Novel antibacterial fibers of amphiphilic N‐halamine polymer prepared by electrospinning

Abstract

As a significant role in subcategory of halogen antibacterial field, amphiphilic N‐halamine polymers show a promise as potential antimicrobials having a broad spectrum of microorganisms, long‐term stability, and renewal of their antibacterial properties. By controlling the process parameters, electrospinning has been well recognized as a versatile and effective method being capable of making fibers and could be easily engineered with desired pore size and porosity to enhance the antimicrobial properties. The amphiphilic N‐halamine P (ADMH‐MMA‐HEMA) terpolymer fibers showed efficient antimicrobial properties against both Gram‐positive and Gram‐negative bacteria within brief contact time. The result meant that the polymer fibers of macromolecular architecture with control of structural parameters such as hydrophobicity/hydrophilicity balance achievement improved antimicrobial activities via electrospinning technique. In vitro cytotoxicity study demonstrated that the polymer was biocompatible. As a result, the integration of amphiphilic antibacterial materials and the electrospinning technique provided us a feasible method to fabricate biocompatible antimicrobial products easily with low manufacturing cost and would be applied in many promising application areas.

Antibacterial N-halamine fibrous materials

“…One is blending N -halamine compounds which serve as antibacterial additives with other spinnable polymers, such as PAN [ 49 , 118 ], cellulose acetate [ [119] , [120] , [121] ], nylon-6 [ 122 ], polyurethane [ 48 ], or PMMA [ 52 ]. The other is employing the spinnable polymeric N -halamine to fabricate electrospun fibrous materials directly [ [123] , [124] , [125] , [126] , [127] ]. In the first case, Bai et al [ 52 ] firstly selected two N -halamine compounds, 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) and 1,3-dibromo-5,5-dimethylhydantoin (DBDMH), as the model N -halamines.…”

Durable polymericN-halamine functionalized stainless steel surface for improved antibacterial and anti-biofilm activity

“…Nhalamine based polymer has been mainly used in application such as in water disinfection, in antimicrobial paints and in antimicrobial treatment of textiles etc. [15][16][17][18][19][20][21][22][23][24][25][26][27][28]. There are few reports which describe the application of N-halamine in the development of antimicrobial surface for SSL [29][30][31][32].…”

Cost-Effective Fabrication, Antibacterial Application and Cell Viability Studies of Modified Nonwoven Cotton Fabric

“…Different kinds of N-halamine compounds have been extensively investigated for antimicrobial activities.. (Zhu, Chang et al 2019) Inspired by earlier ndings, this paper aims to investigate nonwoven cotton fabric coated with N-halamine and silver nanoparticles to enhance synergistically their effectiveness against microbial growth. N-halamine, chitosan, and silver nanoparticles modi ed nonwoven cotton fabric (hereafter termed and read as N-halamine-chitosan@AgNPs (NWCF)) are fabricated by the chlorination of chitosan coating.…”