Novel Compliance Index derived from digital volume pulse associated with risk factors and exercise capacity in patients undergoing treadmill exercise tests

Chen, Ju‐Yi; Tsai, Wei-Chuan; Wu, Ming-Sheng; Hsu, Chih‐Hsin; Lin, Chih‐Chan; Wu, Hsien‐Tsai; Lin, Li-Jen; Chen, Jyh-Hong

doi:10.1097/hjh.0b013e328244e3ac

Cited by 17 publications

(21 citation statements)

References 22 publications

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“…22) CI, derived from our photoplethysmography system, may be clinically useful for evaluating arterial stiffness of small to medium sized arteries. 14,15) We showed that both large and small arterial stiffening occurs in pre-DM patients in the current study. In Table III of our study, we found that the HOMA index, rather than fasting glucose and HbA 1C , was an independent determinant for CI after adjusting for important confounders.…”

Section: Discussionmentioning

confidence: 80%

“…31,32) We have previously showed that CI was lower in patients with risk factors and was associated with poor exercise capacity. 14) This index may be clinically useful for evaluating exercise capacity related to peripheral arterial stiffness.…”

Section: Possible Mechanisms Of Increased Arterial Stiffness In Pre-dmmentioning

confidence: 99%

“…14,15) The stiffness index (SI), calculated from the digital volume pulse (DVP) measured by photoplethysmography, is an index of wave refl ections and also an acceptable marker for large arterial stiffness. 16,17) According to the 2010 American Diabetes Association (ADA) guideline for diagnosis and classifi cation of DM, 18) pre-DM patients have a HbA 1C level between 5.7% to 6.4%.…”

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confidence: 99%

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Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

et al. 2013

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SummaryPremature arteriosclerosis may be one of the mechanisms linking pre-diabetes mellitus (pre-DM) and cardiovascular disease. We sought to characterize premature arteriosclerosis in pre-DM using different arterial stiffness indices and to fi nd the independent contributors of this process. We recruited 33 patients without DM, 53 patients with pre-DM, and 34 subjects with DM. Both the compliance index (CI) and stiffness index (SI) were measured. Patients with pre-DM and DM had lower CI (3.8 ± 2.1 versus 5.2 ± 3.0 units; P < 0.05 and 3.6 ± 1.8 versus 5.2 ± 3.0 units; P < 0.05, respectively) and higher SI (8.0 ± 2.0 versus 6.7 ± 1.6 m/s; P < 0.01 and 9.4 ± 2.3 versus 6.7 ± 1.6 m/s; P < 0.001, respectively) than patients without DM. Using multivariate linear regression analysis, age, heart rate, and HOMA index were independent determinants for SI (whole model: R 2 = 0.47, P < 0.001), whereas male gender, hsCRP, and HOMA index were independent determinants for CI (whole model: R 2 = 0.34, P < 0.01). The HOMA index was an independent determinant for arterial stiffness. Increased insulin resistance may associate with increased arterial stiffness at peripheral arteries in pre-DM patients. (Int Heart J 2013; 54: 27-32)

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Section: Discussionmentioning

confidence: 80%

Section: Possible Mechanisms Of Increased Arterial Stiffness In Pre-dmmentioning

confidence: 99%

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confidence: 99%

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Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

et al. 2013

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“…Although no differences in age and HR were found, the mean BP was different between groups (Table VI in the online-only Data Supplement). Two arterial stiffness indices, stiffness index and compliance index, 20,21 were measured. Obese and overweight subjects showed trends toward higher stiffness index than normal weight subjects ( Figure 6C).…”

Section: Arterial Stiffening and Lower Lox Levels In Obese Humansmentioning

confidence: 99%

Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity

Chen¹,

Tsai²,

Tai

et al. 2013

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Objective-One potential mechanism through which obesity exerts adverse effects on the vascular system is by increasing aortic stiffness, a change known to be predictive of increased cardiovascular mortality. The aim of this study was to investigate the pathophysiology that links obesity to aortic stiffening. Approach and Results-Obese (ob/ob) mice were used to examine physical, morphological, and molecular changes in the aorta in response to obesity. ob/ob mice had increased aortic pulse wave velocity and tissue rigidity. ob/ob aorta exhibited decreases of lysyl oxidase (LOX) activity and cross-linked elastin, and increases of elastin fragmentation and elastolytic activity. The aortas of ob/ob mice were surrounded by a significant amount of proinflammatory and pro-oxidative perivascular adipose tissue. In vitro studies revealed that the conditioned medium from differentiated adipocytes or the perivascular adipose tissue of ob/ob mice attenuated LOX activity. Furthermore, inhibition of LOX in wild-type lean mice caused elastin fragmentation and induced a significant increase in pulse wave velocity. Finally, we found that obese humans had stiffer arteries and lower serum LOX levels than do normal-weight humans. Conclusion-Our results demonstrated that obesity resulted in aortic stiffening in both humans and mice, and established a causal relationship between LOX downregulation and aortic stiffening in obesity.

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“…58) Recently, the "Compliance index" derived from the digital volume pulse waveform was proposed; however, it showed lower values in patients with risk factors. 59) Although measurement of the digital volume pulse wave is easy, portable and useful for epidemiology studies, further investigation is needed for validation of various indices, such as its relationship with central aortic stiffness and predictability of cardiovascular risk.…”

Section: Digital Volume Pulse Wave Analysismentioning

confidence: 99%

Measurements of Arterial Stiffness: Methodological Aspects

2008

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A significant association between increased arterial stiffness and the development of cardiovascular disease has led to the increased use of arterial stiffness in the clinical assessment of cardiovascular risk. Various methods are currently available. With advances in technology, the assessment methods have become easy to use and more acceptable to patients. However, the different techniques that are available measure arterial stiffness at different locations and have unique indices for arterial stiffness. For the appropriate assessment of arterial stiffness, accurate and reproducible measurements of arterial stiffness are essential. Here we review the methodological aspects of the measurement of arterial stiffness and provide information on the measurement methods available and their clinical applications.

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Novel Compliance Index derived from digital volume pulse associated with risk factors and exercise capacity in patients undergoing treadmill exercise tests

Abstract: The Compliance Index was lower in patients with risk factors and was associated with poor exercise capacity. This index may be clinically useful for evaluating arterial stiffness.

Cited by 17 publications

References 22 publications

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity

Measurements of Arterial Stiffness: Methodological Aspects

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