Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

Lecumberri, Elena; Dupertuis, Y.M.; Miralbell, Raymond; Pichard, Claude

doi:10.1016/j.clnu.2013.03.008

Cited by 214 publications

(148 citation statements)

References 48 publications

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“…As for hormone-related cancers, such as breast and prostate cancer, EGCG interacted with the hormone receptors, delayed the development of hormone refractory tumors, and induced chemosensitization of breast and prostate cancer in vitro and in vivo (39,40). Also, EGCG could act as a protective agent against the side effects of chemotherapy, such as gastrointestinal disorders, declination of hematological parameters and immune system, development of secondary tumors, nephrotoxicity, cardiotoxicity, ototoxicity, and dysfunction of salivary glands and pulmonary fibrosis (12).…”

Section: Discussionmentioning

confidence: 97%

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EGCG Enhances the Efficacy of Cisplatin by Downregulating hsa-miR-98-5p in NSCLC A549 Cells

Zhou

Wang

Feng

2014

Nutrition and Cancer

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In the current study, the enhanced efficacy of cisplatin caused by (-)-epigallocatechin-3-gallate (EGCG) in nonsmall cell lung cancer (NSCLC) A549 cells was observed. The tumor size was significantly smaller in vivo in the combination of cisplatin and EGCG group, as compared with cisplatin-only group. However, in NCI-H460 cells, another kind of NSCLC cells, the efficacy of cisplatin was antagonized by EGCG. MiRNA microarray showed that hsa-miR-98-5p and hsa-miR-125a-3p were differentially expressed after EGCG treatment in these 2 cell lines. After transfection of hsa-miR-98-5p inhibitor, the survival fraction of both A549 and NCI-H460 cells was decreased upon cisplatin treatment. Meanwhile, as a critical regulator in the cisplatin-induced apoptosis, p53 was elevated by silencing of hsa-miR-98-5p. These results suggested that EGCG inhibited the expression of hsa-miR-98-5p, followed by an increase of p53, thus the efficacy of cisplatin was enhanced. Bioinformatics analysis showed that hsa-miR-125a-3p might have a strong connection with classical MAPK pathway. Taken together, these findings indicate that hsa-miR-98-5p could be a potential target in clinical cisplatin treatment of NSCLC. The combination of EGCG and cisplatin might be an effective therapeutic strategy in treating some type of NSCLC, although the possibility of antagonistic interactions must also be taken into account.

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Section: Discussionmentioning

confidence: 97%

“…It has shown anticancer effect (including prostate, head and neck, and lung cancer) in many in vitro and in vivo studies (8)(9)(10). In addition to the antitumor activity of EGCG itself, it is reported that EGCG could enhance the efficacy of several chemotherapy drugs, as well as antagonize their toxicity (11,12).…”

Section: Introductionmentioning

confidence: 99%

EGCG Enhances the Efficacy of Cisplatin by Downregulating hsa-miR-98-5p in NSCLC A549 Cells

Zhou

Wang

Feng

2014

Nutrition and Cancer

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“…Green tea is made from fresh tea leaves ( Camellia sinensis ). Tea is the most widely consumed beverage next to water and provides a source of the well-known polyphenols, which are associated with a reduction in cancer risk (1). After steaming or pan-frying, enzymes are inactivated to prevent the oxidation of tea polyphenols, which are also called catechins.…”

Section: Introductionmentioning

confidence: 99%

Effects of Physiological Levels of the Green Tea Extract Epigallocatechin-3-Gallate on Breast Cancer Cells

2014

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Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 cells that was associated with down-regulation of the ERα and reduced insulin-like growth factor binding protein-2 abundance and increased protein abundance of the tumor suppressor genes p53/p21. In contrast to MCF7 cells that have wt p53, EGCG alone did not change cell proliferation or death significantly in another ERα-positive cell line T47D that possesses mutant p53. EGCG increased ERα protein levels and as a consequence, the cells responded significantly better to an ERα antagonist tamoxifen (TAM) in the presence of EGCG. EGCG significantly increased cell death in an ERα-negative cell line, MDA-MB-231 that also possesses mutant p53. EGCG significantly increased the ERα and insulin-like growth factor-I receptor levels and thereby enhanced the sensitivities of the cells to TAM and a blocking antibody targeting the insulin-like growth factor-1 receptor (αIR3). In contrast to MCF7,T47D and MDA-MB-231 breast cancer cells that exhibited significant changes in key molecules involved in breast growth and survival upon treatment with physiological levels of EGCG, the growth, survival, and levels of these proteins in non-malignant breast epithelial cells, MCF10A cells, were not affected.

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“…These compounds have shown anti-oxidative, anti-inflammatory and anticarcinogenic activities [117][118][119]. There is evidence that increased antioxidant status lowers oxidative damage to DNA, thus enhancing protection against cancer [117,120]. In addition, epidemiological data have indicated a lower incidence of cancer in subjects with higher intake of green tea [121][122][123].…”

Section: Green Tea and Coffeementioning

confidence: 99%

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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Abstract:Chronic kidney disease (CKD) affects worldwide 8-16% of the population. In developed countries, the most important risk factors for CKD are diabetes, hypertension and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced nutrition and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and help to manage and curb the main risk factors for renal damage. While the concepts of protein and salt restriction in nephrology are historically acknowledged, the role of some nutrients on renal health and the importance of nutrition as a preventative measure for renal care are less known.In this review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals and xenobiotics on renal health and function. The effects on kidney of fibres, proteins, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol, both direct and indirect, in CKD and non-CKD condition, are reviewed here. In a view of a functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions and CKD are related to systemic dysfunctions such as chronic low-grade inflammation.

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Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

Cited by 214 publications

References 48 publications

EGCG Enhances the Efficacy of Cisplatin by Downregulating hsa-miR-98-5p in NSCLC A549 Cells

EGCG Enhances the Efficacy of Cisplatin by Downregulating hsa-miR-98-5p in NSCLC A549 Cells

Effects of Physiological Levels of the Green Tea Extract Epigallocatechin-3-Gallate on Breast Cancer Cells

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

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