Novel approaches to radiotherapy-induced skin reactions: A literature review

Maddocks, Wendy; Wilkinson, Jenny M.; Shillington, David

doi:10.1016/j.ctcp.2005.02.001

Cited by 47 publications

(37 citation statements)

References 52 publications

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“…However, even with the most modern radiotherapy techniques, up to 90% of patients will experience a dose-dependent skin reaction at the treated area [1][2][3][4] . Skin reactions related to radiation therapy usually manifest within 1-4 weeks of radiation start, persist for the duration of radiation therapy, and may require 2-4 weeks to heal after completion of therapy 5 .…”

Section: Introductionmentioning

confidence: 99%

“…A survey of nursing practice in Belgium revealed that management of skin reactions varies, and traditional practices such as avoiding skin washing and using talcum powder are still advised by a significant number of nurses even though those practices are controversial in the literature 11 . The high incidence of radiation-induced skin reactions has generated interest in methods of preventing and effectively treating such reactions 1 .…”

Section: Introductionmentioning

confidence: 99%

“…The use of barrier or corticosteroid creams, Aloe vera, and other lanolinfree hydrophilic products is often recommended for this purpose 1 . A Cancer Care Ontario guideline for the prevention of skin reactions suggests skin washing with mild soap and water, but because of limited evidence, suggests no specific products for prevention or management 6 .…”

Section: Introductionmentioning

confidence: 99%

“…The objective of treatment for dry desquamation is to lessen patient discomfort by providing moisture to the affected areas 12 . Treatment of moist desquamation usually involves the use of hydrocolloid dressings to reduce exposure to external pathogens and ultimately to prevent infection 1 . Although a general consensus among radiotherapy centres is lacking, the advice given to patients has a few commonalities:…”

Section: Introductionmentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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Radiation therapy is a common treatment for cancer patients. One of the most common side effects of radiation is acute skin reaction (radiation dermatitis) that ranges from a mild rash to severe ulceration. Approximately 85% of patients treated with radiation therapy will experience a moderate-to-severe skin reaction. Acute radiation-induced skin reactions often lead to itching and pain, delays in treatment, and diminished aesthetic appearance-and subsequently to a decrease in quality of life.Surveys have demonstrated that a wide variety of topical, oral, and intravenous agents are used to prevent or to treat radiation-induced skin reactions. We conducted a literature review to identify trials that investigated products for the prophylaxis and management of acute radiation dermatitis. Thirty-nine studies met the pre-defined criteria, with thirty-three being categorized as prophylactic trials and six as management trials.For objective evaluation of skin reactions, the Radiation Therapy Oncology Group criteria and the U.S. National Cancer Institute Common Toxicity Criteria were the most commonly used tools (65% of the studies). Topical corticosteroid agents were found to significantly reduce the severity of skin reactions; however, the trials of corticosteroids evaluated various agents, and no clear indication about a preferred corticosteroid has emerged. Amifostine and oral enzymes were somewhat effective in preventing radiation-induced skin reactions in phase ii and phase iii trials respectively; further large randomized controlled trials should be undertaken to better investigate those products. Biafine cream (Ortho-McNeil Pharmaceuticals, Titusville, NJ, U.S.A.) was found not to be superior to standard regimes in the prevention of radiation-induced skin reactions (n = 6).In conclusion, the evidence is insufficient to support the use of a particular agent for the prevention and management of acute radiation-induced skin reactions. Future trials should focus on comparing agents and approaches that, in phase i and ii trials, suggest efficacy. These future phase iii randomized controlled trials must clearly distinguish between preventive and management strategies for radiation-induced dermatitis. Only then can evidence-based guidelines be developed, with the hope of standardizing the approach across centres and of improving the prevention and management of radiation-induced dermatitis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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“…Radiodermatitis or acute radiation skin reactions (ARSR) is a constant complication after radiotherapy with no efficient drug for prevention and treatment [1] [2], characterized by erythema, dry desquamation or moist desquamation. This wet desquamation is a very painful condition for the patient and often leads to interruption of radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of PTCTS Cosmetic Gel: Study on Human Radiodermatitis Lesions

Graziani¹,

Eyll²,

Fristachi³

et al. 2015

CRCM

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Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the basal layer by radiolysis, overproduction of free radicals, pro-inflammatory cytokines, and inflammation. PTCTS gel is an after sun cosmetic gel composed by antioxidative plant extract rich in natural nanoparticles and thermal water (Complex A) and recombinant protein of Trypanosoma cruzi transialidase (Complex B), with high anti-oxidative and antiapoptotic effects, presenting anti-aging and healing cutaneous properties. Objective: To study the safety and efficacy of PTCTS gel for topic use in volunteer subjects with healthy skin, and in patients with radiodermatitis, in different concentrations of Complexes A and B. Material and Methods: The project was approved by the Ethical Committee of Arnaldo Vieira de Carvalho Institute, Sao Paulo, Brazil. The individuals were submitted to laboratorial toxicity study through tests for liver and kidney function, levels of blood glucose and blood count before and after 7 days of PTCTS application. We studied two groups: GI-22 volunteers with healthy skin, presenting articular or skeletal muscle pain and GII-38 patients in radiotherapy for breast or head and neck cancer, with radiodermatitis grade 2 or 3. The patients were evaluated before and after 1.0 ml/cm 2 PTCTS gel application, twice a day. We tested Complex B in four different concentrations, and Complex A concentrations varied inversely. Results: No irritation signs were observed in GI nor GII group, 64% of GI had important decrease in the intensity of the muscular or articular pain, and 99% of GII showed regression of radiodermatitis, all exhibiting relief of pain. No patient presented hematologic, renal or hepatic toxicity. Conclusion: PTCTS cosmetic gel is a safe option for radiodermatitis treatment, with no side effects or laboratorial toxicity in different concentrations. This product presented excellent clinical results even if used diluted 4 times more than the original product and may be a good option for treatment of radiodermatitis. Further studies may show if it is also indicated in the prevention of the lesion, and if it is better than products containing corticoids. S. R. Graziani et al.328

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Rosehip (Rosa canina L.) Oil

Kıralan

2019

Fruit Oils: Chemistry and Functionality

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Novel approaches to radiotherapy-induced skin reactions: A literature review

Cited by 47 publications

References 52 publications

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Safety and Efficacy of PTCTS Cosmetic Gel: Study on Human Radiodermatitis Lesions

Rosehip (Rosa canina L.) Oil

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