Novel corona virus (COVID-19) pandemic: current status and possible strategies for detection and treatment of the disease

Bhagat, Stuti; Yadav, Nisha; Shah, Juhi; Dave, Harsh; Swaraj, Shachee; Tripathi, Shashank; Singh, Sanjay

doi:10.1080/14787210.2021.1835469

Cited by 23 publications

(15 citation statements)

References 154 publications

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“…Point-of-care devices have been one widely-used way for detection of COVID-19. Such devices can take about 5-10 min to produce results [16]. However, the downside of these approaches is that they require some samples (e.g., blood or saliva) from the patient.…”

Section: Discussionmentioning

confidence: 99%

“…The most common symptoms of COVID-19 are: fever, dry cough, and fatigue [11][12][13][14][15]. Other less common symptoms, like wheezing and pain, nasal congestion, headache, arthritis, sore throat, diarrhea, loss of taste or smell and rash or discoloration of the fingers or toes, may be observed in some cases [16][17][18]. These symptoms, appearing gradually, are usually mild.…”

Section: Introductionmentioning

confidence: 99%

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An IoT Framework for Screening of COVID-19 Using Real-Time Data from Wearable Sensors

Mukhtar

Rubaiee

Krichen

et al. 2021

IJERPH

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Experts have predicted that COVID-19 may prevail for many months or even years before it can be completely eliminated. A major problem in its cure is its early screening and detection, which will decide on its treatment. Due to the fast contactless spreading of the virus, its screening is unusually difficult. Moreover, the results of COVID-19 tests may take up to 48 h. That is enough time for the virus to worsen the health of the affected person. The health community needs effective means for identification of the virus in the shortest possible time. In this study, we invent a medical device utilized consisting of composable sensors to monitor remotely and in real-time the health status of those who have symptoms of the coronavirus or those infected with it. The device comprises wearable medical sensors integrated using the Arduino hardware interfacing and a smartphone application. An IoT framework is deployed at the backend through which various devices can communicate in real-time. The medical device is applied to determine the patient’s critical status of the effects of the coronavirus or its symptoms using heartbeat, cough, temperature and Oxygen concentration (SpO2) that are evaluated using our custom algorithm. Until now, it has been found that many coronavirus patients remain asymptomatic, but in case of known symptoms, a person can be quickly identified with our device. It also allows doctors to examine their patients without the need for physical direct contact with them to reduce the possibility of infection. Our solution uses rule-based decision-making based on the physiological data of a person obtained through sensors. These rules allow to classify a person as healthy or having a possibility of infection by the coronavirus. The advantage of using rules for patient’s classification is that the rules can be updated as new findings emerge from time to time. In this article, we explain the details of the sensors, the smartphone application, and the associated IoT framework for real-time, remote screening of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An IoT Framework for Screening of COVID-19 Using Real-Time Data from Wearable Sensors

Mukhtar

Rubaiee

Krichen

et al. 2021

IJERPH

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“…Several curative strategies such as combination treatment with systemic corticosteroids (dexamethasone), oxygen therapy, convalescent plasma from recovered COVID-19 patients, drugs such as tocilizumab, hydroxychloroquine, and remdesivir were deployed against SARS-CoV-2 as no definitive vaccine and vaccination strategy were available [12]. However, their impact on individuals with OC or any other cancer types remains to be established.…”

Section: Covid-19 Mrna Vaccine Inflammation and Effects On Ovarian Cmentioning

confidence: 99%

Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection

et al. 2021

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Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide is a major public health concern. Cancer patients are considered a vulnerable population to SARS-CoV-2 infection and may develop several COVID-19 symptoms. The heightened immunocompromised state, prolonged chronic pro-inflammatory milieu coupled with comorbid conditions are shared in both disease conditions and may influence patient outcome. Although ovarian cancer (OC) and COVID-19 are diseases of entirely different primary organs, both diseases share similar molecular and cellular characteristics in their microenvironment suggesting a potential cooperativity leading to poor outcome. In COVID-19 related cases, hospitalizations and deaths worldwide are lower in women than in males; however, comorbidities associated with OC may increase the COVID-19 risk in women. The women at the age of 50-60 years are at greater risk of developing OC as well as SARS-CoV-2 infection. Increased levels of gonadotropin and androgen, dysregulated renin-angiotensin-aldosterone system (RAAS), hyper-coagulation and chronic inflammation are common conditions observed among OC and severe cases of COVID-19. The upregulation of common inflammatory cytokines and chemokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-2, IL-6, IL-10, interferon-γ-inducible protein 10 (IP-10), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), macrophage colony-stimulating factor (M-CSF), among others in the sera of COVID-19 and OC subjects suggests potentially similar mechanism(s) involved in the hyper-inflammatory condition observed in both disease states. Thus, it is conceivable that the pathogenesis of OC may significantly contribute to the potential infection by SARS-CoV-2. Our understanding of the influence and mechanisms of SARS-CoV-2 infection on OC is at an early stage and in this article, we review the underlying pathogenesis presented by various comorbidities of OC and correlate their influence on SARS-CoV-2 infection.

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“…The mandatory data is insufficient for this vaccine development because (i) the S protein in the virus is given good ground for expecting antigen, on the other hand, best or most effective use design a most favorable immune response and some debates like targeted to the receptor-binding area otherwise full length of the protein, (ii) the severe acute respiratory syndrome (SARS), as well as the Middle East respiratory syndrome (MERS) vaccine development, resulted in exacerbated lung disease and also adverse type 2 helper T cell responses, (iii) single-dose vaccines will be and the possible period of immunity is unknown. From a safety point of view vaccine development is a lengthy process [ 8 ].…”

Section: Up-to-date Information On Covid-19 Drugs and Vaccinationmentioning

confidence: 99%

“…The infection is spread from human to human [ 5 ] and through contacting infected droplets released into the surroundings by coughing and sneezing, as well as contact spread through the mouth, nasal, and ocular mucous [ 6 ]. For COVID-19 infection, common symptoms include fever, dry cough, tiredness, breathing difficulty, body pain, chills, sore throat, headache, weight loss, gastric disturbance, loss of smell and taste, skin rashes, and discoloration of toes and fingers [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect on the Immune System in the Human Body Due to COVID-19: An Insight on Traditional to Modern Approach as a Preventive Measure

Sutradhar¹,

Sarkar

2021

J Pharmacopuncture

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The COVID-19, the most infectious pandemic disease arising due to SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has caused huge issues globally. In this review, we discuss the impact of COVID-19 on the immune system of the human body and the protective mechanisms of the host immune system opposing viral infections. Here, we summarize the effect of the pandemic of the novel coronavirus disease on the immune system such as sleep and Behavioral Immune System (BIS) together with consideration of researcher’s observation points of view. We draw particular attention to recent up-to-date reports concerning COVID-19 drugs as well as information about the landscape document for COVID-19 vaccines released by WHO (World Health Organization), and some adverse events of COVID-19 vaccination. Additionally, can take part in the preventive appraise in opposition within this pandemic severe COVID-19 infections disease may affect some outcome in physical exercise, physical movement, healthy diets, and good nutrition are significant for supporting the immune systems and summarize AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy) Indian medicinal systems guidelines for immunity boosting procedures during COVID-19 pandemic.

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Novel corona virus (COVID-19) pandemic: current status and possible strategies for detection and treatment of the disease

Cited by 23 publications

References 154 publications

An IoT Framework for Screening of COVID-19 Using Real-Time Data from Wearable Sensors

An IoT Framework for Screening of COVID-19 Using Real-Time Data from Wearable Sensors

Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection

The Effect on the Immune System in the Human Body Due to COVID-19: An Insight on Traditional to Modern Approach as a Preventive Measure

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