Novel CD-MOF NIR-II fluorophores for gastric ulcer imaging

Liu, Yishen; Yuzhen, Yuzhen; Tian, Tian; Wang, Wumei; Nong, Jinxia; Qiao, Xue; Xu, Fuchun; Gao, Jianfeng; Hong, Xuechuan

doi:10.1016/j.cclet.2021.03.075

Cited by 29 publications

(17 citation statements)

References 53 publications

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“…Consisting of electron donor group (D) and electron acceptor group (A), the D–A–D (donor–acceptor–donor) structure of CH1055 offers one of the most effective scaffolds for NIR-II organic small molecules. Since then, a series of NIR-II organic fluorophores have been considerably developed. − …”

Section: Construction and Properties Of Inorganic/organic Nir-iia/iib...mentioning

confidence: 99%

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

et al. 2021

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In vivo imaging in the second near-infrared window (NIR-II, 1000−1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types of inorganic/organic fluorophores that can be used for noninvasive NIR-IIa/IIb imaging (NIR-IIa, 1300−1400 nm; NIR-IIb, 1500−1700 nm) with near-zero tissue autofluorescence and deeper tissue penetration. This review provides an overview of the reports published to date on the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. First, we summarize the design concepts of the up-to-date functional NIR-IIa/IIb biomaterials, in the order of single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earthdoped nanoparticles (RENPs), and organic fluorophores (OFs). Then, these novel imaging modalities and versatile biomedical applications brought by these superior fluorescent properties are reviewed. Finally, challenges and perspectives for future clinical translation, aiming at boosting the clinical application progress of NIR-IIa and NIR-IIb imaging technology are highlighted.

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Section: Construction and Properties Of Inorganic/organic Nir-iia/iib...mentioning

confidence: 99%

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

et al. 2021

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“…Recently, these materials have also been explored for their properties in in catalysis, selective synthesis, mechanical energy harvesting, microwave absorption, light emission, in vivo imaging and lithium-ion batteries. 92,104,121,146,161,168,172,240 Such novel advancements underline the potential of CD-MOFs and also the future scope of applications that could emerge.…”

Section: Summary and Perspectivementioning

confidence: 99%

Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

et al. 2022

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“…[54a] Cyclodextrin metal-organic frameworks was also reported to endow CH1055 with high photostability in long radiation and low pH for gastric ulcer dynamic NIR-II imaging. [56] Liang and co-workers encapsulated the NIR-II probe FE with amphiphilic block polymer (PS-g-PEG), of which the PS backbone formed a hydrophobic core mimicking the toluene environment to effectively prevent the aggregation and fluorescence quenching of small organic dyes. The high QY (≈16.5%, Ref: QY IR26 = ≈0.5%) of the obtained probe provided enough brightness for in vivo 3D structure of blood vessels in the hindlimbs and tumor of mice, avoiding the information superposition or coverage caused by projecting 3D structure information onto a 2D plane.…”

Section: Dad Dye-based Probementioning

confidence: 99%

Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

Wang

Wan

et al. 2021

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Optical imaging in the second near infrared region (NIR‐II, 1000–1700 nm) provides higher resolution and deeper penetration depth for accurate and real‐time vascular anatomy, blood dynamics, and function information, effectively contributing to the early diagnosis and curative effect assessment of vascular anomalies. Currently, NIR‐II optical imaging demonstrates encouraging results including long‐term monitoring of vascular injury and regeneration, real‐time feedback of blood perfusion, tracking of lymphatic metastases, and imaging‐guided surgery. This review summarizes the latest progresses of NIR‐II optical imaging for angiography including fluorescence imaging, photoacoustic (PA) imaging, and optical coherence tomography (OCT). The development of current NIR‐II fluorescence, PA, and OCT probes (i.e., single‐walled carbon nanotubes, quantum dots, rare earth doped nanoparticles, noble metal‐based nanostructures, organic dye‐based probes, and semiconductor polymer nanoparticles), highlighting probe optimization regarding high brightness, longwave emission, and biocompatibility through chemical modification or nanotechnology, is first introduced. The application of NIR‐II probes in angiography based on the classification of peripheral vascular, cerebrovascular, tumor vessel, and cardiovascular, is then reviewed. Major challenges and opportunities in the NIR‐II optical imaging for vascular imaging are finally discussed.

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Novel CD-MOF NIR-II fluorophores for gastric ulcer imaging

Cited by 29 publications

References 53 publications

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

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