Novel Approaches to Cardiac Valve Repair

Yacoub, Magdi H.; Cohn, Lawrence H.

doi:10.1161/01.cir.0000115633.19829.5e

Cited by 110 publications

(32 citation statements)

References 56 publications

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“…2 analyses were used to evaluate the categorical variables, whereas the Wilcoxon 2-sample test was used to compare differences in means for continuous variables. ORs were calculated for operative mortality rates with a 95% CI.…”

Section: Methodsmentioning

confidence: 99%

“…1 Since that time, advances in technology and techniques have resulted in a significant decrease in operative mortality in direct proportion to the increasing prevalence of valve surgeries in the United States, particularly among elderly patients. [1][2][3][4] Operative mortality for both aortic valve replacement (AVR) and mitral valve replacement (MVR) has been shown to be inversely related to hospital volume. 5 An increase in operative mortality after valve replacement surgery has been observed in women, diabetics, and renal failure patients and as a function of advanced age.…”

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confidence: 99%

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Relationship Between Race and Mortality and Morbidity After Valve Replacement Surgery

et al. 2005

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Background-Previous studies have shown that black race is an independent predictor of increased operative mortality after coronary artery bypass surgery. Given the higher incidence of hypertension and hypertension-associated left ventricular hypertrophy in blacks, we hypothesized that black race might be associated with increased risk of mortality and morbidity after aortic valve replacement (AVR) or mitral valve replacement (MVR). We could not identify a previous study that used a multivariable model to evaluate the association between race and operative mortality after AVR or MVR. Methods and Results-The Society of Thoracic Surgeons National Cardiac Database was used for a retrospective review of 3137 black and 46 249 white patients who underwent MVR alone or AVR alone from 1999 through 2002. Multivariate logistic regression was used to assess the association between race and mortality and 6 other adverse outcomes (stroke, renal failure, prolonged ventilation, prolonged postoperative stay, sternal infection, and bleeding) after adjustment for covariates. Unadjusted operative mortality for MVR only was 5.60% for blacks versus 6.18% for whites (OR 0.90 [95% CI 0.71 to 1.14]) and 4.60% for blacks versus 3.62% for whites for AVR only (OR 1.28 [95% CI 1.02 to 1.62]). After adjustment for other risk factors, black race was not a significant predictor of operative mortality after AVR or MVR; however, black race was associated with an increased risk of several complications: prolonged ventilation after AVR or MVR, postoperative stay Ͼ14 days after AVR or MVR, reoperation for bleeding after AVR, and postoperative renal failure after MVR. There was no significant association between race and the risk of stroke or deep sternal wound infection for either AVR or MVR. Conclusions-In contrast to previously published results that defined race as an independent risk factor for operative mortality after coronary artery bypass surgery, race does not appear to be a significant predictor of operative mortality after isolated AVR or MVR; however, there is evidence of an association between race and certain complications.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Relationship Between Race and Mortality and Morbidity After Valve Replacement Surgery

et al. 2005

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“…The role of this "endothelium-cusp-nerve interaction" in health and disease is an interesting and yet insufficiently explained arena in the healthy and diseased aortic valve. Below the layer of endothelial cells lining the outer and inner layer of the aortic cusps (the fibrosa and ventricularis), the extracellular matrix is found, composed of elastin, collagen and proteoglycans 10 . In addition to the elastin, collagen and proteoglycans in this extracellular matrix, a population of valve interstitial cells can be found 2,3 .…”

Section: Cellular Components Of the Aortic Cuspsmentioning

confidence: 99%

Cellular and Neuronal Aspects in Aortic Stenosis

Ker¹,

Heerden²

2011

Aortic Stenosis - Etiology, Pathophysiology and Treatment

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“…The mitral orifice undergoes striking changes in its size and shape during different parts of the cardiac cycle [4]. The annulus changes its shape both in the horizontal plane and in the vertical plane, where it changes from a saddle shape to a more flat structure [5]. Preserving them can improve the result and durability of the repair [4].…”

Section: Introductionmentioning

confidence: 99%

Nova tecnologia: valvuloplastias com anéis biodegradáveis

Neirotti¹,

Çıkırıkçıoğlu

Martina³

et al. 2008

Rev Bras Cir Cardiovasc

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Resultados: Grupo 1 -mortalidade hospitalar: 3,3%; seguimento médio: 26,4 meses + 15,4. Quatro pacientes submetidos à substituição da valva mitral 1,2,2 e 4 meses pós-reparo. Grupo 2 -mortalidade hospitalar: 1,2%; seguimento médio: 26,7 meses, + 13,4. Sete reoperações mitrais entre 1 a 24 meses, duas para novo reparo da válvula, cinco para substituição valvar. Conclusões: Anéis biodegradáveis remodelam a forma, reforçam o reparo, devolvem a função das valvasThis study was carried out at

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Novel Approaches to Cardiac Valve Repair

Cited by 110 publications

References 56 publications

Relationship Between Race and Mortality and Morbidity After Valve Replacement Surgery

Relationship Between Race and Mortality and Morbidity After Valve Replacement Surgery

Cellular and Neuronal Aspects in Aortic Stenosis

Nova tecnologia: valvuloplastias com anéis biodegradáveis

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