Novel chemotherapeutic and renal protective effects for the green tea (EGCG): Role of oxidative stress and inflammatory-cytokine signaling

El‐Mowafy, Abdalla M.; Al‐Gayyar, Mohammed M.H.; Salem, Hatem A.; El-Mesery, Mohamed; Darweish, M.M.

doi:10.1016/j.phymed.2010.08.004

Cited by 57 publications

(42 citation statements)

References 43 publications

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“…42 The association between antioxidant and antiinflammatory activities of EGCG and its protective role against CP-induced nephrotoxicity has been shown by El-Mowafy and coworkers in mice bearing Ehrlich ascites carcinoma (EAC). 43 This study showed that EGCG administered in combination with CP [ Serum urea and creatinine. Y GSH.…”

Section: Nephrotoxicitymentioning

confidence: 98%

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

et al. 2013

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s u m m a r yBackground & aims: Green tea catechins, especially epigallocatechin-3-gallate (EGCG), have been associated with cancer prevention and treatment. This has resulted in an increased number of studies evaluating the effects derived from the use of this compound in combination with chemo/radiotherapy. This review aims at compiling latest literature on this subject. Methods: Keywords including EGCG, cancer, chemotherapy, radiotherapy and side effects, were searched using PubMed and ScienceDirect databases to identify, analyze, and summarize the research literature on this topic. Most of the studies on this subject up to date are preclinical. Relevance of the findings, impact factor, and date of publication were critical parameters for the studies to be included in the review. Results: Additive and synergistic effects of EGCG when combined with conventional cancer therapies have been proposed, and its anti-inflammatory and antioxidant activities have been related to amelioration of cancer therapy side effects. However, antagonistic interactions with certain anticancer drugs might limit its clinical use. Conclusions: The use of EGCG could enhance the effect of conventional cancer therapies through additive or synergistic effects as well as through amelioration of deleterious side effects. Further research, especially at the clinical level, is needed to ascertain the potential role of EGCG as adjuvant in cancer therapy.

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Section: Nephrotoxicitymentioning

confidence: 98%

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

et al. 2013

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“…EGCG was shown to attenuate AGEs-induced RAGE expression in human kidney (Liang et al 2010) and human neuroblastoma cells (Lee and Lee 2007), decrease oxidative stress and serum creatinine in a mouse model of immune-mediated glomerulonephritis (Peng et al 2011), and reduce chemotherapyinduced TNF-α up-regulation and oxidant stress signals in mouse kidneys (El-Mowafy et al 2010). Oxygen free radicals are important mediators in the pathogenesis of arthritis as they increase proinfl ammatory cytokine expression.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate combined with alpha lipoic acid attenuates high glucose-induced receptor for advanced glycation end products (RAGE) expression in human embryonic kidney cells

Leu¹,

Lin²,

Jian³

et al. 2013

An. Acad. Bras. Ciênc.

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The anti-oxidant effects of epigallocatechin gallate (EGCG) and alpha lipoic acid (ALA) have been demonstrated in previous studies. The kidney protection effects of EGCG and ALA in patients with kidney injury are still under investigation. The purpose of this study is to investigate the anti-infl ammatory and anti-oxidant effects of EGCG and ALA on high glucose-induced human kidney cell damage. EGCG inhibited high glucose(HG)-induced TNF-α and IL-6 production in human embryonic kidney (HEK) cells. Both EGCG and ALA decreased HG-induced receptor of advanced glycation end products (RAGE) mRNA and protein expressions in HEK cells. EGCG and ALA also recovered HG-inhibited superoxide dismutase production and decreased ROS expressions in HEK cells. The synergism of EGCG and ALA was also studied. The effect of EGCG combined with ALA is greater than the effect of EGCG alone in all anti-infl ammation and anti-oxidant experiments. Our studies provide a potential therapeutic application of EGCG and ALA in preventing progression of diabetic nephropathy.

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“…As previously described, cisplatin-induced nephrotoxicity is associated with increased oxidative stress, inflammatory cytokines, and finally result in apoptosis. Several studies have shown that EGCG attenuated the CP-induced apoptosis in animal models and may represent new promising adjunct candidate for cisplatin [41][42][43][44] . The details of EGCG regulate the CP-induced apoptosis is complex and involves multiple mechanisms.…”

Section: Other Related Nephropathymentioning

confidence: 99%

The Green Tea Polyphenol(—)-epigallocatechin-3-gallate and its beneficial roles in chronic kidney disease

Bao

Peng

2016

Journal of Translational Internal Medicine

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Chronic kidney disease (CKD), a condition that affects around 10% of the population, has become a significant public health concern. Current therapeutic strategies to slow down the progression of CKD remain limited. Thus, it is urgent to develop new strategies to manage the patients with CKD. Work within the past decade has improved our understanding of the mechanisms contributing to CKD. In particular, oxidative stress as well as inflammation appears to play a pivotal role in CKD progression. (-)-Epigallocatechin-3-gallate (EGCG), the major catechin of green tea extract, is known as a powerful antioxidant and reactive oxygen species scavenger. Various studies have shown EGCG has a potential role in chronic kidney disease models. It is suggested that EGCG modulates cellular and molecular mechanisms via inflammation-related NF-κB and Nrf2 signaling pathway, as well as apoptosis-related ER stress pathway and mitochondrial pathway. Therefore, based on these studies, this review attempts to present a recent state of our knowledge and understanding of mechanisms of its role on the process of CKD, with the aim of providing some clues for the future optimization of EGCG in renal diseases.

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Novel chemotherapeutic and renal protective effects for the green tea (EGCG): Role of oxidative stress and inflammatory-cytokine signaling

Cited by 57 publications

References 43 publications

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

Epigallocatechin-3-gallate combined with alpha lipoic acid attenuates high glucose-induced receptor for advanced glycation end products (RAGE) expression in human embryonic kidney cells

The Green Tea Polyphenol(—)-epigallocatechin-3-gallate and its beneficial roles in chronic kidney disease

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