Novel approach in synthesizing ternary GO‐Fe₃O₄‐PPy nanocomposites for high Photothermal performance

Abstract

In this study, graphene oxide‐iron oxide‐polypyrrole (GO‐Fe3O4‐PPy) ternary nanocomposites having high photothermal activity and stability are synthesized and analyzed using ultraviolet–visible (UV–Vis) spectroscopy, Fourier transform infrared (FTIR), X‐ray diffraction spectroscopy (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high‐resolution transmission electron microscopy (HRTEM), and magnetic hysteresis measurement (VSM). The effect of power density (1.5–2.5 W cm−2), concentration (0.01–0.2 mg mL−1), and component composition of nanocomposites on the photothermal properties in the near‐infrared (NIR) region (808 nm) is examined. The results show that superparamagnetic GO‐Fe3O4‐PPy ternary nanocomposite exhibits excellent photothermal performance. The temperature reaches to 55.5, 72.3, and 83.1 °C under the irradiation of the 808 nm NIR laser at 1.5, 2.0—, and 2.5 W cm−2 of power density for 10 min at 0.1 mg mL−1 photothermal therapy (PTT) agent, respectively, and moreover it has excellent photothermal stability. In summary, it is concluded that synthesized nanocomposites potentially may be used in simultaneous magnetic field‐guided treatments. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48837.

Evolution of graphene oxide (GO)-based nanohybrid materials with diverse compositions: an overview

“…First, the GO nanosheets were fabricated through the modified Hummers' method, and then, the Fe 3 O 4 nanoparticles and polypyrrole were decorated on the surface of the GO nanosheets by co-precipitation of ferrous salts and pyrrole monomer in the GO suspension. 258 In the successive year a nanocomposite with a similar composition was reported by Getiren et al 259 who have explored the photothermal property of the same, having application in photothermal therapy (PTT). The temperature of the PTT agents was found to reach 55.5 °C, 72.3 °C and 83.1 °C under the irradiation with an 808 nm NIR laser for 10 min under specified conditions.…”

TLR-7/8 Agonist-Loaded Polypyrrole-Based Theranostic Nanovaccine for Second Near-Infrared Photothermal Immunotherapy of Cancer

“…The average diameter of PPy NPs measured by TEM was <6 nm (Figure 1a inset), and NC exhibited a nearly uniform size and spherical shape (Figure S2). The optical absorption spectra of NC at different doses (20,40,60,80, and 100 μg/mL) indicated a broad and potent absorption band ranging from visible to NIR, covering both NIR-I and NIR-II biowindows with no obvious sharp peaks (Figure 1b). The well-defined characteristic peaks with 2θ values between 20 and 30 in the XRD pattern demonstrated the amorphous nature of NC and the intermolecular stacking structure, as a large peak occurred at 2θ = 20°(Figure 1c).…”

“…PPy NPs are utilized for a broad range of medical applications, including drug delivery, tissue engineering, and biosensing. 20 PPy NPs with great NIR absorbance are good photothermal organic materials because of their high photothermal conversion efficiency (PCE), long-term photothermal stability, minimal cytotoxicity, and biocompatibility. However, minimal dosages of PPy NPs (<200 μg/mL) induced negligible long-term cytotoxicity in animals.…”

A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion

“…Organic p-conjugated polymers, such as polyaniline (PANI), [27][28][29] polypyrrole (PPy), 30,31 polythiophene, 32 and their derivatives, as a novel generation of promising photothermal agents have attracted tremendous attention, and possess a strong absorption coefficient in the NIR window, high photothermal conversion efficiency, and superior photostability. Among them, polyaniline (PANI) is the first reported polymerbased photothermal agent for anticancer therapy.…”