sweeter sucralose to prepare an electrospinnable solution. A handheld electrospinning apparatus was explored to transfer the solution into solid nanofibers, i.e., the LQK-loaded medicated films. These films were demonstrated to be composed of linear nanofibers. A puncher was utilized to transfer the mat into circular membrane a diameter of 15 mm. Two self-created methods were developed for disclosing the dissolution performances of the electrospun mats. Both the water droplet experiments and the wet paper (mimic tongue) experiments verified that the hybrid films can rapidly disintegrate when they encounter water and release the loaded LQK in an immediate manner. Based on the reasonable selections of polymeric excipients, the present protocols pave a way for delivering many types of active herb extracts in an effective and convenient manner.

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Novel dam-like effect based on piezoelectric energy conversion for drug sustained release of drug-loaded TiO2 @ BaTiO3 coaxial nanotube coating

Cited by 13 publications

References 44 publications

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Corrosion of glaze in the marine environment: study on the green-glazed pottery from the Southern Song “Nanhai I” shipwreck (1127–1279 A.D.)

Electrospun Hybrid Films for Fast and Convenient Delivery of Active Herb Extracts

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