Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

Ranpariya, Bansi; Salunke, Gayatri; Karmakar, Srinibas; Babiya, Kaushik R.; Sutar, Santosh S.; Kadoo, Narendra Y.; Kumbhakar, Pathik; Ghosh, Sougata

doi:10.3389/fmicb.2020.610968

Cited by 44 publications

(13 citation statements)

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“…Preparation of L. frutescens leaf extract (LFLE) was carried out as per our earlier report ( Ranpariya et al, 2021 ). In short, L. frutescens leaves were collected from RK.…”

Section: Methodsmentioning

confidence: 99%

“…Large scale application of nanotechnology include almost every aspect of life such as, textiles, paints, sensors, electrical equipments, agriculture, and even therapeutics (Jadoun et al, 2021). Smaller dimension and large surface area makes the nanoparticles ideal for functionalization with drugs, contrast agents and targeting ligands that is significant for biomedical applications (Aftab et al, 2018;Karmakar et al, 2021). Nanoparticles can be fabricated employing top-down and bottom-up approaches.…”

Section: Introductionmentioning

confidence: 99%

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Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation

et al. 2022

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The application of nanotechnology is gaining worldwide attention due to attractive physico-chemical and opto-electronic properties of nanoparticles that can be also employed for catalytic dye degradation. This study reports a phytogenic approach for fabrication of silver (AgNPs) and gold nanoparticles (AuNPs) using Leucophyllum frutescens (Berl.) I. M. Johnst (Scrophulariaceae) leaf extract (LFLE). Development of intense dark brown and purple color indicated the synthesis of AgNPs and AuNPs, respectively. Further characterization using UV-visible spectroscopy revealed sharp peak at 460 nm and 540 nm for AgNPs and AuNPs, respectively that were associated to their surface plasmon resonance. High resolution transmission electron microscope (HRTEM) revealed the spherical shape of the AgNPs, whereas anisotropic AuNPs were spherical, triangular and blunt ended hexagons. The majority of the spherical AgNPs and AuNPs were ∼50 ± 15 nm and ∼22 ± 20 nm, respectively. Various reaction parameters such as, metal salt concentration, temperature and concentration of the leaf extract were optimized. Maximum synthesis of AgNPs was obtained when 5 mM for AgNO3 reacted with 10% LFLE for 48 h at 50°C. Likewise, AuNPs synthesis was highest when 2 mM HAuCl4 reacted with 10% LFLE for 5 h at 30°C. Energy dispersive spectroscopy (EDS) showed phase purity of both the nanoparticles and confirmed elemental silver and gold in AgNPs and AuNPs, respectively. The average hydrodynamic particles size of AgNPs was 34.8 nm while AuNPs was 140.8 nm as revealed using dynamic light scattering (DLS) that might be due to agglomeration of smaller nanoparticles into larger clusters. ZETA potential of AgNPs and AuNPs were 0.67 mV and 5.70 mV, respectively. X-ray diffraction (XRD) analysis confirmed the crystallinity of the nanoparticles. Fourier transform infrared spectroscopy (FTIR) confirmed that various functional groups from the phytochemicals present in LFLE played a significant role in reduction and stabilization during the biogenic synthesis of the nanoparticles. The bioreduced AgNPs and AuNPs catalytically degraded Rhodamine B dye (RhB) in presence of UV-light with degradation rate constants of 0.0231 s−1 and 0.00831 s−1, respectively. RhB degradation followed a first order rate kinetics with 23.1 % and 31.7% degradation by AgNPs and AuNPs, respectively.

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“…Preparation of L. frutescens leaf extract (LFLE) was carried out as per our earlier report ( Ranpariya et al, 2021 ). In short, L. frutescens leaves were collected from RK.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation

et al. 2022

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“…The inhibitory activity of Ag–PtNPs was more efficient against all pathogens than that of individual AgNPs or PtNPs. In the antimicrobial synergy tests, the activity of rifampicin and novobiocin combined with Ag–PtNPs showed a significant result against S. aureus . The bimetallic MNP-conjugated antibiotics showed interesting antimicrobial properties and may be a promising tool for developing novel agents.…”

Section: Therapeutic Agents Conjugated With Mnps and Antimicrobial Ef...mentioning

confidence: 99%

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Ribeiro

Dias

Zille

2022

ACS Appl. Nano Mater.

111

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Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function of novel medical devices. Combining MNPs with commercial antimicrobial drugs (e. g., antibiotics, antifungals and antivirals) may offer several opportunities to overcome some disadvantages of their individual use and enhance effectiveness. MNPs-conjugates display multiple advantages. As drug delivery systems, the conjugates can extend the circulation of the drugs in the body, facilitate intercellular targeting, improve drug stabilization, and possess superior delivery. Concomitantly, they reduce the required drug dose, minimize toxicity and broaden the antimicrobial spectrum. In this work, the common strategies to combine MNPs with clinically used antimicrobial agents are underscored. Furthermore, a comprehensive survey about synergistic antimicrobial effects, mechanism of action and cytotoxicity is depicted. SilverAntimicrobial, drug deliver, anticancer, anti-angiogenic and biosensors 46,47 Gold Drug delivery, catalyst for medical therapy, antimicrobial conjugations, anticancer, gene therapy and diagnostic 48,49 Copper and copper oxide Antimicrobial and catalysis 50, 51 Iron and iron oxideAnticancer therapy, magnetic resonance imaging, targeted drug delivery and cell separation catalysis [52][53][54] Zinc oxide Personal care products, coatings, drug delivery, anticancer and antimicrobial 55, 56Aluminum oxide Drug delivery, biosensing, cancer therapy, antimicrobial, biomolecular preservation, immunotherapy 57 Titanium oxideDrug delivery, photodynamic therapy, cell imaging, biosensors, and genetic engineering, antimicrobial 58,59 Platinum Biomedical devices, anticancer therapies, cardiovascular diseases, bioimaging, nanozymes, biosensors, antimicrobial 60, 61 PalladiumPhotothermal agents, photoacoustic agents, antimicrobial, anticancer, gene/drug carriers, prodrug activators and biosensors 62,63 Scheme 1. MNPs used in biomedical applications. Silver Nanoparticles (AgNPs)AgNPs are the most prevalent inorganic nanoparticles applied as antimicrobial agent. AgNPs have demonstrated high antimicrobial activity comparable to Ag ionic form. However, several concerns have emerged regarding their cytotoxicity. The toxicity mechanisms, long-term accumulation effects and dose-response relationship are still grievously unknown. 64 Gold Nanoparticles (AuNPs)AuNPs are extremely valuable in developing antibacterial agents due to their low toxicity, high propensity for functionalization, eclectic effects, easy detection and photothermal activity. AuNPs per se possess very low antimicrobial activity, but numerous studies on the antimicrobial activity of AuNPs conjugated with small molecules, such as drugs, vaccines and antibodies, have been reported.

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“…Silver has been complexed with various other metals such as copper oxide [186], gold [187], platinum [188], etc., to produce AgNP nanohybrids with synergistic or unique properties that are superior to AgNPs alone. The nanohybrids improved the efficacy of antimicrobial agents [189] when used as carriers or in combination therapy. In an interesting study by Kazemzadeh-Narbat et al, titanium oxide nanotube implants consisting of multiple layers of thin films were synthesized and used for the time-dependent release of an AMP (HHC-36/KRWWKWWRR-NH 2 ).…”

Section: Nanohybrids For Enhanced Biocompatibility and Efficacymentioning

confidence: 99%

Nanotechnology-Based Delivery Systems for Antimicrobial Peptides

et al. 2021

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Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides (AMPs) have shown potential as alternative diagnostic and therapeutic agents in biomedical applications. To date, over 3000 AMPs have been identified, but only a fraction of these have been approved for clinical trials. Their clinical applications are limited to topical application due to their systemic toxicity, susceptibility to protease degradation, short half-life, and rapid renal clearance. To circumvent these challenges and improve AMP’s efficacy, different approaches such as peptide chemical modifications and the development of AMP delivery systems have been employed. Nanomaterials have been shown to improve the activity of antimicrobial drugs by providing support and synergistic effect against pathogenic microbes. This paper describes the role of nanotechnology in the targeted delivery of AMPs, and some of the nano-based delivery strategies for AMPs are discussed with a clear focus on metallic nanoparticle (MNP) formulations.

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Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

Cited by 44 publications

References 51 publications

Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation

Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation

Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

Nanotechnology-Based Delivery Systems for Antimicrobial Peptides

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