High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

Abstract

Background. Bronchopulmonary dysplasia (BPD) carries a risk of long-term pulmonary sequelae. High-resolution computed tomography (HRCT) is a method of detecting such structural changes. This study is aimed at characterizing structural abnormalities associated with BPD and at evaluating the clinical findings in the newborn period associated with HRCT scores. Methods. 28 patients born with a mean gestation age of 30 ± 2.9 weeks and diagnosed as BPD in their neonatal period were reevaluated when they were between the postnatal ages of 6 and 12 months. HRCT was performed in 20 patients with a history of moderate and severe BPD. Scans were interpreted by one radiologist using a scoring system. Results. Patients were 9.8 ± 2.3 months at the time of reevaluation. The average HRCT score of patients was, respectively, 7.20 ± 4.05 with moderate and 7.40 ± 2.84 with severe BPD. The difference between them was not significant ( p = 0.620 ). When moderate and severe groups were collected as a whole on the basis of physical findings and drug treatment, 6 had normal physical examination findings, no oxygen and no drug requirement; 14 had at least one finding at the time of reevaluation. No significant difference was detected in terms of HRCT score between the two groups ( 6.50 ± 3.83 versus 7.64 ± 3.30 ). Conclusions. More studies are needed in terms of the role of HRCT in the assessment of BPD prognosis. A contemporary definition of BPD that correlates with respiratory morbidity in childhood is needed. Also, a new lung ultrasound technique for predicting the respiratory outcome in patients with BPD can be used instead of HRCT.

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

“…The HRCT score was more strongly correlated (r=0.646, p<0.001) with the clinical severity of BPD than the CXR score. In contrast, another study found no significant difference in the mean HRCT scores of moderate and severe BPD [ 118 ]. Moreover, CT scoring systems were directly associated with a variety of adverse physiological and clinical outcomes in neonates with BPD, such as the duration of oxygen exposure, incidence of desaturation events during sleep, severity of wheezing and rate of decline in forced expiratory volume in 1 s [ 119 , 120 ].…”

Relação entre polimorfismos genéticos e displasia broncopulmonar: uma revisão narrativa

“…A displasia broncopulmonar possui uma patogênese multifatorial, onde a toxicidade do oxigênio, barotrauma, volutrauma e biotrauma podem estar envolvidos. Sabe-se que a idade gestacional e o peso ao nascer são inversamente proporcionais à frequência de neonatos com DBP e a participação de interleucinas (IL-1β, IL-6 e IL-8) e outros mediadores inflamatórios na etiologia da DBP também é relatada na literatura (Akcan et al, 2022).…”