Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T

McCann, Conor; Glover, Ben; Menown, Ian; Moore, Michael J.; McEneny, Jane; Owens, Colum; Smith, Bernie; Sharpe, Peter; Young, Ian S.; Adgey, Jennifer

doi:10.1093/eurheartj/ehn363

Cited by 200 publications

(122 citation statements)

References 16 publications

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“…The interfering species tested were proteins that coexist with Myo in serum and their concentrations were selected according to their relative levels in biological fluids [40][41][42][43]. Cardiac biomarkers such as TnT and CKMB and a protein present in a biological fluids BSA were selected.…”

Section: Selectivitymentioning

confidence: 99%

Electrochemical biosensor based on biomimetic material for myoglobin detection

Moreira

Dutra

Noronha

et al. 2013

Electrochimica Acta

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a b s t r a c tA novel reusable molecularly imprinted polymer (MIP) assembled on a polymeric layer of carboxylated poly(vinyl chloride) (PVC COOH) for myoglobin (Myo) detection was developed. This polymer was casted on the gold working area of a screen printed electrode (Au-SPE), creating a novel disposable device relying on plastic antibodies. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and Fourier transform infrared spectroscopy (FTIR) studies confirmed the surface modification.The MIP/Au-SPE devices displayed a linear behaviour in EIS from 0.852 to 4.26 g mL −1 , of positive slope 6.50 ± 1.48 (k mL g −1 ). The limit of detection was 2.25 g mL −1 . Square wave voltammetric (SWV) assays were made in parallel and showed linear responses between 1.1 and 2.98 g mL −1 . A current decrease was observed against Myo concentration, producing average slopes of −0.28 ± 0.038 A mL g −1 . MIP/Au-SPE also showed good results in terms of selectivity. The error% found for each interfering species were 7% for troponin T (TnT), 11% for bovine serum albumin (BSA) and 2% for creatine kinase MB (CKMB), respectively. Overall, the technical modification over the Au-SPE was found a suitable approach for screening Myo in biological fluids.

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Section: Selectivitymentioning

confidence: 99%

Electrochemical biosensor based on biomimetic material for myoglobin detection

Moreira

Dutra

Noronha

et al. 2013

Electrochimica Acta

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“…10,11 h-FABP has proven to be an early marker for the detection of myocardial infarction (MI), better than myoglobin and troponin for very early detection. [11][12][13][14][15] It also could be a sensitive marker for minor myocardial injury in patients with unstable angina (UA). 11,16,17 A novel qualitative test for the detection of h-FABP has recently been developed.…”

mentioning

confidence: 99%

Clinical Assessment of Ischemia‐modified Albumin and Heart Fatty Acid–binding Protein in the Early Diagnosis of Non‐ST‐elevation Acute Coronary Syndrome in the Emergency Department

Charpentier

Ducassé

Cournot

et al. 2010

Academic Emergency Medicine

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Objectives: Heart fatty acid-binding protein (h-FABP) and ischemia-modified albumin (IMA) have recently been evaluated, but to the best of our knowledge, no study has reported an analysis of these two markers for the detection of early myocardial infarction and myocardial ischemia in a large cohort of consecutive patients presenting to an emergency department (ED). This study evaluates the diagnostic accuracy and the clinical utility of h-FABP and IMA for non-ST-segment elevation acute coronary syndrome (ACS) diagnosis in the first hour of management in an ED.Methods: In a prospective 11-month study, 677 patients admitted to the ED with chest pain and suspected non-ST-segment elevation ACS were enrolled. On presentation, blood samples were obtained for the measurement of the biomarkers h-FABP (immunodetection with CardioDetect) and IMA (albumin cobalt-binding test). Two physicians, blinded to the results of the markers, independently categorized patients as having or not having non-ST-segment elevation ACS.Results: Of the 677 patients who were prospectively recruited, non-ST-segment elevation ACS was diagnosed in 185 (27.3%). While IMA was not predictive of the ACS diagnosis (odds ratio [OR] = 1.23; 95% CI = 0.87 to 1.81), h-FABP was predictive of ACS diagnosis (OR = 4.65; 95% CI = 2.39 to 9.04) with specificity at 96.8% (95% CI = 95.4% to 98.1%) and sensitivity at 13.5% (95% CI = 10.9% to 16.1%). However, h-FABP did not add significant additional information to a predictive model that included the usual diagnostic tools for non-ST-elevation ACS management (p = 0.40). Conclusions:In this study on a large cohort of patients admitted to an ED for chest pain, IMA and h-FABP did not provide valuable information for ACS diagnosis.

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“…A study of 346 patients who presented to the ED with chest pain found that PAPP-A levels were significantly higher in those patients who were diagnosed with AMI (175). In a second study that included 415 patients admitted to a cardiology unit with suspected ACS, PAPP-A levels were also found to be significantly higher in those patients with AMI although the AUC was only 0.56, suggesting that PAPP-A is unlikely to be useful as a lone diagnostic investigation for AMI (176). Further, a case control study found no significant difference in PAPP-A levels between 80 patients with STEMI and 80 healthy controls (177).…”

Section: Pregnancy-associated Plasma Protein a (Papp-a)mentioning

confidence: 98%

Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective

Body¹,

Slevin²,

McDowell³

2012

Traditional and Novel Risk Factors in Atherothrombosis

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Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T

Abstract: Assessment of H-FABP within the first 4 h of symptoms is superior to cTnT for detection of MI, and is a useful additional biomarker for patients with acute chest pain.

Cited by 200 publications

References 16 publications

Electrochemical biosensor based on biomimetic material for myoglobin detection

Electrochemical biosensor based on biomimetic material for myoglobin detection

Clinical Assessment of Ischemia‐modified Albumin and Heart Fatty Acid–binding Protein in the Early Diagnosis of Non‐ST‐elevation Acute Coronary Syndrome in the Emergency Department

Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective

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