Novel caffeic acid grafted chitosan-sodium alginate microcapsules generated by microfluidic technique for the encapsulation of bioactive peptides from silkworm pupae

Xun, Xiao-Meng; Zhang, Zhi-Ang; Yuan, Zi-Xuan; Tuhong, Kamila; Yan, Cheng-Hai; Zhan, Yu-Fan; Kang, Guo-Ping; Wu, Qiongying; Wang, Jun

doi:10.1016/j.scp.2023.100974

Cited by 9 publications

(6 citation statements)

References 39 publications

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“…Over the last few years, many attempts have been made to develop synthetic methods for CS-based particles, such as ionic gelation [ 44 , 45 , 46 ], polyelectrolyte complexation [ 47 , 48 , 49 ], emulsion solvent diffusion [ 50 , 51 ], emulsion crosslinking [ 52 , 53 ], spray drying [ 54 , 55 ], supercritical fluid drying [ 56 ], electrospraying [ 57 ], emulsion droplet coalescence [ 58 ], reverse micellar/emulsion methods [ 59 , 60 ] and sieving methods [ 61 ].…”

Section: Preparation Methods For Chitosan-based Network and Particula...mentioning

confidence: 99%

“…Rod-or irregular-shaped microparticles [61]. Microcapsule [47,110,111]; multilayer particle [81,112,113]; microfiber [114]. Microcapsule [47,110,111]; multilayer particle [81,112,113]; microfiber [114].…”

Section: Irregular Particlementioning

confidence: 99%

“…olvent displacement/interfacial deposition method Sub-microcapsule nanoemulsion coated with CS shell. Microcapsule [47,110,111]; multilayer particle [81,112,113]; microfiber [114].…”

Section: Irregular Particlementioning

confidence: 99%

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Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release

2023

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The state of the art in the use of chitosan (CS) for preparing particulate carriers for drug delivery applications is reviewed. After evidencing the scientific and commercial potentials of CS, the links between targeted controlled activity, the preparation process and the kinetics of release are detailed, focusing on two types of particulate carriers: matrix particles and capsules. More precisely, the relationship between the size/structure of CS-based particles as multifunctional delivery systems and drug release kinetics (models) is emphasized. The preparation method and conditions greatly influence particle structure and size, which affect release properties. Various techniques available for characterizing particle structural properties and size distribution are reviewed. CS particulate carriers with different structures can achieve various release patterns, including zero-order, multi-pulsed, and pulse-triggered. Mathematical models have an unavoidable role in understanding release mechanisms and their interrelationships. Moreover, models help identify the key structural characteristics, thus saving experimental time. Furthermore, by investigating the close relation between preparation process parameters and particulate structural characteristics as well as their effect on release properties, a novel “on-demand” strategy for the design of drug delivery devices may be developed. This reverse strategy involves designing the production process and the related particles’ structure based on the targeted release pattern.

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Section: Preparation Methods For Chitosan-based Network and Particula...mentioning

confidence: 99%

Section: Irregular Particlementioning

confidence: 99%

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Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release

2023

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“…Xun et al successfully utilized flow-focused microchannel chips and ionic gelatinization technology to obtain capsules with silkworm pupae bioactive peptides. The CA-g-Ch-sodium alginate formula presented excellent resistivity to simulated digestion conditions [ 107 ].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Membrane-Active Peptides and Their Potential Biomedical Application

Gostaviceanu,

Gavrilaş,

Copolovici

et al. 2023

Pharmaceutics

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Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications. This review paper provides an overview of the fundamental aspects of MAPs, focusing on their membrane interaction mechanisms and potential applications. MAPs exhibit various structural features, including amphipathic structures and specific amino acid residues, enabling selective interaction with multiple membranes. Their mechanisms of action involve disrupting lipid bilayers through different pathways, depending on peptide properties and membrane composition. The therapeutic potential of MAPs is significant. They have demonstrated antimicrobial activity against bacteria and fungi, making them promising alternatives to conventional antibiotics. MAPs can selectively target cancer cells and induce apoptosis, opening new avenues in cancer therapeutics. Additionally, MAPs serve as drug delivery vectors, facilitating the transport of therapeutic cargoes across cell membranes. They represent a fascinating class of biomolecules with significant potential in basic research and clinical applications. Understanding their mechanisms of action and designing peptides with enhanced selectivity and efficacy will further expand their utility in diverse fields. Exploring MAPs holds promise for developing novel therapeutic strategies against infections, cancer, and drug delivery challenges.

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“…They achieved encapsulation rates ranging from 74% to 82%, demonstrating favorable encapsulation efficacy. The preparation of sodium alginate microcapsules commonly involves methods such as spray drying, extrusion, emulsion gelation, and layer assembly [ 16 ]. Among these, the sharp pore method is considered the simplest approach for producing sodium alginate microcapsules with uniform particle size [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and Characterization of Proanthocyanidin Microcapsules by Sodium Alginate and Carboxymethyl Cellulose

Li,

Zhang,

Zhao

et al. 2024

Foods

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Proanthocyanidins are important compounds known for their antioxidant and radical scavenging properties, but they are highly sensitive to light, heat, oxygen, and pH. In our study, proanthocyanidin was encapsulated using sodium alginate and carboxymethyl cellulose to enhance controlled release, pH stability, metal ion tolerance, temperature resistance, time release, the microencapsulation of food additives stability, antioxidant capacity analysis, and the storage period tolerance of proanthocyanidin. Fourier transforms infrared (FTIR) analysis and full-wavelength UV scanning indicated the successful immobilization of proanthocyanidins into the polymeric microcapsules. The flowability and mechanical properties of the microcapsules were enhanced. Moreover, proanthocyanidin microcapsules exhibited higher thermal, pH, metal ion, time, and microencapsulation food additive stability. In addition, due to their high antioxidant properties, the proanthocyanidin microcapsules retained a greater amount of proanthocyanidin content during the gastric phase, and the proanthocyanidin was subsequently released in the intestinal phase for absorption. Thus, the study provided a systematic understanding of the antioxidant capabilities and stability of proanthocyanidin microcapsules, which is beneficial for developing preservation methods for food additives.

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Novel caffeic acid grafted chitosan-sodium alginate microcapsules generated by microfluidic technique for the encapsulation of bioactive peptides from silkworm pupae

Cited by 9 publications

References 39 publications

Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release

Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release

Membrane-Active Peptides and Their Potential Biomedical Application

Encapsulation and Characterization of Proanthocyanidin Microcapsules by Sodium Alginate and Carboxymethyl Cellulose

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