Novel angiotensin I-converting enzyme inhibitory peptide derived from bovine casein

Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk

“…These peptides displayed high ACE inhibitory activity which compares favorably with the activity of captopril, an ACE inhibitor, on weight basis. Previously reported MKP peptide from bovine αs2-casein showed IC50 values of 0.12 μg/mL, 0.3 μM [18] and IVY peptide from wheat germ exhibited IC50 values of 0.48 μM [19]. However, most reported food-derived peptides exhibited IC50 values ranging from 32.9 to 128 μM [14], [20], [21], which are much higher than the values of goat peptides found in this study.…”

Peptides: Production, bioactivity, functionality, and applications

“…Additionally, several enzymes can be utilized in the production of only one protein hydrolysate. Although they may be added simultaneously (Yamada et al, 2013;Garc ıa-Moreno et al, 2017), sequential addition (e.g., after progressive decrease in the reaction rate) is normally carried out in order to achieve hydrolysates with a higher DH (Va stag et al, 2011;Garc ıa-Moreno et al, 2014.…”

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides

“…For example, enzymatic food protein hydrolysates and peptides with antihypertensive activities have been widely demonstrated García-Tejedor et al, 2014;He, Alashi, Malomo, et al, 2013;He, Malomo, Alashi, et al, 2013;He, Malomo, Girgih, Ju, & Aluko, 2013;Huang, Sun, He, Dong, & Li, 2011;Li et al, 2011;Majumder et al, 2013;Yamada et al, 2013). Some of the reports have also shown that the blood pressure-lowering effect of the food protein hydrolysates and peptides is related to direct in vivo reduction in plasma ACE and renin activities (García-Tejedor et al, 2014;Girgih, Alashi, He, Malomo, & Aluko, 2014;Huang et al, 2011).…”