Novel Bat Coronaviruses, Brazil and Mexico

Góes, Luiz Gustavo Bentim; Ruvalcaba, Sicilene Gonzalez; Campos, Angélica Cristine de Almeida; Queiroz, Luzia Helena; Carvalho, Catherine Teixeira de; Jerez, José Antonio; Durigon, Edison Luíz; Íñiguez‐Dávalos, Luis Ignacio; Dominguez, Samuel R.

doi:10.3201/eid1910.130525

Cited by 32 publications

(32 citation statements)

References 10 publications

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“…With a focus centered on bats as reservoirs, metagenomics analyses have found varying levels of coronavirus diversity in bat populations in North America (26) and China (27,28), as well as detecting individual strains in bat populations worldwide (reviewed in 29). Novel coronaviruses continue to be discovered in bat populations globally; recent examples include samples from Mexico (30), Brazil (31), and South Africa (32). A recent estimate of viral diversity in the bat species Pteropus giganteus from Bangladesh identified 55 viruses, four of which were coronaviruses (33).…”

Section: Coronavirus Host Range Expansionmentioning

confidence: 98%

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

Peck¹,

Burch²,

Heise

et al. 2015

Annu. Rev. Virol.

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Coronaviruses have frequently expanded their host range in recent history, with two events resulting in severe disease outbreaks in human populations. Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2003 in Southeast Asia and rapidly spread around the world before it was controlled by public health intervention strategies. The 2012 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak represents another prime example of virus emergence from a zoonotic reservoir. Here, we review the current knowledge of coronavirus cross-species transmission, with particular focus on MERS-CoV. MERS-CoV is still circulating in the human population, and the mechanisms governing its cross-species transmission have been only partially elucidated, highlighting a need for further investigation. We discuss biochemical determinants mediating MERS-CoV host cell permissivity, including virus spike interactions with the MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and evolutionary mechanisms that may facilitate host range expansion, including recombination, mutator alleles, and mutational robustness. Understanding these mechanisms can help us better recognize the threat of emergence for currently circulating zoonotic strains.

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Section: Coronavirus Host Range Expansionmentioning

confidence: 98%

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

Peck¹,

Burch²,

Heise

et al. 2015

Annu. Rev. Virol.

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“…Taken together, these results represent the first detection of lineage C β-CoV in South American bats. Despite of close relationship between lineage C β-CoVs in Asia, Africa and Europe, cumulative data indicate that this lineage showed a more diversified host family distribution in Americas in Mormoopidae, Phyllostomidae and Molossidae bat species (Anthony et al, 2013;Corman et al, 2013;Goes et al, 2013).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…A limited number of studies have been conducted in Brazil to map the nature and breath of bats in harbouring viral populations. In previous studies, a total of five distinct CoV lineages have been detected in just 10% of local bats (15 species), and most of these are belonging to α-CoV (Brandao et al, 2008;Corman et al, 2013;Goes et al, 2013). These attributes, and the existence of a large number of human beings (120 million) in the Atlantic Forest Biome, Brazil, clearly highlight the potential of bats in not only carrying zoonotic viruses but also in possible transmission of viruses to human beings.…”

Section: Introductionmentioning

confidence: 97%

“…All CoVs that can potentially infect human were originated from animal reservoirs, and four of such CoVs are believe to be transmitted to human through bats including α-CoVs (229E and NL63) and highly pathogenic β-CoV (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome) (Bolles et al, 2011;Chan et al, 2015;Corman et al, 2013;Huynh et al, 2012). Recently, a number of novel bats CoVs have been identified, primarily from African, Asian and European bats (Calisher et al, 2006;Chu et al, 2006;Drexler et al, 2014), as well as from South American countries including Costa Rica, Panama, Ecuador, Mexico and Brazil (Corman et al, 2013;Goes et al, 2013). Collectively, these studies indicate the co-existence of bats and viruses at the interface of viral evolution and bats ecology.…”

Section: Introductionmentioning

confidence: 99%

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Genetic diversity of bats coronaviruses in the Atlantic Forest hotspot biome, Brazil

Góes

Campos

Carvalho

et al. 2016

Infection, Genetics and Evolution

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Bats are notorious reservoirs of genetically-diverse and high-profile pathogens, and are playing crucial roles in the emergence and re-emergence of viruses, both in human and in animals. In this report, we identified and characterized previously unknown and diverse genetic clusters of bat coronaviruses in the Atlantic Forest Biome, Brazil. These results highlight the virus richness of bats and their possible roles in the public health.

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“…Phylogenetic evidence indicates that SARS-CoV and MERS-CoV originated from bats Ge et al, 2013;Lau et al, 2013). Since the 2002-2003 outbreak of SARS in China, coronaviruses have been discovered in 71 bat species throughout Asia, America, Africa, and Europe (Tang et al, 2006;Lau et al, 2012;Woo et al, 2012b;Anthony et al, 2013;De Benedictis et al, 2013;Geldenhuys et al, 2013;Goes et al, 2013;Graham et al, 2013;Lelli et al, 2013;Shi, 2013). Among the 15 established alpha-and betacoronavirus species, eight were identified in bats in China, including Miniopterus bat coronavirus 1 (BtCoV 1), Miniopterus bat coronavirus HKU8 (BtCoV HKU8), Rhinolophus bat coronavirus HKU2 (BtCoV HKU2), Scotophilus bat coronavirus 512 (BtCoV 512), SARS-related or SARS-like CoVs (SL-CoV; WIV1, Rp3, HKU3, etc.…”

Section: Introductionmentioning

confidence: 99%

Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft

et al. 2016

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Since the 2002-2003 severe acute respiratory syndrome (SARS) outbreak prompted a search for the natural reservoir of the SARS coronavirus, numerous alpha- and betacoronaviruses have been discovered in bats around the world. Bats are likely the natural reservoir of alpha- and betacoronaviruses, and due to the rich diversity and global distribution of bats, the number of bat coronaviruses will likely increase. We conducted a surveillance of coronaviruses in bats in an abandoned mineshaft in Mojiang County, Yunnan Province, China, from 2012-2013. Six bat species were frequently detected in the cave: Rhinolophus sinicus, Rhinolophus affinis, Hipposideros pomona, Miniopterus schreibersii, Miniopterus fuliginosus, and Miniopterus fuscus. By sequencing PCR products of the coronavirus RNA-dependent RNA polymerase gene (RdRp), we found a high frequency of infection by a diverse group of coronaviruses in different bat species in the mineshaft. Sequenced partial RdRp fragments had 80%-99% nucleic acid sequence identity with well-characterized Alphacoronavirus species, including BtCoV HKU2, BtCoV HKU8, and BtCoV1, and unassigned species BtCoV HKU7 and BtCoV HKU10. Additionally, the surveillance identified two unclassified betacoronaviruses, one new strain of SARS-like coronavirus, and one potentially new betacoronavirus species. Furthermore, coronavirus co-infection was detected in all six bat species, a phenomenon that fosters recombination and promotes the emergence of novel virus strains. Our findings highlight the importance of bats as natural reservoirs of coronaviruses and the potentially zoonotic source of viral pathogens.

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Novel Bat Coronaviruses, Brazil and Mexico

Cited by 32 publications

References 10 publications

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

Genetic diversity of bats coronaviruses in the Atlantic Forest hotspot biome, Brazil

Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft

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