Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China

Liao, Xuelian; Wang, Bo; Kang, Yan

doi:10.1007/s00134-020-05954-2

Cited by 228 publications

(232 citation statements)

References 9 publications

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“…The national early warning score (NEWS) for COVID-19 patients, was collected upon ward admission and during follow up. The NEWS score was calculated based on the following parameters: age, respiratory rate, oxygen saturation, temperature, systolic blood pressure, pulse rate and level of consciousness [20]. We defined three risk categories for clinical deterioration: low score (NEWS 0-4), medium score (NEWS 5-6), and high score (NEWS≥7) for COVID patients.…”

Section: Clinical Classification and Clinical Follow-upmentioning

confidence: 99%

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Gautret

Lagier

Parola

et al. 2020

Travel Medicine and Infectious Disease

691

837

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Background:We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration. Methods: We conducted an uncontrolled non-comparative observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU). Results: All patients improved clinically except one 86 year-old patient who died, and one 74 year-old patient still in intensive care. A rapid fall of nasopharyngeal viral load was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% of patients at Day5. Consequently patients were able to be rapidly discharged from IDU with a mean length of stay of five days. Conclusion:We believe there is urgency to evaluate the effectiveness of this potentially-life saving therapeutic strategy at a larger scale, both to treat and cure patients at an early stage before irreversible severe respiratory complications take hold and to decrease duration of carriage and avoid the spread of the disease. Furthermore, the cost of treatment is negligible.

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Section: Clinical Classification and Clinical Follow-upmentioning

confidence: 99%

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Gautret

Lagier

Parola

et al. 2020

Travel Medicine and Infectious Disease

691

837

View full text Add to dashboard Cite

show abstract

“…Although these preliminary data are insufficient to draw a clinical overview of the patients affected with this viral respiratory illness novel to humans, it is obvious that COVID-19 could cause severe respiratory failure requiring ICU admission. The first experiences of our Chinese colleagues are described in this journal [7].…”

Section: Incubation Period and Clinical Descriptionmentioning

confidence: 99%

Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists

et al. 2020

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“…This surge of critically ill patients in designated hospitals as well as fever clinics represents urgent demands for intensive care with regards to space, supplies, and staff (Table 1) [5][6][7][8]. Response to these demands requires cooperation between the medical rescue team, infection control specialists, local health authorities, and center for disease control and prevention [9].…”

mentioning

confidence: 99%

Intensive care during the coronavirus epidemic

et al. 2020

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Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China

Cited by 228 publications

References 9 publications

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study

Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists

Intensive care during the coronavirus epidemic

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