Novel boronated chlorin e6-based photosensitizers: Synthesis, binding to albumin and antitumour efficacy

Ionic Liquid-Based Chlorins and Type III Mechanism of Photodynamic Therapy (PDT)

“…[244][245][246][247] Therefore antioxidant supplementation is of interest to prevent or ameliorate those diseases. [248][249][250][251] Pd(OAc) 2 So far, several transition metal complexes of MPa, for example, palladium(II), 252,253 zinc(II), [254][255][256] copper(II), 254,256-259 nickel(II), 254,256,260 iron(II), 261 manganese(III), 262,263 and tin(IV) 252 have been synthesized and characterized. The Ol'shevskaya group reported 253 the low dark cytotoxicity of the palladium(II) and tin(IV) complexes of MPa.…”

Protonation-deprotonation equilibria in tetrapyrroles Part 3: Mono- and diprotonations of the trimethyl esters of chlorin e6 and the 71-acetal of rhodin g7 in methanolic hydrochloric acid

“…1) and of the acetal (3) of its 7 1 -oxo derivative (2) in the methanolic hydrochloric acid system, which was used earlier in the acid-base studies of phytyl/methyl pyropheophorbide a (8,9) [35,42] and subsequently in the studies of b-substituted dicarboxylic porphyrin dimethyl esters (P.H. Hynninen, Protonation-deprotonation in tetrapyrroles.…”

“…These reactions enabled the functionalization of ring B and led to the discovery of partial synthetic routes to bacteriochlorin derivatives and to Chl b (5). Further, it is noteworthy that chlorin e 6 and its derivatives have been extensively investigated as effective photosensitizers for photodynamic therapy (PDT) [6][7][8][9][10][11][12][13][14][15][16][17][18]. Recently, the molecular structure of chlorin e 6 TME was determined by X-ray crystallography [19].…”

Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo

“…[11][12][13][14] They are often selected because of their high singlet oxygen quantum yields and spectroscopic properties 15 : Characteristic absorption spectra with a Soret band at approximately 415 nm and a usually narrow but very strong Q-band around 650 nm, with a molar absorption coe±cient in the range of 10 5 M À1 cm À1 . Temopor¯n and mesotetahydroxyphenylchlorin have been used for esophageal cancer, head and neck cancer, early gastric cancer and gastrointestinal cancer super¯cial portion.…”