Novel cascade reaction-based fluorescent cyanine chemosensor for cysteine detection and bioimaging in living system

Niu, Linqiang; Luo, Yang; Gan, Ying; Cao, Qijuan; Zhu, Chao; Wang, Muxi; Wang, Jiamin; Zhang, Weihong; Wang, Jianhong

doi:10.1016/j.talanta.2020.121291

Cited by 11 publications

(1 citation statement)

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“…除直接修饰现有的识别基团外, 通过改变取代基数目、种类与位置调控识别位点电子密度或空间位阻, 也可以实现对半胱氨酸的高选择性检测. 2020 年, 王建红等 [38] 基于 Cy.7-Cl 设计合成了一系列具有单氯取代的苯甲酸酯结构作为备选识别基团的半胱氨酸荧光探针, 并辅以乙二醇单甲醚修饰吲哚鎓离子提高探针的水溶性. 当半胱氨酸取代氯原子后, 具有邻位取代的荧光探针 4 更容易发生分子内成环反应使识别基团离去, 从而表现出选择性检测线粒体内半胱氨酸的能力.…”

Section: 线粒体靶向型半胱氨酸荧光探针unclassified

Research Progress of Fluorescent Probes for Cysteine Targeting Cellular Organelles

Liu¹,

Jing²

2023

Chinese Journal of Organic Chemistry

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As an important endogenous biothiol, cysteine is involved in various physiological processes. Besides, cysteine also plays an important role in the regulation of intracellular redox levels and the synthesis of bioactive substances. Cellular organelles all act an essential role in the life process, but different cellular organelles have their own unique functions, which makes the mechanism of cysteine in different organelles may be different. The high sensitivity and in situ analyze ability of fluorescent probes provide a method to monitor cysteine in different organelles, which is helpful to understand the mechanism of cysteine in physiological process more comprehensively. In this review, the recent reports on cysteine specific fluorescent probes are classified according to their targeted organelles. Besides, the property of those probes, including their structure, response mechanism, spectral properties and biological applications, is summarized.

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Section: 线粒体靶向型半胱氨酸荧光探针unclassified