Novel amoxicillin nanoparticles formulated as sustained release delivery system for poultry use

Abstract

Amoxicillin is used in the treatment and prevention of a wide range of diseases in poultry breeding. However, its short half-life and low bioavailability restrict its clinical application in these species. Entrapment of drugs into polymeric nanoparticles (nps) presents a means to improve gastrointestinal absorption and oral bioavailability of drugs. This study was aimed to overcome limitation of amoxicillin use in poultry breeding. Amoxicillin was loaded into sodium alginate-polyvinyl alcohol (NaAlg-PVA) blend nps, and characterization of the prepared nps was performed. For pharmacokinetic study, commercial male broilers were used and comparative pharmacokinetics of free and nanoparticle form of amoxicillin were investigated. Twenty-one broilers were divided into three groups. All groups received 10 mg/kg drug. Blood samples were collected, and drug plasma concentrations were determined by HPLC. The results demonstrated that the particle size, zeta potential, encapsulation efficiency, and loading capacity of the nps were 513.96 ± 19.46 nm, -45.36 ± 1.35 mV, 43.66 ± 3.30, and 12.06 ± 0.83%, respectively. In vitro drug release exhibited a biphasic pattern with an initial burst release of 18% within 2 hr followed by a sustained release over 22 hr. The pharmacokinetic results showed that amoxicillin nps have higher bioavailability and longer plasma half-life (p < .01) than free amoxicillin. These results indicate that amoxicillin nano formulation is suitable for oral administration in broilers.

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

“…As expected, the release rate of amoxicillin increases with the amoxicillin loading increasing in the cellulose aerogel. There is an initial rapid burst release for all tested aerogels in the first 2 h, which is thought to be associated with the drug that is absorbed or weakly bounded to the surface of cellulose aerogel [ 31 ]. Then, a gradually increased release rate of amoxicillin was shown.…”

Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties

“…Ganta et al intravenously injected asulacrine NCs and also perceived a 2.7-fold lifespan enhancement in the plasma compared to the asulacrine solution 62 . Besides the solid form of NCs increasing the plasma lifetime 63 , the www.nature.com/scientificreports/ use of stabilizer comprising PEG is known to reduce protein binding and therefore extend the particle's plasma concentration 64,65 . Interestingly, the AUC 0-120 min for free etoposide is close to that of Toposar and NCs with the different stabilizer layers present close AUC 0-120 min (cf.…”

A Study into the Electrochemical Behavior of Nano Antibiotics as A Promising Treatment for Helicobacter Pylori Infection by Cyclic Voltammetry

“…While in acidic pH, the Nano-kit acts as an oxidant stress because the oxidant peak appears in the cyclic voltammetry. The use of nanoantibodies in other work or local work has been observed in various medical fields without their use in electrochemical studies [16,[18][19][20].…”