Novel Approaches to Detect and Treat Biofilms within the Root Canals of Teeth: A Review

Walsh, L. J.

doi:10.3390/antibiotics9030129

Cited by 10 publications

(12 citation statements)

References 67 publications

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“…Pathogenic bacteria are highly responsible for nosocomial (hospital-borne) infections, which mainly occur due to biofilm formation on indwelling medical devices and implants such as heart valves, pacemakers, vascular grafts, catheters, prosthetic joints, intrauterine devices, sutures, and contact lenses ( Ghosh et al, 2020 ). Several biofilm driven infections include dental caries and root canal infections, bacterial vaginosis, cardiovascular disease, diabetic foot infections, and urinarytract infections along with prostatitis ( Malik et al, 2013 ; Lanter et al, 2014 ; Delcaru et al, 2016 ; Jung et al, 2017 ; Walsh, 2020 ). Interestingly, AgPtNHs exhibited higher antibiofilm activity in compared to individual AgNPs or PtNPs.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

et al. 2021

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Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100°C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of ∼59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of −14.46, −1.09, and −11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

et al. 2021

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“…The applied methodology was adopted from Ossmann et al [ 20 ]. In brief, after inoculation with E. faecalis for 48 h, the samples were dried twice for 10 s each with ISO 50 paper points (DentsplyDeTrey, Konstanz, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…In order to overcome the lack of inefficient intracanal disinfection, new chemical compounds and methods are constantly under investigation for their suitability in endodontic antiseptic treatment [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect of Endodontic Disinfections on Enterococcus Faecalis in Dental Root Canals—An In-Vitro Model Study

et al. 2021

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Enterococcus faecalis (E. faecalis) is rather unsusceptible to many root canal disinfections which often cause a therapeutic problem. Therefore, the present in vitro study observed the efficiency of different endodontic antiseptics in their capability to suppress E. faecalis, especially inside dentinal tubules. Prior to any testing, root canals of extracted third human molars were inoculated with E. faecalis for 48 h. Antiseptic dressings with chloramine-T or calcium hydroxide (CaOH) for 24 h or irrigations with 1.3% sodium hypochlorite (NaOCl) were applied with n = 10 in each group. As control irrigation with normal saline was used. All treated canals were manually enlarged from size ISO 50 to 110 and the ablated dentin debris was subjected to microbial culture analysis. Bacterial colonization of the dentinal tubules up to 300 µm was verified by scanning electron microscopy and histological sample preparation. Application of crystalline chloramine-T caused total bacterial suppression inside the dentinal tubules. Dressings with CaOH showed only minor effects. Irrigation with NaOCl caused total eradication of bacteria adhering to the root canal walls, but also failed to completely suppress E. faecalis inside the dentinal tubules. The study showed that chloramine-T is of strong antiseptic activity and also efficient in suppressing E. faecalis inside dentinal tubules.

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“…Root canal infection is an indicator of damage to the tissue, especially the nerves. 1 In general, root canal infections are influenced by pathogenic bacteria found in root canals.2 Enterococcus faecalis was reported as the leading agent as the most dominant biofilm-forming bacteria in root canal infections. These bacteria are complicated to eliminate, especially in cases of chronic infection.…”

Section: Introductionmentioning

confidence: 99%

Biomass index and viscosity values of Moringa oleifera that influenced by Enterococcus faecalis

Soraya¹,

Alibasyah²,

Gani³

2022

JDS

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Enterococcus faecalis (E. faecalis) has been reported as the primary infectious agent in rootcanals. Moringa oleifera (M. oleifera) is said to have the ability to prevent the development of E. faecalis.The purpose of this study was to measure the biomass index and viscosity of the ethanol extract ofMoringa (Moringa oleifera) leaves, which were affected by E. faecalis. This study used Moringa oleiferaand E. faecalis. The biomass index of Moringa oleifera extracts using the Biomass Assay method and theviscosity with the Ostwald Viscometer. The biomass index of M. oleifera affected by E. faecalis at aconcentration of 12.5% for 48 hours was better than other concentrations. CHX has a perfect biomassindex at 24 hours, while at 48 hours, the biomass index increases to close to 10%. Meanwhile, M. oleiferahas a high viscosity at a concentration of 12.5% (0.81 Cp). The results of the viscosity examination werein line with the biomass index with a positive correlation (0.92) and p0.05 between the M. oleiferaconcentrations between the two treatments. M. oleifera has very good biomass and viscosity index at aconcentration of 12.5%. Both are determinants of the development of E. faecalis under the influence of M.oleifera.KEYWORDS bomassa indek, viskositas, E. faecalis

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Novel Approaches to Detect and Treat Biofilms within the Root Canals of Teeth: A Review

Cited by 10 publications

References 67 publications

Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

Antibacterial Effect of Endodontic Disinfections on Enterococcus Faecalis in Dental Root Canals—An In-Vitro Model Study

Biomass index and viscosity values of Moringa oleifera that influenced by Enterococcus faecalis

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