Novel Brønsted acidic deep eutectic solvent as reaction media for esterification of carboxylic acid with alcohols

Santi, Valerio De; Cardellini, Fabio; Brinchi, Lucia; Germani, Raimondo

doi:10.1016/j.tetlet.2012.07.063

Cited by 97 publications

(69 citation statements)

References 22 publications

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“…Thus, aliphatic and aromatic carboxylic acids were heated (60-80 ºC) in the mixture TCyAMsO-p-TsOH (1:1) during 2-17 h producing the corresponding esters with yields ranging from 16 to 97%. [53] Based on the same idea, a mixture of urea and ZnCl2 (4:1 molar ratio) was active as catalytic medium in the glycolysis of poly(ethyleneterephthalate) by transesterification with ethylene glycol. [54] Scheme 6.…”

Section: Esterification-type Reactionsmentioning

confidence: 99%

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

et al. 2016

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This microreview summarizes the use of deep eutectic solvents (DES) and related melts in Organic Synthesis. This type of solvents combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high availability, low inflammability, high recyclability, low volatility and low price, avoiding many disadvantages of these neoteric media. The fact that many of the components of the mixture come directly from Nature assures their biodegradability and renewability. The classification and distribution of the reactions in different sections along this microreview, as well as the emphasis paid to their scope, easily allows a general reader to understand the actual state of art, and the great opportunities opened, not only for academic proposes but also for industry.

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Section: Esterification-type Reactionsmentioning

confidence: 99%

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

et al. 2016

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“…Fig. 8 Quaternary ammonium salts used for DES preparation (De Santi et al 2012) and the structure of ions constituting deep eutectic solvents studied (Hayyan et al 2013a, b, c) Another example of studies on the toxicity of eutectic solvents are tests conducted on an aquatic invertebrate-Hydra sinensis. Those organisms are highly vulnerable to chemical pollution.…”

Section: Toxicity Of Deep Eutectic Solventsmentioning

confidence: 99%

Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review

Kudłak

Owczarek

Namieśnik

2015

Environ Sci Pollut Res

292

133

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Green Chemistry plays a more and more important role in implementing rules of sustainable development to prevent environmental pollution caused by technological processes, while simultaneously increasing the production yield. Ionic liquids (ILs) and deep eutectic solvents (DESs) constitute a very broad group of substances. Apart from many imperfections, ILs and DESs have been the most promising discoveries in the world of Green Chemistry in recent years. The main advantage of ILs is their unique physicochemical properties-they are very desirable from the technological point of view, but apart from these benefits, ILs appear to be highly toxic towards organisms from different trophic levels. DES areas of usage are very spread, because they cover organic synthesis, extraction processes, electrochemistry, enzymatic reactions and many others. Moreover, DESs seem to be a less toxic alternative to ionic liquids. New possibilities of applications and future development trends are sought and presented, including such important solutions of life branches as pharmaceuticals' production and medicine.

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“…Indeed, homogeneous acid catalysts such as para-toluenesulfonic, sulphuric hydrofluoric and heteropoly acids are often used in industrial processes for this purpose (Liljaa et al, 2002;Jaques and Leisten, 1964;Sejidova et al, 1990;Santia et al, 2012;Gonçalves et al, 2012;Pappu et al, 2013). Nevertheless, these corrosive acid catalysts are difficult to be removed from the reaction medium (Farnetti et al, 2004).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%