Novel collagen‐based hydrogels with injectable, self‐healing, wound‐healing properties via a dynamic crosslinking interaction

Abstract

Collagen‐based hydrogels have gained significant popularity in biomedical applications; however, traditional collagen hydrogels are easily disabled for lack of self‐healing properties due to their non‐reversible bonds. Here, a self‐healing collagen‐based hydrogel has been developed based on dynamic network chemistry, consisting of dynamic imine linkages between collagen and dialdehyde guar gum, as well as diol‐borate ester bonds between guar gum and borax. In addition, macromolecular interactions amongst macromolecules are involved. The above‐mentioned interactions were validated by Fourier transform infrared spectroscopy, sodium dodecyl sulfate polyacrylamide gel electrophoresis and DSC. The as‐prepared collagen‐based hydrogels showed good injectability and rapid self‐healing capacity (within 3 min) as reflected from injection tests, optical microscope observations, rheological measurements, as well as self‐healing studies. In addition, the collagen‐based hydrogels showed accelerated wound‐healing properties. This study offers a facile strategy to endow self‐healing ability on collagen‐based hydrogels without any external stimulus, which show great application potential as wound dressings. © 2020 Society of Chemical Industry

Dynamic protein and polypeptide hydrogels based on Schiff base co-assembly for biomedicine

“…161 Of all collagen types, Type I Collagen is most widely used to design hybrid scaffolds for bone grafting, 162 tissue regeneration, 163 and cardiac healing, 164 owing to its good hydrophilicity, low antigenicity, and high biocompatibility. A series of self-healing, injectable collagen hydrogels for repairing dermal wounds have been built by Ding et al 165 These composite hydrogels consisted of two dynamic covalent networks: one based on imine linkages between collagen and dialdehyde guar gum, and the other based on diol-borate ester bonds between guar gum and borax. Guar gum is a natural polysaccharide consisting of linear chains of 1,4 linked β- d -mannose bonded to α-galactose by 1,6 glycosidic linkages in a molar ratio 1 : 2.…”

“…167 Cellulose nanocrystals (CNCs), derived from cellulose via acidic hydrolysis, feature ease of surface modification and good mechanical resistance but may turn out to be cytotoxic when appended to gels using non-biocompatible sources or 2) (Adapted with permission. 165 Copyright 2020, Society of Chemical Industry.) methods.…”

“…(2) (a) In vivo wound closure in mice by self-healing of dual-network collagen-CGG hydrogels, (b) wound closure percentage over time, (c) hydrogel injection on mouse skin. (2) (Adapted with permission 165. Copyright 2020, Society of Chemical Industry.…”

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

“…The pH-responsive hydrogel was fabricated from the cPEG polymer with 1,3-benzene diboronic acid at alkaline conditions through boronic ester bonds formations [75]. The diol borate ester bond between the borate ions with the -OH groups of guar gum in the collagen-based hydrogel for wound dressing material was investigated systematically [76].…”

A ternary biocomposite based on modified fish scale collagen and ginsenoside Rb1: preparation, properties and bioactivities

“…Studies of the use of fish collagen for the preparation of hemostatic agents have been limited. Fish collagen has high absorption ability, biocompatibility, no religious hindrances and involves no infectious diseases 11, 12 . Moreover, the collagen extracted from fish scales or skin scales contributes to the reduction of environmental pollution from fish processing wastes.…”