Novel chitosan - graphene quantum dots composite for therapeutic delivery and tracking through enzymatic stimuli response

Kumara, B.N.; Shambhu, Rashmi; Prabhu, Ashwini; Prasad, K. Sudhakara

doi:10.1016/j.carbpol.2022.119426

Cited by 16 publications

(14 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, the peaks found at 1632 cm −1 , 1537 cm −1 , and 1368 cm −1 are associated with ester carbonyl and –OH bending groups of the LP. 15 The remaining peaks are associated with the CS and pHEMA material as explained above. In the LP-TM nanocomposite-loaded CL (LP-TM-CL), the peaks were observed at 3333 cm −1 and 3251 cm −1 similar to the LP nanocomposite due to the occurrence of –OH and –NH moieties.…”

Section: Resultsmentioning

confidence: 99%

“…We recently demonstrated a novel-CS-graphene quantum dot (GQD)-loaded nanocomposite, which delivers LP in the presence of Lyz. 15 In the present work, we have attempted to incorporate the GQD-CS drug loaded nanocomposite into the CL matrix by the pre-load technique. The fabrication was performed by simple free radical co-polymerization in the presence of pHEMA and co-initiators under UV light (365 nm).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A promising ‘single’ and ‘dual’ drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme

Kumara,

Velmurugan,

Ghate

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A promising ‘single’ and ‘dual’ drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme

Kumara,

Velmurugan,

Ghate

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Kumara et al encaged GQD‐chitosan nanocomposite into the drug, latanoprost used in the treatment of glaucoma and demonstrated the delivery of the drug triggered by the enzyme lysozyme. The biocompatibility, intercellular tracking, and protection of corneal epithelial cells from H 2 O 2 ‐induced injury by the delivered drug were also reported (Kumara et al, 2022). Kiani Nejad et al prepared a nanoplatform by conjugating MnFe 2 O 4 , SiO 2 , and GQDs to improve the effect of the anticancer drug daunorubicin and a pH‐dependent drug release.…”

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 85%

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

View full text Add to dashboard Cite

The carbon‐based nanostructures have led to the development of theranostic nanoplatforms for simultaneous diagnosis and therapy due to their effective cell membrane‐penetration ability, low degree of cytotoxicity, excellent pore volume, substantial chemical stability, and reactive surface. In the last few years, extensive efforts were made to design multifunctional nanoplatform strategies based on carbon nanostructures, involving multimodal imaging, controlled drug release capabilities, sensing in vitro, efficient drug loading capacity, and therapy. Carbon and graphene quantum dots (CQDs and GQDs) were the recent entrants, contingently being assessed for drug delivery and bioimaging. With the advancements, these quantum dots have ignited remarkable research interest and are now widely evaluated for diagnosis, bioimaging, sensing, and drug delivery applications. The last decade has witnessed their remarkable electrical, optical, and biocompatible properties since their inception. It is presumed that both of them have high potential as drug carriers and would serve as the next generation of approaches to address numerous unresolved therapeutic challenges. This review examined the recent advances of CQD and GQD based drug delivery applications, challenges, and future perspectives to pave the way for further studies in the future.

show abstract

“…GQDs decorated hollow mesoporous CuS nanoparticles system triggered DOX release through NIR laser [243] and GQDs decorated porous silicon (pSi) system released drug by H 2 O 2 -responsive oxidation [244]. Kumara et al also proposed CS-GQDs system releasing the anti-glaucoma drug latanoprost through lysozyme-stimulated response [245]. Through these diverse release strategies, successful GQDs based drug delivery has been achieved.…”

Section: Super-resolution Imagingmentioning

confidence: 99%

A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)

Bae,

Cho,

Hong

2024

Nanotechnology

View full text Add to dashboard Cite

A new type of 0-dimensional carbon-based materials called graphene quantum dots (GQDs) is gaining significant attention as a non-toxic and eco-friendly nanomaterial. GQDs are nanomaterials composed of sp2 hybridized carbon domains and functional groups, with their lateral size less than 10 nm. The unique and exceptional physical, chemical, and optical properties arising from the combination of graphene structure and quantum confinement effect due to their nano-size make GQDs more intriguing than other nanomaterials. Particularly, the low toxicity and high solubility derived from the carbon core and abundant edge functional groups offer significant advantages for the application of GQDs in the biomedical field. In this review, we summarize various synthetic methods for preparing GQDs and important factors influencing the physical, chemical, optical, and biological properties of GQDs. Furthermore, the recent application of GQDs in the biomedical field, including biosensor, bioimaging, drug delivery, and therapeutics are discussed. Through this, we provide a brief insight on the tremendous potential of GQDs in biomedical applications and the challenges that need to be overcome in the future.

show abstract

Novel chitosan - graphene quantum dots composite for therapeutic delivery and tracking through enzymatic stimuli response

Cited by 16 publications

References 48 publications

A promising ‘single’ and ‘dual’ drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme

A promising ‘single’ and ‘dual’ drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

A review on synthesis, properties, and biomedical applications of graphene quantum dots (GQDs)

Contact Info

Product

Resources

About