Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

Abstract

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

“…Additionally, free Pip and Ru had similar negative zeta values of −47.35± −6.58 and −46.36± −1.28, respectively. For ZrMOF, the surface modification altered the zeta potential from −37.1 (ZrMOF) to −43.21 (ZrMOFTS), in good agreement with previous results for MOFs (Hidalgo et al, 2017 ; Li et al, 2020 ). These findings may indicate that all of these materials are electrically stable when suspended in water.…”

“…As shown in Figure 4 , several peaks could be seen between 400 and 1750 cm −1 , confirming the similar surface compositions for ZrMO and TiMO (Vilela et al, 2017 ; Sarker & Jhung, 2019 ; Li et al, 2020 ). Moreover, spectra obtained for pure prodrugs Pip and Ru presents main IR bands in the same spectral range 400–1750 cm −1 .…”

“…The reaction was carried out at 100 °C for 24 h. MOFs were separated from the reaction solution by centrifugation (10,000 rpm, 5 min × 3) and washing with methanol. Finally, the drying process was carried out under vacuum at 55 °C, and UiO-66 was obtained (Abdelhameed et al, 2018 ; Li et al, 2020 ).…”

Enhanced Oral NO Delivery through Bioinorganic Engineering of Acid-Sensitive Prodrug into a Transformer-like DNIC@MOF Microrod

“…Metal–organic framework (MOF), a porous coordination polymer consisting of metal nodes and organic linkers, receives wide interests in biomedical applications to imaging, biocatalysis, and drug delivery due to its high surface area, modulated porosities, flexible/versatile chemical composition/reactivity, and biodegradability under certain conditions. − To utilize MOF as an oral drug delivery system (or an orally active drug), , high-valence metal center (Fe 3+ , Y 3+ , Zr 4+ , Ti 4+ ) and exquisite design of organic linker (benzenecarboxylic acids and their derivatives) are critical to improve its stability under acidic environment, − to enhance its biocompatibility, , and to facilitate the loading of drug/cargo through noncovalent interactions (Table S1). − For example, confinement of insulin (or aspirin) in acid-resistant NU-1000 (or MIL-100­(Fe)) facilitates the exceptional stability of Insulin@NU-1000 (or ASA@MIL-100­(Fe)) under simulated gastric condition (pH 1.2), whereas phosphate-triggered degradation of NU-1000 under simulated physiological condition (pH 7.0) triggers the release of encapsulated insulin. , On the other hand, incorporation of a nitrogen heterocycle in the aromatic di-/tricarboxylate linkers into Zr 4+ -/Y 3+ -based MOFs enables the pH-responsive loading/release of drugs (i.e., ibuprofen, diclofenac) through the formation/cleavage of hydrogen-bonding interaction with the protonated/nonprotonated linker under acidic/neutral environment. − In addition to acid-resistant MOFs, encapsulation of Drug@MOF conjugates in pH-responsive polymers (i.e., carboxymethylcellulose, gelatin, chitosan, mPEG- b -PLLA, montmorillonite) was also reported to enhance gastrointestinal drug delivery and therapeutic efficacy (Table S1). − In particular, encapsulation of insulin-loaded and sodium dodecyl sulfate (SDS)-capped MIL-100 nanoparticles within a biodegradable microsphere led to the asse...…”

Two Fascinating Polysaccharides: Chitosan and Starch. Some Prominent Characterizations for Applying as Eco-Friendly Food Packaging and Pollutant Remover in Aqueous Medium. Progress in Recent Years: A Review

“…The antimicrobial capacity of CS, along with being biocompatible and non-toxic, provides unique features to this biopolymer which has been studied in depth with the goal of being applied in various fields such as pharmaceutical [ 72 ], medicine [ 41 ], food industry [ 73 ], etc. This review approaches some characterizations that describe and support classic methods concerning the use of chitosan in the food packaging industry and starch as pollutants remover.…”