Novel aminohydrazide cross-linked chitosan filled with multi-walled carbon nanotubes as antimicrobial agents

Mohamed, Nadia A.; El‐Ghany, Nahed A. Abd

doi:10.1016/j.ijbiomac.2018.04.101

Cited by 45 publications

(34 citation statements)

References 32 publications

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“…It was demonstrated that the incorporation of aminohydrazide groups is very effective in improving the antifungal activity of chitosan. In particular, the derivative 4/MWCNT1 displayed antifungal activity against C. neoformans that was close to that of the positive control drug amphotericin B (Mohamed & Abd El-Ghany, 2018). In 2015, Tiera's group reported synthesis of amphiphilic chitosan derivatives with diethylaminoethyl(DEAE) ( Fig.…”

Section: Introducing Polyamino Groupsmentioning

confidence: 84%

“…Hence, before discussing and summarizing the antifungal activity and structure-activity relationship of cationic chitosan derivatives, it should be pointed out that the following modification strategies for improving the cationic properties of chitosan are also common methods to improve the antibacterial activity of chitosan. Some studies have also proven that chitosan derivatives containing cationic groups usually possess both antifungal and bacteriostatic activities (Hassan, 2018;Mohamed & Abd El-Ghany, 2018;Yang, Cai, Hu, Li, & Du, 2012).…”

Section: Strategies For Increasing Positive Charge Density Of Chitosanmentioning

confidence: 99%

“…Generally, cationic chitosan derivatives not only has good water solubility and antifungal activity, but also maintains the advantages of good biocompatibility and biodegradability of chitosan. Moreover, it can also be processed by copolymerization, crosslinking, blending, forming complex with metal ions, and so on, so as to obtain materials, such as membranes, gels, coating, scaffolds, for different uses (Hassan, 2018;Mohamed & Abd El-Ghany, 2018;Mohamed, Elella, & Sabaa, 2015;Pranantyo et al, 2018;Tabriz et al, 2019). Among the diverse applications of cationic chitosan derivatives to inhibit fungi, one of the most noticeable may be its disinfection control in clinics, hospitals and some medical environments.…”

Section: Tablementioning

confidence: 99%

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Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

Qin

Guo

2020

Carbohydrate Polymers

123

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The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.

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Section: Introducing Polyamino Groupsmentioning

confidence: 84%

Section: Strategies For Increasing Positive Charge Density Of Chitosanmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

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Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

Qin

Guo

2020

Carbohydrate Polymers

123

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“…The produced material (2 g) was stirred in solution of ethanolic HCl (0.24 mol/L HCl) at 25 °C overnight, filtered, rinsed with ethanol and dried to obtain CLCS ( Figure 1 ). This preparation method was described in detail in our recently published work [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Cross-Linked Chitosan/Multi-Walled Carbon Nanotubes Composite as Ecofriendly Biocatalyst for Synthesis of Some Novel Benzil Bis-Thiazoles

et al. 2021

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Aminohydrazide cross-linked chitosan (CLCS) and its MWCNTs (CLCS/MWCNTs) were formulated and utilized as a potent ecofriendly basic heterogeneous biocatalyst under ultrasonic irradiation for synthesis of two novel series of benzil bis-aryldiazenylthiazoles and benzil bis-arylhydrazonothiazolones from the reaction of benzil bis-thiosemicarbazone with 2-oxo-N′-arylpropanehydrazonoyl chlorides and ethyl 2-chloro-2-(2-phenylhydrazono) acetates, respectively. The chemical structures of the newly synthesized derivatives were elucidated by spectral data and alternative methods, where available. Additionally, their yield % was estimated using a traditional catalyst as TEA and green recyclable catalysts as CLCS and CLCS/MWCNTs composite in a comparative study. We observed that, under the same reaction conditions, the yield % of the desired products increased by changing TEA to CLCS then to CLCS/MWCNT from 72–78% to 79–83% to 84–87%, respectively. The thermal stability of the investigated samples could be arranged as CLCS/MWCNTs composite > CLCS > chitosan, where the weight losses of chitosan, CLCS and CLCS/MWCNTs composite at 500 °C were 65.46%, 57.95% and 53.29%, respectively.

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“…The chitosan has important biotechnological and industrial applications, such as wastewater purification, chelation of transition metals, immobilization of whole cells, and coating seeds for enhancing yield [10,[12][13][14][15]. In addition, chitosan and its derivatives have been shown to have antimicrobial activities [16][17][18]. Water-soluble chitosan, which have modified pendent antimicrobial active groups can be envisaged to have better antimicrobial properties with lower toxicity.…”

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confidence: 99%

Antimicrobial Activity of Amino-Derivatized Cationic Polysaccharides

et al. 2018

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To improve the antimicrobial property of chitosan, water-soluble chitosan modified in their quaternary ammonium groups were synthesized. The antimicrobial properties were evaluated against Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae and Candida tropicalis. The activities increased with increasing cationic charges and the length of the alkyl chain as follows aminochitosan, dimethylaminoethyl-chitosan, dimethylpropyl amino-chitosan, dimethylamino-1-propyl-chitosan, diethylaminoethyl (DEAE)-chitosan, and quaternized DEAEchitosan. The modified cationic chitosans showed high antimicrobial property against B. subtilis-Gram-positive bacteria, but were less active towards yeast (C. tropicalis and S. cerevisiae) and E. coli-Gram-negative bacteria. The simple structure of the Gram-positive bacteria may explain why the cationic chitosan derivatives are more active towards B. subtilis than yeast and E. coli. The target sites of the chitosan derivatives are assumed to be the cytoplasmic membranes of microorganisms. The antimicrobial activities were strongly dependent on the cationic charge and the molecular weight. It can be suggested that these cationic chitosan derivatives have potential as antimicrobial agents. Keywords Antimicrobial activity Á Bacillus subtilis Á Cationic chitosan derivatives Á Gram-negative bacteria Á Gram-positive bacteria Electronic supplementary material The online version of this article (

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Novel aminohydrazide cross-linked chitosan filled with multi-walled carbon nanotubes as antimicrobial agents

Cited by 45 publications

References 32 publications

Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

Cross-Linked Chitosan/Multi-Walled Carbon Nanotubes Composite as Ecofriendly Biocatalyst for Synthesis of Some Novel Benzil Bis-Thiazoles

Antimicrobial Activity of Amino-Derivatized Cationic Polysaccharides

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