Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid

Śmiga-Matuszowicz, Monika; Janicki, Bartosz; Jaszcz, Katarzyna; Łukaszczyk, Jan; Kaczmarek, Marcin; Lesiak, Marta; Sieroń, Aleksander; Simka, Wojciech; Mierzwiński, Maciej; Kusz, Damian

doi:10.1016/j.msec.2014.08.069

Cited by 19 publications

(13 citation statements)

References 40 publications

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“…[40] Micropores in the size range of 1-20 lm might promote the adhesion, spreading, and proliferation of osteoblasts. [42] Those small pores help in the adsorption of bone-inducing protein as well as facile diffusion of nutrients and other components of physiological fluids, ion exchange, and bone formation. [42] Bignon et al [14] reported that microporosity (0.3 to 2 lm) promotes the cytoplasmic extension to enhance the cell spreading.…”

Section: B Microstructure Of the Sgg/peek Coatingsmentioning

confidence: 99%

“…[42] Those small pores help in the adsorption of bone-inducing protein as well as facile diffusion of nutrients and other components of physiological fluids, ion exchange, and bone formation. [42] Bignon et al [14] reported that microporosity (0.3 to 2 lm) promotes the cytoplasmic extension to enhance the cell spreading. They also found that both macroporosity and macrointerconnectivity sizes influenced the penetration of cells.…”

Section: B Microstructure Of the Sgg/peek Coatingsmentioning

confidence: 99%

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Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Moskalewicz

Zych

Łukaszczyk

et al. 2017

Metall Mater Trans A

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In this study, microporous composite sol-gel glass/polyetheretherketone (SGG/PEEK) coatings were produced on the Ti-13Nb-13Zr titanium alloy by electrophoretic deposition. Coatings with different levels of high open porosity were developed by introducing SGG particles of varying diameters into the PEEK matrix. The microstructure of the coatings was characterized by electron microscopy and X-ray diffractometry. The coatings with 40-50 lm thickness were composed of semicrystalline SGG particles consisting of hydroxyapatite, CaSiO 3 , some Ca 2 SiO 4 , and an amorphous phase containing Ca, Si, P, and O, homogeneously embedded in a semicrystalline PEEK matrix. The size of SGG particles present in the coatings strongly influenced the formation of microcracks and their adhesion to the underlying substrate. Microscratch tests showed that the coating containing SGG particles with a diameter smaller than 45 lm and open porosity of 45 pct exhibited good adhesion to the titanium alloy substrate, much better than the coating containing particles with a diameter smaller than 85 lm and total open porosity equal to 48 pct. The corrosion resistance was investigated in Ringer's solution at a temperature of 310 K (37°C) for a pH equal to 7.4 and in deaerated solutions with the use of open-circuit potential, potentiodynamic polarization, and electrochemical impedance spectroscopy. The SGG/PEEK-coated alloy indicated better electrochemical corrosion resistance compared with the uncoated alloy.

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Section: B Microstructure Of the Sgg/peek Coatingsmentioning

confidence: 99%

Section: B Microstructure Of the Sgg/peek Coatingsmentioning

confidence: 99%

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Moskalewicz

Zych

Łukaszczyk

et al. 2017

Metall Mater Trans A

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“…ISB is a bicyclic diol composed of tetrahydrofuran rings and hydroxyl groups at carbons 2 and 5. The hydroxyl groups in ISB can be found in two distinct orientations, exo and endo , and can be easily modified according to the desired applications [40,41]. Moreover, ISB has been attracting significant interest from multiple fields because of its unique rigid bicyclic structure, nontoxicity, and its ability to improve the heat resistance and mechanical properties of polymers [38,42,43,44].…”

Section: Introductionmentioning

confidence: 99%

Effects of Isosorbide Incorporation into Flexible Polyurethane Foams: Reversible Urethane Linkages and Antioxidant Activity

Shin

Liang

Ryu³

et al. 2019

Molecules

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Isosorbide (ISB), a nontoxic bio-based bicyclic diol composed from two fuzed furans, was incorporated into the preparation of flexible polyurethane foams (FPUFs) for use as a cell opener and to impart antioxidant properties to the resulting foam. A novel method for cell opening was designed based on the anticipated reversibility of the urethane linkages formed by ISB with isocyanate. FPUFs containing various amounts of ISB (up to 5 wt%) were successfully prepared without any noticeable deterioration in the appearance and physical properties of the resulting foams. The air permeability of these resulting FPUFs was increased and this could be further improved by thermal treatment at 160 °C. The urethane units based on ISB enabled cell window opening, as anticipated, through the reversible urethane linkage. The ISB-containing FPUFs also demonstrated better antioxidant activity by impeding discoloration. Thus, ISB, a nontoxic, bio-based diol, can be a valuable raw material (or additive) for eco-friendly FPUFs without seriously compromising the physical properties of these FPUFs.

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“…In addition to common glycols, IS serves as a monomer for the synthesis of unsaturated polyester resins, which as bio‐based thermosets can replace current petroleum‐based resins in certain applications . Unsaturated derivatives of IS have also been proposed as polymerizable compounds of injectable, biodegradable or stable in physiological environment, biomaterials intended for bone surgery . The synthesis by melt or azeotropic polycondensation and properties of various IS‐based polyesters were investigated and described by many authors during several last years .…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] Unsaturated derivatives of IS have also been proposed as polymerizable compounds of injectable, biodegradable or stable in physiological environment, biomaterials intended for bone surgery. 12,13 The synthesis by melt or azeotropic polycondensation and properties of various IS-based polyesters were investigated and described by many authors during several last years. [14][15][16][17][18][19] It was proved by Catalani et al that efficient method for synthesis of ISderived polyesters is polytransesterification catalyzed by lipase B.…”

Section: Introductionmentioning

confidence: 99%

Isosorbide‐based polysebacates as polymeric components for development of in situ forming implants

Śmiga-Matuszowicz

Korytkowska‐Wałach

Nowak

2019

Polymers for Advanced Techs

Self Cite

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In situ forming implants (ISFIs) appear to be a convenient drug delivery system, alternative to conventional preformed implants and microparticles for parenteral drug delivery applications. It has been shown that they offer several advantages including easy and minimally invasive application, potential for local/site‐specific drug delivery that allows reduction of side effects associated with systemic administration of drug. A few ISFI formulations based on poly(α‐hydroxy acids), solidifying by solid phase separation, are currently commercially available. In this work, polyesters based on sebacic acid, isosorbide, and optionally 1,2‐propanediol were synthesized and characterized. Poly(isosorbide sebacate‐co‐1,2‐propylene sebacate) (PISEBPG) was chosen as an essential constituent of new ISFI formulations dedicated to controlled release of doxycycline hyclate (DOXY). Basic characteristics of new ISFI formulations were investigated. In particular, the influence of addition of a relatively hydrophobic cosolvent (triacetin, TA) to a more hydrophilic 1‐methyl‐2‐pyrrolidone (NMP) as well as the presence of calcium carbonate (CAC) on the morphology of resulted depots and DOXY release profile was evaluated. Scanning electron microscopy (SEM) analysis revealed that the presence of TA resulted in more porous morphology of the depots. DOXY has been releasing continuously from depots in vitro within 12 weeks depending on the composition. The release profile of the PISEBPG‐based formulation containing CAC indicates that it could be useful where short‐term (up to 14 d), rapid release of the antibiotic is required, while formulation without CAC, where after 21 days about 50% of the drug loaded may still be available for release, may be better for the long‐term delivery of DOXY.

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Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid

Cited by 19 publications

References 40 publications

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Effects of Isosorbide Incorporation into Flexible Polyurethane Foams: Reversible Urethane Linkages and Antioxidant Activity

Isosorbide‐based polysebacates as polymeric components for development of in situ forming implants

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