Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension

Sahni, Mitali; Yeboah, Bettie; Das, Pragnya; Shah, Dilip; Ponnalagu, Devasena; Singh, Harpreet; Nelin, Leif D.; Bhandari, Vineet

doi:10.1038/s41372-020-00788-8

Cited by 32 publications

(16 citation statements)

References 30 publications

(19 reference statements)

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“…These changes will affect the flow of tissue fluid, aggravate the inflammatory response, and lead to edema, suggesting that lower extremity edema may also be related to increased Ang-2 expression and could be the reason why lower extremity edema and Ang-2 are independent risk factors for DVT. Sahni et al (35) also reported that the serum level of Ang-2 is positively correlated with inflammatory mediators such as TNF-α and interleukin 6, and these two inflammatory factors have been proved to be risk factors for DVT in many studies. As a pro-inflammatory factor, Ang-2 plays an important role in the physiological activities of promoting inflammation and vascular leakage (32).…”

Section: Discussionmentioning

confidence: 98%

Construction and validation of risk prediction model for deep vein thrombosis in acute exacerbations of chronic obstructive pulmonary disease based on serum angiopoietin 2 levels

He¹,

Sun²,

Zhang³

et al. 2021

Ann Palliat Med

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Background: This study aims to establish a predictive risk model for deep vein thrombosis (DVT) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) based on serum angiopoietin 2 (Ang-2) levels.Methods: The research sample consisted of 650 patients with AECOPD admitted to the First Affiliated Hospital of Chengdu Medical College from January 2019 to January 2021, who were subsequently divided into a modeling group and a verification group. A univariate analysis was performed on the identified risk factors for DVT in AECOPD, and the significant factors were then incorporated into a multivariate logistic regression model to screen for the independent predictors of DVT. A nomogram was constructed, and a receiver operating characteristic curve (ROC), Hosmer-Lemeshow test, decision curve, and clinical impact curve in the modeling and validation cohort were used to analyze the discrimination power, calibration, and clinical validity of the predictive risk nomogram model of AECOPD with comorbid DVT.Results: Univariate and multivariate logistic regression analyses showed that lower limb edema, BMI, diabetes, respiratory failure, D-dimer, and serum Ang-2 were risk factors for DVT in AECOPD. A nomogram model for predicting AECOPD with comorbid DVT was successfully established. The AUC values for the modeling group and the verification group were 0.844 (95% CI: 0.808-0.932) and 0.755 (95% CI: 0.679-0.861), respectively. According to the Hosmer-Lemeshow test, the P values of the nomogram in the modeling group and the verification group were 0.124 and 0.086, respectively. The decision curve and clinical impact curve suggested that most patients can benefit from this prediction model, and the predicted probability of the model was essentially the same as the actual clinical probability of DVT. Conclusions:The predictive risk nomogram model of AECOPD with comorbid DVT based on serum Ang-2 levels has good discrimination power, calibration, and clinical influence. The model is a good fit and has a high predictive value, which helps clinicians identify AECOPD patients at high risk of DTV and formulate corresponding prevention and treatment measures.

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Section: Discussionmentioning

confidence: 98%

Construction and validation of risk prediction model for deep vein thrombosis in acute exacerbations of chronic obstructive pulmonary disease based on serum angiopoietin 2 levels

He¹,

Sun²,

Zhang³

et al. 2021

Ann Palliat Med

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“…In recent years, scientific and technical developments in neonatology have led to a survival rate of <10% to >80% for low birth weight premature infants in developed countries; however, this development has led to the appearance of more morbidities [9][10][11]. The pathogenesis of BPD is multifactorial, oxygen toxicity, barotrauma, volutrauma, and even biotrauma, where IL-1β, IL-6, and IL-8 play a part in the aetiology [12,13]. It is accepted that the frequency increases as the gestational age and the birth weight decrease and the risk, especially at preterms born less than 30 weeks of gestation, is reported to be higher [14,15].…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

Akcan

Oygucu

Arslan

et al. 2022

BioMed Research International

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Background. Bronchopulmonary dysplasia (BPD) carries a risk of long-term pulmonary sequelae. High-resolution computed tomography (HRCT) is a method of detecting such structural changes. This study is aimed at characterizing structural abnormalities associated with BPD and at evaluating the clinical findings in the newborn period associated with HRCT scores. Methods. 28 patients born with a mean gestation age of 30 ± 2.9 weeks and diagnosed as BPD in their neonatal period were reevaluated when they were between the postnatal ages of 6 and 12 months. HRCT was performed in 20 patients with a history of moderate and severe BPD. Scans were interpreted by one radiologist using a scoring system. Results. Patients were 9.8 ± 2.3 months at the time of reevaluation. The average HRCT score of patients was, respectively, 7.20 ± 4.05 with moderate and 7.40 ± 2.84 with severe BPD. The difference between them was not significant ( p = 0.620 ). When moderate and severe groups were collected as a whole on the basis of physical findings and drug treatment, 6 had normal physical examination findings, no oxygen and no drug requirement; 14 had at least one finding at the time of reevaluation. No significant difference was detected in terms of HRCT score between the two groups ( 6.50 ± 3.83 versus 7.64 ± 3.30 ). Conclusions. More studies are needed in terms of the role of HRCT in the assessment of BPD prognosis. A contemporary definition of BPD that correlates with respiratory morbidity in childhood is needed. Also, a new lung ultrasound technique for predicting the respiratory outcome in patients with BPD can be used instead of HRCT.

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“…In this context, research on biomarkers is of high relevance to improve the diagnostic options in early detection of aberrant organ development. Candidates have been studied in clinical situations of known organ damage, e.g., BDP (294,295) and neonatal kidney injury (296)(297)(298) and will have to be tested in the context of metabolic programming. Importantly, the goal is not to label an individual organ function as pathological beyond classical criteria but to identify individuals who are at risk to develop disease later in life in order to provide targeted prevention strategies.…”

Section: Systemic Consequences Of Fetal Programmingmentioning

confidence: 99%

Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases

et al. 2021

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Lung development is not completed at birth, but expands beyond infancy, rendering the lung highly susceptible to injury. Exposure to various influences during a critical window of organ growth can interfere with the finely-tuned process of development and induce pathological processes with aberrant alveolarization and long-term structural and functional sequelae. This concept of developmental origins of chronic disease has been coined as perinatal programming. Some adverse perinatal factors, including prematurity along with respiratory support, are well-recognized to induce bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease that is characterized by arrest of alveolar and microvascular formation as well as lung matrix remodeling. While the pathogenesis of various experimental models focus on oxygen toxicity, mechanical ventilation and inflammation, the role of nutrition before and after birth remain poorly investigated. There is accumulating clinical and experimental evidence that intrauterine growth restriction (IUGR) as a consequence of limited nutritive supply due to placental insufficiency or maternal malnutrition is a major risk factor for BPD and impaired lung function later in life. In contrast, a surplus of nutrition with perinatal maternal obesity, accelerated postnatal weight gain and early childhood obesity is associated with wheezing and adverse clinical course of chronic lung diseases, such as asthma. While the link between perinatal nutrition and lung health has been described, the underlying mechanisms remain poorly understood. There are initial data showing that inflammatory and nutrient sensing processes are involved in programming of alveolarization, pulmonary angiogenesis, and composition of extracellular matrix. Here, we provide a comprehensive overview of the current knowledge regarding the impact of perinatal metabolism and nutrition on the lung and beyond the cardiopulmonary system as well as possible mechanisms determining the individual susceptibility to CLD early in life. We aim to emphasize the importance of unraveling the mechanisms of perinatal metabolic programming to develop novel preventive and therapeutic avenues.

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Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension

Cited by 32 publications

References 30 publications

Construction and validation of risk prediction model for deep vein thrombosis in acute exacerbations of chronic obstructive pulmonary disease based on serum angiopoietin 2 levels

Construction and validation of risk prediction model for deep vein thrombosis in acute exacerbations of chronic obstructive pulmonary disease based on serum angiopoietin 2 levels

High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases

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