Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo

Abstract

In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm 2 , 1.2 to 3.6 J/cm 2 Þ and destroy Eca-109 tumor in nude mice (50 mW/cm 2 , 90 J/cm 2 Þ. It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation.

Editorial

“…2 Both have a characteristic absorption peak at about 650 nm and were found to be e®ective both in vitro and in vivo. Complementing this research paper, a review article is contributed by Li et al to introduce the photophysics, photochemistry, photobiology, and chemical and biological syntheses of perylenequinonoid pigment Elsinochrome A and the future prospects for EA are also brie°y discussed.…”