Novel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs

Almeida, Andreia; Araújo, Marco; Novoa-Carballal, Ramón; Andrade, Fernanda; Gonçalves, Hugo; Reis, Rui L.; Lúcio, Marlene; Schwartz, Simó; Sarmento, Bruno

doi:10.1016/j.msec.2020.110920

Cited by 74 publications

(40 citation statements)

References 72 publications

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“…At intestinal pH levels, CS contained less charged, and the chains had more mobility. 36 Hence, FITC-labeled CS remained intact in the pH environment below 7.0, but became unstable and disintegrated at pH above 7.0. 37 Altogether, FITC-labeled CS showed different cumulative release rates in both articial gastric juice and articial intestinal uid.…”

Section: In Vitro Release Experiments Of Fitc-labeled Csmentioning

confidence: 95%

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

Han

Zhao

et al. 2020

RSC Adv.

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Section: In Vitro Release Experiments Of Fitc-labeled Csmentioning

confidence: 95%

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

Han

Zhao

et al. 2020

RSC Adv.

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“…In many of these modification studies, amphiphilic CS has been an important class of CS derivative. Hydrophobic and hydrophilic groups are introduced into the molecular structure of CS, and nanoscale micelles can be obtained through molecular self-assembly [ 45 , 46 , 47 , 48 , 49 ]. These types of nanoscale micelles can embed fat-soluble active substances, which improves the application range of drugs with poor solubility in water.…”

Section: Introductionmentioning

confidence: 99%

Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Quan

Kong

et al. 2021

Molecules

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Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.

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“…Chitosan resemblance to mammalian polysaccharides and ability to form hydrogels combined with other characteristics, make it a very promising biomaterial in many applications [ 7 , 8 , 9 , 10 ]. Some recent studies include preparation of composite scaffolds based on chitosan functionalized with boronic acid [ 11 ], bone biomicroconcretes containing hybrid hydroxyapatite-chitosan granules [ 12 ], chitosan encapsulation of bioactive molecules [ 13 ], amphiphilic micelles for cancer therapy based on CS grafted with O -methyl- O ′-succinylpolyethylene glycol and oleic acid [ 14 ], or even a potential application of N -(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) as inhibitor of some current coronaviruses [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation

Kosowska

Domalik-Pyzik

Sekuła-Stryjewska

et al. 2020

IJMS

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In this study, we investigated preparation of gradient chitosan-matrix hydrogels through a novel freezing–gelling–thawing method. The influence of three types of graphene family materials (GFM), i.e., graphene oxide (GO), reduced graphene oxide (rGO), and poly(ethylene glycol) grafted graphene oxide (GO-PEG), as well as hydroxyapatite (HAp) on the physicochemical and biological properties of the composite hydrogels was examined in view of their potential applicability as tissue engineering scaffolds. The substrates and the hydrogel samples were thoroughly characterized by X-ray photoelectron spectroscopy, X-ray diffractometry, infrared spectroscopy, digital and scanning electron microscopy, rheological and mechanical analysis, in vitro chemical stability and bioactivity assays, as well as initial cytocompatibility evaluation with human umbilical cord Wharton’s jelly mesenchymal stem cells (hUC-MSCs). We followed the green-chemistry approach and avoided toxic cross-linking agents, using instead specific interactions of our polymer matrix with tannic acid, non-toxic physical cross-linker, and graphene derivatives. It was shown that the most promising are the gradient hydrogels modified with GO-PEG and HAp.

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Novel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs

Cited by 74 publications

References 72 publications

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation

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