Novel approach to long sustained multilayer nanocapsules: influence of surfactant head groups and polyelectrolyte layer number on the release of hydrophobic compounds

Microfluidic platform for photodynamic therapy cytotoxicity analysis of nanoencapsulated indocyanine-type photosensitizers

“…The surface charge was determined by f-potential measurements and as it has been proved in our previous studies, the stable nanostructures were obtained when the zeta potential of nanocarriers with the adsorbed PE layer was close to the zeta potential of the same polycation or polyanion in solution. 34,35 Consequently, the volumes of polyelectrolyte solution used to form each layer of nanocapsules shell were determined experimentally by the evaluation of the results of simultaneous zeta potential measurements. The results of f-potential measurements during the LbL deposition are typical zigzag dependence used as evidence for the formation of consecutive layers and stability of the obtained nanocapsules.…”

“…34 Commonly, in the case of the loaded nanocapsules, the hydrophobic photosensitizer IR-780 was, in the first step, dissolved in oleic acid (0.2 mg/ml) prior to emulsification with C 12 (TAPAMS) 2 . Next, the oil-core nanoemulsion templates were covered via the LbL adsorption of oppositely charged polyelectrolytes: anionic PSS and cationic PDADMAC to form multilayer shell nanocapsules.…”

“…It also allows improving drug's efficacy, its stability, and better intracellular penetration, owing to their enhanced permeation, specific cell targeting, and long circulation in blood stream. [31][32][33][34][35] We have selected a NIR heptamethine indocyanine dye (i.e., IR-780 iodide) as a model hydrophobic photosensitizer basing mainly upon its excellent optical properties and good photosensitizing attributes. IR-780 indocyanine due to its characteristic excitation (k exc.…”

Nanoparticle-functionalized microcapsules for in vitro delivery and sensing

“…Cells which have incorporated capsules are also protected from direct contact with the containing cargo. (iii) Size and charge of the PEM capsules can be easily tuned [14,20] . Size and charge are important parameters which affect interaction with cells.…”

Synthesis, surface activity and antielectrostatic properties of new soft dichain cationic surfactants

“…The most commercially viable example of soft surfactants comprises the family of cationic ester-containing representatives (abbreviated often as esterquats) with the ester bond inserted between the hydrocarbon tail and the quaternary ammonium head group [10,11]. In the late 90's of the 20 th century a new group of quaternary ammonium salts appeared, these are the so called diesterquats (comprising most often ester or amide moieties inserted in both tails) that successfully supplant classical dialkyl quats, surfactants of a limited biodegradability, and which synthesis is a multistage process [10].In recent years, the scientific and applied interest in cationic surfactants has increased (besides those including the washing and emulsification processes), partly because of the urge for cationic amphiphiles to be used in forthcoming applications, such as new nanocarrier systems, including DNA compaction, engineered nanostructures or functional interfaces [12][13]. Studies on interfacial properties of cationic surfactants are very important for many practical applications related to their solubilization ability, adsorption and aggregation properties, improvement of wetting and antimicrobial activity against bacteria, yeasts and molds [2,7,9,[11][12][13][14].…”