Novel biocompatible zinc-curcumin loaded coaxial nanofibers for bone tissue engineering application

Sedghi, Roya; Sayyari, Nastaran; Shaabani, Alireza; Niknejad, Hassan; Tayebi, Tahereh

doi:10.1016/j.polymer.2018.03.045

Cited by 65 publications

(33 citation statements)

References 46 publications

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“…+ groups of chitosan could be identified at 1550 cm −1 , as a shoulder [26,27]. TGA (a,b) and DSC (c) profiles of all the scaffolds, compared to pristine HNT and MMT is reported in Figure 5.…”

Section: Samplementioning

confidence: 97%

Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing

et al. 2020

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The increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3–5% in the over 65 years population, with 3–5.5% of the total healthcare expenditure, as recently estimated. The aim of this work was the design and the development of electrospun scaffolds, entirely based on biopolymers, loaded with montmorillonite (MMT) or halloysite (HNT) and intended for skin reparation and regeneration, as a 3D substrate mimicking the dermal ECM. The scaffolds were manufactured by means of electrospinning and were characterized for their chemico-physical and preclinical properties. The scaffolds proved to possess the capability to enhance fibroblast cells attachment and proliferation with negligible proinflammatory activity. The capability to facilitate the cell adhesion is probably due to their unique 3D structure which are assisting cell homing and would facilitate wound healing in vivo.

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Section: Samplementioning

confidence: 97%

Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing

et al. 2020

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“…Better wound healing potential [17][18][19][20] Curcumin with gum tragacanth/poly(ε-caprolactone) nanofibers Improved antibacterial implementation and diabetic wound healing (in vivo) [21] Curcumin with almond gum/ polyvinyl alcohol (PVA) composite nanofibers Improved bioavailability and therapeutic potential [22] Zinc-curcumin with coaxial nanofibers As bone substitute [23] Curcumin with zein fibers Improved antibacterial potential [24] Curcumin with cellulose acetate/polyvinylpyrrolidone nanofibers, Curcumin with polyurethanes nanofibers, and Curcumin with gelatin nanofibers…”

Section: About Curcumin Based Nanofibers Biomedical Applications Refementioning

confidence: 99%

Electrospinning process parameters optimization for biofunctional curcumin/gelatin nanofibers

Kanu

Gupta

Vates

et al. 2020

Mater. Res. Express

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Electrospinning has received wide attention for the preparation of uniform diameter nanofibers (ranging from 5 nm to several hundred nanometers) in films with random as well as aligned fashions of the fibers of various materials for use in biomedical applications. Electrospinning research has provided an in-depth understanding of the preparation of light weight, ultrathin, porous, biofunctional curcumin/gelatin nanofibers having applications in wound dressing, drug release, tissue engineering, etc. In the first half of this article, prior research on electrospun curcumin/gelatin nanofibers is reviewed in depth with nanofibers being desired due to their low diameters since these would have then large surface area to volume ratio and enough film porosity as well as improved mechanical (tensile) strength so that when prepared as mats these nanofibers (having high biocompatibility) could be used for sustained release of curcumin and oxygen to wounds during healing. The synthesis of ultrathin nanofibers (having minimum average diameter) is not a simple task unless numerical investigation is carefully done in the first half of this research article. The authors research described here examined the effects of critical process parameters (in the second half of the paper) such as distance between the spinneret and collector, flow rate, voltage and solution viscosity, on the preparation of uniform and ultrathin nanofibers using scanning electron microscopy (SEM) for characterization of the nanofibers. A 2 k factorial design of experiment was found to be a suitable and efficient technique to optimize the critical process parameters used in the preparation of the biofunctional nanofibers with the purpose of having applications in the treatment of problematic wounds such as diabetic chronic ulcers. After parametric investigation, the distance, flow rate and voltage when taken together, were found to have the most significant contributions to the preparation of minimum diameter nanofibers. The primary objective of this research was fulfilled with the development of ultrathin curcumin/gelatin nanofibers having a 181 nm (181±66 nm) average diameter using the optimized setting of a solution having 1.5% gelatin, and 1% curcumin in 10 ml of 98% concentrated formic acid, with the electrospining unit having a voltage of 10 KV, distance from the spinneret to collector drum of 15 cm, flow rate of 0.1 ml h −1 , viscosity of 65 cP and drum collector speed of 1000 rpm. However, the lowest average diameter of nanofiber was measured around 147 nm (147±34 nm) which was prepared at a higher voltage, such as 15 KV (at 10 cm distance, 0.15 ml h −1 flow rate and 65 cP viscosity) using the solution. The design of this research paper is based on the view that merely optimization of biofunctional nanofibers may not fully satisfy researchers/ engineers unless they are also provided with sufficient information about (a) the entire electrospinning mechanism (numerical investigations of the mechanism) to have better control over preparation of ultr...

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“…More recently, Sedghi et al developed biocompatible zinc/curcumin‐loaded coaxial nanofibers for bone tissue engineering application . They showed that the curcumin‐containing scaffolds are cytocompatible and can promote osteogenesis in vitro .…”

Section: Curcumin In Te Strategiesmentioning

confidence: 99%

Curcumin in tissue engineering: A traditional remedy for modern medicine

et al. 2018

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Curcumin is the principal polyphenolic compound present in turmeric with broad applications in tissue engineering and regenerative medicine. It has some important inherent properties with the potential to facilitate tissue healing, including anti‐inflammatory, anti‐oxidant, and antibacterial activities. Therefore, curcumin has been used for the treatment of various damaged tissues, especially wound injuries. There are different forms of curcumin, among which nano‐formulations are of a great importance in regenerative medicine. It is also important to design sophisticated delivery systems for controlled/localized delivery of curcumin to the target tissues and organs. Although there are many reports on the advantages of this compound, further research is required to fully explore its clinical usage. The review describes the physicochemical and biological properties of curcumin and the current state of the evidence on its applications in tissue engineering. © 2018 BioFactors, 45(2):135–151, 2019

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Novel biocompatible zinc-curcumin loaded coaxial nanofibers for bone tissue engineering application

Cited by 65 publications

References 46 publications

Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing

Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing

Electrospinning process parameters optimization for biofunctional curcumin/gelatin nanofibers

Curcumin in tissue engineering: A traditional remedy for modern medicine

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