A promising ‘single’ and ‘dual’ drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme

Kumara, B. N.; Velmurugan, K.; Ghate, M. Vivek; Shambhu, R.; Nirmal, Jayabalan; Prasad, K. Sudhakara

doi:10.1039/d3tb02624h

Cited by 3 publications

(1 citation statement)

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“…Glaucoma patients can benefit from both the controlled application of medications to the eye and the accurate tracking of IOP through SCLs. Kumara et al (2024) developed a contact lens for glaucoma management that can deliver a single drug (latanoprost) or two drugs simultaneously (latanoprost and timolol) to the ocular surface [72]. Their design relies on a chitosan-based nanocomposite material which entraps the drug product and is hydrolyzed in the presence of naturally occurring lysozyme in tear.…”

Section: Glaucomamentioning

confidence: 99%

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Wu,

Dave,

Carbonneau

et al. 2024

Micromachines

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Smart contact lenses represent a breakthrough in the intersection of medical science and innovative technology, offering transformative potential in ophthalmology. This review article delves into the technological underpinnings of smart contact lenses, emphasizing the current landscape and advancements in biosensors, power supply, biomaterials, and the transmission of ocular information. This review further applies new innovations to their emerging role in the diagnosis, monitoring, and management of various ocular conditions. Moreover, we explore the impact of technical innovations on the application of smart contact lenses in monitoring glaucoma, managing postoperative care, and dry eye syndrome, further elucidating the non-invasive nature of these devices in continuous ocular health monitoring. The therapeutic potential of smart contact lenses such as treatment through targeted drug delivery and the monitoring of inflammatory biomarkers is also highlighted. Despite promising advancements, the implementation of smart contact lenses faces technical, regulatory, and patient compliance challenges. This review synthesizes the recent advances to provide an outlook on the state of smart contact lens technology. Furthermore, we discuss future directions, focusing on potential technological enhancements and new applications within ophthalmology.

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Section: Glaucomamentioning

confidence: 99%

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Wu,

Dave,

Carbonneau

et al. 2024

Micromachines

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Insights into ocular therapeutics: A comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery

Chandel,

Kandav

2024

Journal of Drug Delivery Science and Technology

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Lysozyme activated co-delivery of latanoprost–timolol from mucoadhesive chitosan nanocomposite to manage glaucoma

Kumara,

Shambhu,

Shim

et al. 2024

RSC Pharm.

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A promising ‘single’ and ‘dual’ drug-nanocomposite enriched contact lens for the management of glaucoma in response to the tear fluid enzyme

Abstract: Glaucoma is a neurodegenerative condition that results in the damage of retinal ganglion cells due to elevated intraocular pressure (IOP). To curtail the limitations with conventional treatments such as eye...

Cited by 3 publications

References 60 publications

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Insights into ocular therapeutics: A comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery

Lysozyme activated co-delivery of latanoprost–timolol from mucoadhesive chitosan nanocomposite to manage glaucoma

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