Novel biomaterial based on monoamine oxidase-A and multi-walled carbon nanotubes for serotonin detection

Becerra-Hernández, A.; Galindo‐de‐la‐Rosa, J.; Martínez-Pimentel, Y.; Ledesma‐García, J.; Álvarez‐Contreras, Lorena; Guerra‒Balcázar, Minerva; Aguilar-Elguézabal, A.; Álvarez, A.; Chávez-Ramírez, A.U.; Vallejo-Becerra, Vanessa

doi:10.1016/j.bej.2019.107240

Cited by 10 publications

(3 citation statements)

References 41 publications

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“…Purified MAO is not stable enough for most applications, but MAO electrodes incorporating membrane-bound MAO have been devised for measurement of amines, for example, for serotonin using MAO A [86,87]. For electrode use, an alternative to oxygen as the electron acceptor in the oxidative half-reaction is desirable.…”

Section: Is There Potential For Applied Use Of Mao?mentioning

confidence: 99%

Questions in the Chemical Enzymology of MAO

Ramsay

Albreht

2021

Chemistry

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We have structure, a wealth of kinetic data, thousands of chemical ligands and clinical information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have comparative information from various species and mutations on kinetics and effects of inhibition. Nevertheless, there are what seem like simple questions still to be answered. This article presents a brief summary of existing experimental evidence the background and poses questions that remain intriguing for chemists and biochemists researching the chemical enzymology of and drug design for monoamine oxidases (FAD-containing EC 4.1.3.4).

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Section: Is There Potential For Applied Use Of Mao?mentioning

confidence: 99%

Questions in the Chemical Enzymology of MAO

Ramsay

Albreht

2021

Chemistry

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“…Other studies have used enzyme immobilization for detection of biomarkers, like serotonin, to be detected by monoamine oxidase-A enzyme immobilized on multi-walled carbon nanotubes (MWCNT). [38] The size and shape of the electrodes is also an important variable, and in general, small electrodes are preferred to reduce the system size. An important consideration in regard to the geometry is the detection method.…”

Section: Working Electrodesmentioning

confidence: 99%

Design of Electrochemical Microfluidic Detectors: A Review

Díaz-Real

Holm

2021

Adv Materials Technologies

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Miniaturized electrochemical systems integrated into microfluidic flow devices have been an active research field the last couple of decades. This has resulted in many advanced microfluidic platforms for the conversion and detection of chemicals. The development is partly driven by the increased access to and decreased cost of fabrication. In the design of microfluidic electrochemical cells, several aspects need to be handled, such as the accurate control of potential, electrolyte flow, pH, pressure, and temperature. This can be further complicated by integrating photon traffic for spectro(electro)chemical detection. Here, a comprehensive review of recent advances and approaches to the design of microfluidic flow devices for detection is presented, first dealing with the design of electrodes and flow pathways, then highlighting some common challenges and how these have been dealt with in the literature. This work aims to be a guide for researchers in the design of microfluidic electrochemical systems for detection of chemical species.

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“…In a similar study for the enzyme-based quantification of serotonin, a monoamine neurotransmitter associated with memory and happiness, a GCE was functionalised with MWCNT with monoamine oxidase A (MAO-A) immobilisation. The potentiometric detection of serotonin in a concentration range of 5.67 × 10 −7 –2.26 × 10 −6 M was achieved in simulated body fluid with a high sensitivity (LOD: 2 × 10 −7 M) [94].…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

159

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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Novel biomaterial based on monoamine oxidase-A and multi-walled carbon nanotubes for serotonin detection

Cited by 10 publications

References 41 publications

Questions in the Chemical Enzymology of MAO

Questions in the Chemical Enzymology of MAO

Design of Electrochemical Microfluidic Detectors: A Review

Nanomaterials for Healthcare Biosensing Applications

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