Novel Copper-Based Therapeutic Agent for Anti-Inflammatory: Synthesis, Characterization, and Biochemical Activities of Copper(II) Complexes of Hydroxyflavone Schiff Bases

Joseph, J.; Nagashri, K.

doi:10.1007/s12010-011-9529-z

Cited by 21 publications

(14 citation statements)

References 23 publications

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“…This peak indicates that phenolic compounds and their derivatives are still present in the ZVI material. Around 200 nm, a typical peak of benzoyl in flavonoid compounds is shown from tea extract [ 58 ]. Other compounds besides polyphenols identified in ZVI were present since the extract used was not pure isolate.…”

Section: Resultsmentioning

confidence: 99%

Green Production of Zero-Valent Iron (ZVI) Using Tea-Leaf Extracts for Fenton Degradation of Mixed Rhodamine B and Methyl Orange Dyes

et al. 2022

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The danger from the content of dyes produced by textile-industry waste can cause environmental degradation when not appropriately treated. However, existing waste-treatment methods have not been effective in degrading dyes in textile waste. Zero-valent iron (ZVI), which has been widely used for wastewater treatment, needs to be developed to acquire effective green production. Tea (Camellia sinensis) leaves contain many polyphenolic compounds used as natural reducing agents. Therefore, this study aims to synthesize ZVI using biological reducing agents from tea-leaf extract and apply the Fenton method to degrade the color mixture of rhodamine B and methyl orange. The results show that the highest polyphenols were obtained from tea extract by heating to 90 °C for 80 min. Furthermore, PSA results show that ZVI had a homogeneous size of iron and tea extract at a volume ratio of 1:3. The SEM-EDS results show that all samples had agglomerated particles. The ZVI 1:1 showed the best results, with a 100% decrease in the color intensity of the dye mixture for 60 min of reaction and a degradation percentage of 100% and 66.47% for rhodamine B and methyl orange from LC-MS analysis, respectively. Finally, the decrease in COD value by ZVI was 92.11%, higher than the 47.36% decrease obtained using Fe(II).

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Section: Resultsmentioning

confidence: 99%

Green Production of Zero-Valent Iron (ZVI) Using Tea-Leaf Extracts for Fenton Degradation of Mixed Rhodamine B and Methyl Orange Dyes

et al. 2022

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“…Biochemical action of copper’s complexes with non-steroidal anti-inflammatory drugs (NSAIDs) has been recently studied. Numerous Cu(II) complexes of NSAIDs, showing enhanced anti-inflammatory and antiulcerogenic activity as well as reduced gastrointestinal toxicity compared to the un-complexed drug have been prepared and structurally characterized (Joseph and Nagashri 2012). It is likely that copper complexes interact with enzymes and inhibit vital cell functions, rather than interact with DNA and induce crosslinking (Iakovidis et al 2011).…”

Section: Complexes Of Coppermentioning

confidence: 99%

The many “faces” of copper in medicine and treatment

2014

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Copper (Cu) is an essential microelement found in all living organisms with the unique ability to adopt two different redox states—in the oxidized (Cu2+) and reduced (Cu+). It is required for survival and serves as an important catalytic cofactor in redox chemistry for proteins that carry out fundamental biological functions, important in growth and development. The deficit of copper can result in impaired energy production, abnormal glucose and cholesterol metabolism, increased oxidative damage, increased tissue iron (Fe) accrual, altered structure and function of circulating blood and immune cells, abnormal neuropeptides synthesis and processing, aberrant cardiac electrophysiology, impaired myocardial contractility, and persistent effects on the neurobehavioral and the immune system. Increased copper level has been found in several disorders like e.g.: Wilson’s disease or Menke’s disease. New findings with the great potential for impact in medicine include the use of copper-lowering therapy for antiangiogenesis, antifibrotic and anti-inflammatory purposes. The role of copper in formation of amyloid plaques in Alzheimer’s disease, and successful treatment of this disorder in rodent model by copper chelating are also of interest. In this work we will try to describe essential aspects of copper in chosen diseases. We will represent the evidence available on adverse effect derived from copper deficiency and copper excess. We will try to review also the copper biomarkers (chosen enzymes) that help reflect the level of copper in the body.

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“…The shortage of new antimicrobial drugs and increasing resistance of bacteria to antimicrobial agents have been of some concern [14][15][16]. A number of research programs have been aimed at increasing the antimicrobial performances of molecules by introducing new molecular parameters such as heteroatoms [17][18][19], chemical functions [20,21], and aromatics [22,23]. The formulation studies of new antibacterial and antifungal agents have been an active research field.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Ionic Liquids with Fumarate Anion

Zhou

et al. 2013

Journal of Chemistry

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The shortage of new antimicrobial drugs and increasing resistance of microbe to antimicrobial agents have been of some concern. The formulation studies of new antibacterial and antifungal agents have been an active research field. Ionic liquids are known as designed liquids with controllable physical/chemical/biological properties and specific functions, which have been attracting considerable interest over recent years. However, no attention has been made towards the preparation of ionic liquids with antimicrobial activities. In this paper, a new class of ionic liquids (ILs) with fumarate anion was synthesized by neutralization of aqueous 1-butyl-3-methylimidazolium hydroxide with equimolar monoester fumarate and characterized using NMR and thermal gravimetric analysis. The ILs are soluble in water and polar organic solvents and also soluble in the common ILs. The antimicrobial activities of the ILs are more active than commercially available potassium sorbate and are greatly affected by the alkyl chain length. The significant antimicrobial properties observed in this research suggest that the ILs may have potential applications in the modern biotechnology.

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Novel Copper-Based Therapeutic Agent for Anti-Inflammatory: Synthesis, Characterization, and Biochemical Activities of Copper(II) Complexes of Hydroxyflavone Schiff Bases

Cited by 21 publications

References 23 publications

Green Production of Zero-Valent Iron (ZVI) Using Tea-Leaf Extracts for Fenton Degradation of Mixed Rhodamine B and Methyl Orange Dyes

Green Production of Zero-Valent Iron (ZVI) Using Tea-Leaf Extracts for Fenton Degradation of Mixed Rhodamine B and Methyl Orange Dyes

The many “faces” of copper in medicine and treatment

Antimicrobial Ionic Liquids with Fumarate Anion

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