Novel Approach with Controlled Nucleation and Growth for Green Synthesis of Size-Controlled Cyclodextrin-Based Metal–Organic Frameworks Based on Short-Chain Starch Nanoparticles

Qiu, Chao; Wang, Jinpeng; Zhang, Huang; Qin, Yang; Xu, Xueming; Jin, Zhengyu

doi:10.1021/acs.jafc.8b03144

Cited by 66 publications

(24 citation statements)

References 40 publications

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“…This study verified that A and B could be new types of multifunctional drug carriers and also offered the possibility of synergistic drug delivery based on CD-MOFs. Recently, Jin et al designed and synthesized nano- and micro-sized γ-CD-MOFs based on a novel approach with controlled nucleation and growth, which could conveniently and quickly obtain uniform CD-MOFs and keep their structural integrity [96]. Through loading experiments with resveratrol, CD-MOFs exhibited a relatively high loading capacity and a consequently sustained release, indicating that they could be used as delivery carriers for drugs and controlled-release systems.…”

Section: Drug Deliverymentioning

confidence: 99%

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

et al. 2018

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Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed.

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Section: Drug Deliverymentioning

confidence: 99%

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

et al. 2018

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“…CD-MOF is the supramolecular assembly, where γ -CDs are used as building blocks and potassium ions play an auxiliary role in the coordination of ( γ -CD) 6 cubic cell units and link them to form a whole three-dimensional topological network crystal 30 , 31 , 32 . Recently, a number of reports on CD-MOF as a promising drug carrier have emerged to load valsartan 33 , folic acid 34 , sucralose 35 , leflunomide 36 , resveratrol 37 , ibuprofen 38 and lansoprazole 39 . However, most of these studies have focused on enhancing the solubility, stability and bioavailability of drugs 40 , 41 .…”

Section: Introductionmentioning

confidence: 99%

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Zhao

Guo

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ -cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

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Section: Figurementioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

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Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.

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Novel Approach with Controlled Nucleation and Growth for Green Synthesis of Size-Controlled Cyclodextrin-Based Metal–Organic Frameworks Based on Short-Chain Starch Nanoparticles

Cited by 66 publications

References 40 publications

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

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